Director, Global Supply Chain - Operational Excellence (LEAN)
$223.2k - $260.4kCytokinetics
- # Director, Global Supply Chain – Operational Excellence (LEAN)Applylocations: South San Francisco, Californiatime type: Full timeposted on: Posted Yesterdayjob requisition id: R473Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.The Director of Operational Excellence (OpEx) is a key leadership role responsible for driving end-to-end process improvement, operational efficiency, and organizational capability building across Supply Chain, External Manufacturing, and Technical Operations within the pharmaceutical manufacturing network. This role will partner with internal and external stakeholders to deliver transformational initiatives, ensure robust supply performance, and enhance the company’s ability to deliver high-quality medicines to patients reliably and cost-effectively.The ideal candidate brings expertise in Lean Six Sigma, pharmaceutical manufacturing processes (including cGMP), and the unique challenges of managing a global external manufacturing and supply network.# **Responsibilities:**Lead Operational Excellence Strategy & Execution* Develop and execute the Operational Excellence roadmap for Supply Chain, External Manufacturing, and Technical Operations, aligned with business goals and priorities.* Drive transformational initiatives that enhance reliability, agility, and cost-effectiveness of the end-to-end supply network.* Embed a culture of continuous improvement across internal teams and external partners.* Monitor industry trends and benchmark performance to sustain competitive advantage in operational practices.Process Improvement & Performance Optimization* Identify, prioritize, and implement process improvement opportunities to enhance service, reduce costs, and ensure compliance across planning, sourcing, manufacturing, and distribution.* Facilitate cross-functional projects using Lean, Six Sigma, Value Stream Mapping, and other proven methodologies.* Support Technical Operations in problem-solving initiatives by coaching team leads to effectively utilize fit-for-purpose frameworks for identifying root cause(s).* Standardize and digitize key supply chain and manufacturing processes to improve visibility, control, and decision-making.External Manufacturing & Supplier Excellence* Collaborate with CMOs/CDMOs and internal stakeholders to assess and improve external manufacturing performance through systematic KPI reviews and improvement plans.* Lead joint improvement initiatives with external partners while ensuring cGMP and regulatory compliance.* Build strong relationships and foster a culture of collaboration and continuous improvement with suppliers and contract manufacturers.Tier Management & Visual Performance Management* Design, implement, and sustain a Tiered Management System (Tier 1–3) across Supply Chain, External Manufacturing, and Technical Operations to enable effective daily, weekly, and monthly performance management.* Deploy visual management tools and performance dashboards at each tier level to drive accountability, transparency, and fast problem resolution.* Train and coach teams and partners in daily management practices, visual controls, and structured problem-solving.* Ensure escalation processes and feedback loops are effective and standardized across the network.Capability Building & Change Leadership* Build organizational capabilities by developing and delivering training on Operational Excellence tools and methodologies to internal teams and external partners.* Coach functional and site leaders in OpEx mindset and practices to enable self-sufficiency and sustained improvements.* Lead change management efforts to overcome resistance and embed new ways of working.* Act as a role model for continuous improvement, demonstrating a data-driven, collaborative, and solution-oriented approach.# **Qualifications & Experience:*** Bachelor’s degree in Engineering, Supply Chain Management, Life Sciences, or related field required; Master’s degree or MBA preferred.* Minimum 8–10 years of experience in a regulated healthcare industry segment (e.g., pharmaceutical development, supply chain, manufacturing, medical device, or technical operations, with at least 5–10 years in operational excellence, continuous improvement, or similar leadership roles.* Strong understanding of manufacturing and supply chain processes, cGMP, regulatory requirements, and the complexities of external manufacturing.* Certified Lean Six Sigma Black Belt (or equivalent) strongly preferred.* Proven track record of delivering measurable improvements in operational performance, cost reduction, and process efficiency.* Experience managing and improving external manufacturing or supplier relationships in a regulated industry.* Exceptional project management, change management, and facilitation skills.* Excellent communication, influencing, and stakeholder management abilities across all organizational levels and with external partners.* Ability to thrive in a fast-paced, matrixed, and global environment.**Competencies*** Strategic thinking with a hands-on approach.* Results-oriented and data-driven decision-making.* Strong analytical and problem-solving skills.* Ability to lead without authority and drive collaboration.* Passion for excellence and continuous improvement. #LI-HYBRID**Pay Range:**In the U.S., the hiring pay range for fully qualified candidates is $223,200 - $260,400 per year. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.*Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.***Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.**Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.**Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers**Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process.Here are some ways to check for authenticity:* We do not conduct job interviews through non-standard text messaging applications* We will never request personal information such as banking details until after an official offer has been accepted and verified* We will never request that you purchase equipment or other items when interviewing or hiring* If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at View email address on click.appcast.io**Please visit our website at: is an Equal Opportunity Employer**
- J-18808-Ljbffr Cytokinetics
Vacancy posted 1 day ago
Similar jobs that could be interesting for youBased on the Director, Global Supply Chain - Operational Excellence (LEAN) in South San Francisco, CA vacancy
- Cytokinetics in South San Francisco is seeking a Director of Global Supply Chain - Operational Excellence to spearhead process improvements and operational efficiency... ...in the regulated healthcare sector, strong Lean Six Sigma expertise, and a proactive approach to operational...Suggested
$225k - $250k
...security. Our team is led by veteran operators and engineers, alumni of Sonos, Paypal... ...The Role We're hiring a Head of Supply Chain & Global Operations to own and build our... ...chain performance Drive operational excellence across vendors and internal teams...SuggestedContract workLocal areaSauron
San Francisco, CA1 day ago$140k - $170k
...developers, we are improving the global financial system and creating... ...of Global Procurement Operations to join our Financial Operations... ...will report directly to the Director of Financial Operations, based... ...cost management and operational excellence. Accelerate organizational...SuggestedWork at officeLocal area$184k - $262k
...software product development, operational excellence, and customer obsession to... ...from the trenches to ensure supply continuity but also do so cost... ...the company's Supply Chain and Sourcing processes and tools... ...forecasting, production and broader global supply chain issues for...SuggestedFull timeTemporary workLocal areaRelocation packageSkydio
San Mateo, CA1 day ago$243.1k - $314.6k
...role in Foster City, CA at our global headquarters.... ...Enterprise Category Strategy Excellence Strategy Framework Design and... ...: Category Leads, Executive Directors and Senior Directors Sourcing... ...engagement models. · Sourcing Operations Strategy & Pipeline Orchestration...SuggestedFull timeFor contractorsWork experience placementLocal areaWorldwide$145k - $150k
...and equitable future. Position: Director, Business Operations and Supply Chain (Retail) (Full-time w/ benefits)... ...millions of visitors both locally and globally to the GGNRA annually.... ...with Microsoft Office, particularly Excel; working knowledge of POS systems,...Full timeWork at officeLocal areaRemote workRelocationShift work2 days per week$123.6k - $185.4k
...Transformation Program Manager, Operations and AI Stripe is a... ...unprecedented opportunity to put the global economy within everyone's... ...direct experience in procurement, supply chain, finance operations,... ...process improvement methodologies (Lean, Six Sigma, process mapping,...Permanent employmentFull timeWork at officeImmediate startStripe
South San Francisco, CA22 hours ago$150k - $190k
...Peak Energy Job Title: Global Supply Chain Manager - ESS Location: Burlingame, CA... ...We are a team of engineers, operators, entrepreneurs, and partners driven by... ...Engineering, Supply Chain OR demonstrated excellence in global supply chain management, strategic...Full timeContract workFlexible hoursPeak Energy Services
Burlingame, CA5 days ago$121.8k - $251k
...We design, build, and operate the world's largest autonomous... ..., delivering critical supplies quickly and reliably.... ..., restaurants and global businesses who rely on... ...system strengthens supply chains, reduces congestion, and... ...production. You excel at high-stakes commercial...Contract workLocal areaDay shiftZipline
South San Francisco, CA21 days ago$157.59k - $203.94k
...RESPONSIBILITIES: Senior Manager, Global Clinical Supply Chain is a leader that who carries out... ...colleagues (e.g., Regulatory, Clinical Operations, Quality, PDM Product Strategy teams... ...and functional expectations. Excellent verbal, written, and interpersonal communication...Contract workFor contractorsLocal areaWorldwideGilead Sciences
Foster, CA4 days ago$190k - $220k
...CA, SB Energy develops, builds, owns & operates some of the largest and most... ...highly strategic and operationally driven Director, Supply Chain Operations & Governance to build and lead... ...customs processes, HTS classifications, and global trade operations Experience managing...Full timeContract workWork at officeLocal areaRemote workFlexible hoursSB Energy
San Francisco, CA4 days ago- ...Our values guide how we operate. Taking pride in creating new... ...today." Charlie Monk Sr. Director | Capital Markets Phoenix... ...Luke Adams Sr. Director | Supply Chain Belmont, CA "Since... ...Software Archt | Operational Excellence San Mateo, CA "SBE is a...InternshipRemote workNight shift
SB Energy
Belmont, CA4 days ago - ...resourceful and highly motivated Director, Commercial Supply Chain to lead end‑to‑end commercial supply planning and operational launch readiness for... ...impacts on supply, and global distribution logistics. Advanced... .../analytics skills (Excel and/or supply planning tools...Temporary workWork at officeLocal area
- Manager, Supply Chain Operations The Manager, Supply Chain Operations is responsible for establishing... ...with proficiency in tools such as SQL, Excel, or similar, and ability to translate data... ...related to data governance Lean Six Sigma certification or experience applying...Local areaShift work
- ...award-winning products help our global community gain a deeper... ...looking for a Manager to join our Operations FP&A team. This role will... ...FP&A and will partner across Supply Chain and Data functions.... ...stakeholders ~ Strong proficiency in Excel/Google Sheets, experience working...Work at officeLocal areaRemote workFlexible hours3 days per week
URA
San Francisco, CA2 days ago - ...strategic, results-driven Director of Supply Chain to lead and scale its supply chain operations. The ideal... ...and execute a scalable global supply chain strategy... ...Drive operational excellence through metrics (KPIs)... ...continuous improvement (Lean/Six Sigma), and digital...Full timeContract work
Lumicity
San Francisco, CA3 days ago $200k - $300k
...Biomachines is seeking a Head of Manufacturing to lead its global manufacturing and supply chain strategy in South San Francisco. This role demands an... ...and work across R&D and Finance to ensure efficient operations. The role offers $200,000 - $300,000 salary, equity, and...Remote job- A innovative technology company based in California is seeking a Special Projects role focused on leading high-impact Operations initiatives. You will manage cross-functional projects to enhance order fulfillment, logistics, and inventory management. The ideal candidate...
$151k - $184k
...Global Supply Manager, Networking Crusoe is on a mission to accelerate... ...the ground up, we own and operate each layer of the stack —... ...optimize our entire supply chain and procurement operation. This... ...strategic thinking with operational excellence, bringing a strong...Full timeContract workTemporary workCrusoe
San Francisco, CA4 days ago$98k - $122.5k
Global Supply Manager job at Lyft. San Francisco, CA. At Lyft, our purpose is to serve and... ...Manager to join our Global Supply Chain Team. In this role, you will oversee... ...delivering measurable cost savings and operational excellence. Responsibilities Develop and execute...Hourly payContract workWork at officeLocal area3 days per week$110k - $150k
Global Supply Manager Location: United States, Onsite Compensation: 110,000 to 150... ...centre of their aerospace supply chain. They need someone who can operate confidently with suppliers, program... ...individuals with strong judgment, excellent communication skills, and a proactive...$211.14k - $281.52k
...Job Summary The Senior Director, Procurement is... ...to drive cost efficiency, supply chain resilience, operational excellence, and innovation. Through... ...Responsibilities Lead and align global direct and indirect... ...continuous improvement through Lean practices and process...Contract workWork at officeShift workSunrun
San Francisco, CA3 days ago$143k - $229k
...transportation. To get there, we need a supply chain that is as innovative and... .... We are looking for a Global Supply Manager (GSM) -... ...partner to our Engineering and Operations teams, navigating the... ...evolving procurement needs. ~ Excellent stakeholder management and the...Work at officeLocal area3 days per weekAurora Innovation
San Francisco, CA4 days ago$201.3k - $373.8k
...This role is based in Business Strategy & Operations (BSO) which serves as the strategic... ...PDD). The function ensures organizational excellence through robust quality frameworks, optimized... ...when interacting with colleagues in the global workplace You possess excellent...For contractorsLocal areaRelocation packageGenentech
South San Francisco, CA4 days ago$150k - $225k
...Performance Improvement Director, Supply Chain - Distribution & Logistics... ...& Marsal (A&M) is a global consulting firm with over 1... ...engaged A&M to help improve operating results at their portfolio... ...two to four years. We offer excellent opportunities for career advancement...Full timePart timeInterim roleFlexible hoursAlvarez & Marsal
San Francisco, CA4 days ago- ...winning products help our global community gain a deeper... ...We are seeking a Director, Supply Planning to join Oura's Supply Chain organization. This role... ...strong analytical skills, operates at a functional level... ...improvement and analytical excellence. Lead cross-...Contract workTemporary workWork at officeLocal areaRemote workFlexible hours3 days per week
URA
San Francisco, CA2 days ago $160k - $240k
...Senior Operations Manager, Supply - Coding New York City, NY (Hybrid); Redwood City, CA (Hybrid); San Francisco, CA (Hybrid); United States... ...forecasting future workforce needs, and driving operational excellence through data. You will play a critical role in shifting...Local areaImmediate startRemote workShift workSnorkel AI
San Francisco, CA4 days ago- ...Operations Supply Chain Engagement Manager Practice Group: Operations, Energy, Industrials Location... .... Our consulting roles offer excellent career and growth opportunities for talented... ...Wyman? Working as part of our global, entrepreneurial company, you'll do meaningful...Immediate startFlexible hours
Oliver Wyman
San Francisco, CA20 days ago - ...for a Strategic Partnerships Manager to expand its global footprint. This role involves building supply partnerships with hotels and retailers while also establishing... ...strong background in travel or consumer tech, and excellent negotiation skills. Join a dynamic team and help...
$139k - $198k
...hardware and software product development, operational excellence, and customer obsession to empower a... ...programs. Be the liaison between supply chain and engineering for supplier and... ...Identify new high potential suppliers on a global basis. Develop and execute...Full timeContract workWork experience placementLocal areaRelocation package
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Director, Global Supply Chain - Operational Excellence (LEAN). Be the first to apply!
Related searches
- global procurement manager South San Francisco, CA
- purchasing manager South San Francisco, CA
- buying manager South San Francisco, CA
- procurement purchasing manager South San Francisco, CA
- director supply chain planning South San Francisco, CA
- director supply chain management South San Francisco, CA
- director procurement South San Francisco, CA
- director global procurement South San Francisco, CA
- supply chain procurement manager South San Francisco, CA
- supply chain purchasing manager South San Francisco, CA