Director, Global Supply Chain - Operational Excellence (LEAN)
$223.2k - $260.4kCytokinetics
- # Director, Global Supply Chain – Operational Excellence (LEAN)Applylocations: South San Francisco, Californiatime type: Full timeposted on: Posted Yesterdayjob requisition id: R473Cytokinetics is a specialty cardiovascular biopharmaceutical company, building on its over 25 years of pioneering scientific innovations in muscle biology, and advancing a pipeline of potential new medicines for patients suffering from diseases of cardiac muscle dysfunction.The Director of Operational Excellence (OpEx) is a key leadership role responsible for driving end-to-end process improvement, operational efficiency, and organizational capability building across Supply Chain, External Manufacturing, and Technical Operations within the pharmaceutical manufacturing network. This role will partner with internal and external stakeholders to deliver transformational initiatives, ensure robust supply performance, and enhance the company’s ability to deliver high-quality medicines to patients reliably and cost-effectively.The ideal candidate brings expertise in Lean Six Sigma, pharmaceutical manufacturing processes (including cGMP), and the unique challenges of managing a global external manufacturing and supply network.# **Responsibilities:**Lead Operational Excellence Strategy & Execution* Develop and execute the Operational Excellence roadmap for Supply Chain, External Manufacturing, and Technical Operations, aligned with business goals and priorities.* Drive transformational initiatives that enhance reliability, agility, and cost-effectiveness of the end-to-end supply network.* Embed a culture of continuous improvement across internal teams and external partners.* Monitor industry trends and benchmark performance to sustain competitive advantage in operational practices.Process Improvement & Performance Optimization* Identify, prioritize, and implement process improvement opportunities to enhance service, reduce costs, and ensure compliance across planning, sourcing, manufacturing, and distribution.* Facilitate cross-functional projects using Lean, Six Sigma, Value Stream Mapping, and other proven methodologies.* Support Technical Operations in problem-solving initiatives by coaching team leads to effectively utilize fit-for-purpose frameworks for identifying root cause(s).* Standardize and digitize key supply chain and manufacturing processes to improve visibility, control, and decision-making.External Manufacturing & Supplier Excellence* Collaborate with CMOs/CDMOs and internal stakeholders to assess and improve external manufacturing performance through systematic KPI reviews and improvement plans.* Lead joint improvement initiatives with external partners while ensuring cGMP and regulatory compliance.* Build strong relationships and foster a culture of collaboration and continuous improvement with suppliers and contract manufacturers.Tier Management & Visual Performance Management* Design, implement, and sustain a Tiered Management System (Tier 1–3) across Supply Chain, External Manufacturing, and Technical Operations to enable effective daily, weekly, and monthly performance management.* Deploy visual management tools and performance dashboards at each tier level to drive accountability, transparency, and fast problem resolution.* Train and coach teams and partners in daily management practices, visual controls, and structured problem-solving.* Ensure escalation processes and feedback loops are effective and standardized across the network.Capability Building & Change Leadership* Build organizational capabilities by developing and delivering training on Operational Excellence tools and methodologies to internal teams and external partners.* Coach functional and site leaders in OpEx mindset and practices to enable self-sufficiency and sustained improvements.* Lead change management efforts to overcome resistance and embed new ways of working.* Act as a role model for continuous improvement, demonstrating a data-driven, collaborative, and solution-oriented approach.# **Qualifications & Experience:*** Bachelor’s degree in Engineering, Supply Chain Management, Life Sciences, or related field required; Master’s degree or MBA preferred.* Minimum 8–10 years of experience in a regulated healthcare industry segment (e.g., pharmaceutical development, supply chain, manufacturing, medical device, or technical operations, with at least 5–10 years in operational excellence, continuous improvement, or similar leadership roles.* Strong understanding of manufacturing and supply chain processes, cGMP, regulatory requirements, and the complexities of external manufacturing.* Certified Lean Six Sigma Black Belt (or equivalent) strongly preferred.* Proven track record of delivering measurable improvements in operational performance, cost reduction, and process efficiency.* Experience managing and improving external manufacturing or supplier relationships in a regulated industry.* Exceptional project management, change management, and facilitation skills.* Excellent communication, influencing, and stakeholder management abilities across all organizational levels and with external partners.* Ability to thrive in a fast-paced, matrixed, and global environment.**Competencies*** Strategic thinking with a hands-on approach.* Results-oriented and data-driven decision-making.* Strong analytical and problem-solving skills.* Ability to lead without authority and drive collaboration.* Passion for excellence and continuous improvement. #LI-HYBRID**Pay Range:**In the U.S., the hiring pay range for fully qualified candidates is $223,200 - $260,400 per year. The base pay actually offered will take into account internal equity and also may vary depending on the candidate's geographic region, job-related knowledge, skills, and experience among other factors.*Our employees come from different backgrounds, and we celebrate those differences. We are looking for the best candidates for our open roles, but do not expect applicants to meet every qualification in order to be considered. If you are excited about what you could accomplish at Cytokinetics and believe you can add value to our team, we would love to hear from you.***Please review our General Data Protection Regulation (GDPR) policy PRIOR to applying.**Our passion is anchored in robust scientific thinking, grounded in integrity and critical thinking. We keep the patient front and center in all we do – all actions and decisions are in service of the patient and their caregivers. We champion integrity, ethics, doing the right thing, and being our best selves.**Fraud Warning: How to Identify Impersonated Cytokinetics Job Postings and Offers**Recently, there have been fraudulent employment offers being sent to candidates on behalf of Cytokinetics. Please be advised that all legitimate offers from Cytokinetics will come directly from our official email domain (Cytokinetics.com) and will only be made after completing a formal interview process.Here are some ways to check for authenticity:* We do not conduct job interviews through non-standard text messaging applications* We will never request personal information such as banking details until after an official offer has been accepted and verified* We will never request that you purchase equipment or other items when interviewing or hiring* If you are unsure about the authenticity of an offer, or if you receive any suspicious communication, please contact us directly at View email address on click.appcast.io**Please visit our website at: is an Equal Opportunity Employer**
- J-18808-Ljbffr Cytokinetics
Vacancy posted 2 days ago
Similar jobs that could be interesting for youBased on the Director, Global Supply Chain - Operational Excellence (LEAN) in South San Francisco, CA vacancy
$223.2k - $260.4k
...Cytokinetics seeks a Director of Operational Excellence to lead process improvement and operational efficiency across global supply chain, external manufacturing, and technical operations. This... ...role focuses on implementing Lean methodologies, managing external partners...Suggested- Cytokinetics in South San Francisco is seeking a Director of Global Supply Chain - Operational Excellence to spearhead process improvements and operational efficiency... ...in the regulated healthcare sector, strong Lean Six Sigma expertise, and a proactive approach to operational...Suggested
$68k - $177k
...world. About the Team The Supply Chain organization owns the... ...of our products. Global Supply Managers (GSMs)... ...Supply Chain Management, Operations, Business, Finance, or... ...: comfortable in Excel/Google Sheets for cost... ...Certifications & Compliance Lean/Six Sigma...SuggestedFull timeContract workTemporary workFlexible hoursNeuralink
San Francisco, CA2 days ago$100k - $130k
...challenges by building, manufacturing and operating the first instant delivery and... ...people and building a more resilient global supply chain. Join Zipline and help us to make good... ...We need a Global Supply Manager who is excellent at strategizing, sourcing, managing, and...SuggestedContract workWork at officeLocal areaZipLine
South San Francisco, CA3 days ago$121.8k - $251k
...We design, build, and operate the world's largest autonomous... ..., delivering critical supplies quickly and reliably.... ..., restaurants and global businesses who rely on... ...strengthens supply chains, reduces congestion, and... ...roadmap. You bring excellent analytical,...SuggestedLocal areaDay shiftZipline
South San Francisco, CAa month ago$136.34k - $176.44k
...generations to come. As a Global Trade Compliance Manager,... ...managing daily Trade Compliance operations within the US/ Canada as... ...including R & D, Logistics, Supply Chain, Commercial, Tax, Legal, involved... ...and teams, including excellent written and oral communication...Full timeFor contractorsLocal area$248k - $305k
...and financed by top-tier global life sciences investors. The... ..., Global Manufacturing & Supply Chain, the Sr. Director of Commercial Supply Chain... ...will provide strategic and operational leadership for end-to-end... ...supply chain resilience. ~ Excellent leadership, communication,...$203k - $251k
...resourceful, and highly motivated Director, Commercial Supply Chain to lead end‑to‑end commercial supply planning and operational launch readiness for... ...impacts on supply, and global distribution logistics. Advanced... .../analytics skills (Excel and/or supply planning tools...Contract workTemporary workWork at office- Structure Therapeutics, based in California, seeks a Sr. Director of Commercial Supply Chain to lead end-to-end supply chain planning for late‑phase... ...clinical and commercial programs. The role partners with VP, Global Manufacturing & Supply Chain to ensure uninterrupted...
$98k - $122.5k
...Lyft is seeking an experienced Procurement Center of Excellence Manager to join our Global Supply Chain Team. In this role, you will enable Procurement... ...strategies to support business growth and deliver operational excellence. Responsibilities: Partner with Global...Hourly payWork at officeLocal area3 days per weekLyft
San Francisco, CA1 day ago$103.9k - $169.1k
...service. Overview Working as a Global Supply Manager you will be... ...in Business Management, Supply Chain Management or Engineering +5 years... ...fluency in MS Office products Excellent verbal and written communication skills Knowledge of Lean manufacturing practices Desired...Contract workTemporary workPart timeWork experience placementSupportFinity
San Francisco, CA3 days ago$115k - $145k
...building the autonomous supply chain to power fast,... ...’s best engineers and operators. If you are obsessed with... ...Mellon and our board of directors include famed robotics... ...agency. The Role As a Global Supply Chain Manager,... ...execute sourcing strategies Excellent communication and...Contract workLocal areaFlexible hoursNimble Robotics
San Francisco, CA2 days ago$210.38k - $272.25k
...are seeking an experienced Director, Regional Supply Chain to oversee and optimize... ..., and collaborates with global supply chain leadership and... ...closely with Global Trade Operations, Commercial, Finance, and... ...and supply continuity. Excellent communication and stakeholder...Full timeFor contractorsLocal areaGilead Sciences
Foster, CA14 days ago$121.8k - $251k
...anywhere. We design, build, and operate the world's largest... ...system, delivering critical supplies quickly and reliably. Today,... ..., retailers, restaurants and global businesses who rely on us to... ...Our system strengthens supply chains, reduces congestion, and gives...Full timeContract workLocal areaZipline
South San Francisco, CAa month ago$160k - $180k
...Staff Global Supply Manager, Contract Manufacturing About Mytra: We’re creating an... ...1T market. We’re focused on the supply chain industry first. The industry is in a massive... ...planning post-award - defining the operational model, quality gates, and supply chain...Contract workWork at officeMytra Robotics
Brisbane, CA4 days ago$161k - $227.5k
...of developing the company's Supply Chain and Sourcing processes and tools... ...high-potential suppliers globally. Cultivate productive... ...enthusiasm for learning new things. Excellent written and verbal... ...in a United States military operation for which an Armed Forces service...Full timeContract workFor contractorsFor subcontractorWork at officeLocal areaRelocation packageSkydio
San Mateo, CA2 days ago$105.4k - $155k
About the TeamOur New Verticals Strategy & Operations team is re-inventing the way consumers... ...organization, focused on reducing supply chain costs to fuel profitability. In this role... ...proficient at defining net new processes. You excel at working with a diverse group of...Hourly payTemporary workWork at officeLocal areaRemote workFlexible hoursDoordash
San Francisco, CA4 days ago- ...transported, and deployed within high‑demands operational environments. This is a unique... ...collaborative and fast‑paced team where supply chain strategy directly impacts operational scalability... ...planning. Position Summary The Senior Global Supply Manager will lead the sourcing...Shift work
- ...startup who are looking for their first global supply chain manager. If you've built the supply... ...with engineering, manufacturing, and operations to make sure we have the right parts,... ...pricing, lead times, and commercial terms Excellent analytical and problem-solving skills...Contract work
$150k - $225k
...Director, Supply Chain - Distribution & Logistics Open to all U.S. locations... ...Alvarez & Marsal (A&M) is a global consulting firm with over 1... ...engaged A&M to help improve operating results at their portfolio... ...two to four years. We offer excellent opportunities for career...Full timePart timeInterim roleFlexible hoursAlvarez & Marsal
San Francisco, CA13 hours ago$150k - $190k
...and aligned with our operational and financial goals. The... ...and agriculture value chain. We are seeking a... ...purchases, lab/greenhouses supplies & consumables, service... ...outcomes. ~ Excellent communication and interpersonal... ...radically transform global agriculture. For more...Full timeContract workVisa sponsorshipOhalo
South San Francisco, CA11 days ago$201.3k - $373.8k
...Resourcing & Metrics within Business Strategy & Operations (BSO) is accountable for overseeing... ...priorities and day‑to‑day operational excellence in a dynamic and fast‑paced business... ...when interacting with colleagues in the global workplace. • Excellent verbal and written...For contractorsLocal area$281.01k - $363.66k
...Gilead Sciences seeks an Executive Director to lead its Procurement Center of Excellence from Foster City, California. This strategic role involves designing... ..., and integrating ESG initiatives across global operations. The position requires experience in procurement...$203k - $264k
...a team with urgency, excellence, and intention, and support... ...to the Senior Director, Head of Planning , the Director, Demand & Supply Planning will lead execution... ...across Technical Operations, CMC, Clinical Operations... ...Manufacturing, Clinical Supply Chain, and external partners...- ...The Director, Supply Chain is responsible for leading all sourcing, contract, and pricing negotiations... ...role ensures the Supply Chain team operates efficiently and effectively while... ..., integrity, safety, and operational excellence. The Director will develop and execute...Full timeContract workWork at office
CelLink Corporation
San Carlos, CA2 days ago $145k - $183k
...resource recovery and environmental services. Our client is looking for an experienced Senior Operations Manager to oversee day-to-day site operations, drive operational excellence, and lead a team of high-performing Operations Managers. If you bring a background in...Permanent employmentTemporary workWork experience placementWork at officeLocal areaShift workSan Francisco, CA5 days ago$180k - $200k
...Lakefront Biotherapeutics is a global biotech with offices in Belgium, Chicago... ...Rather than layers of hierarchy, we operate with small, empowered teams that work... ...Biotherapeutics is seeking an Associate Director of Clinical Supply Chain to plan and deliver investigational...Contract workWork at office2 days per week3 days per week$147.8k - $285.2k
...We design, build, and operate the world's largest autonomous... ..., delivering critical supplies quickly and reliably.... ..., restaurants and global businesses who rely on... ...system strengthens supply chains, reduces congestion, and... ...visibility. You excel at structured problem-solving...Local areaShift workDay shift$147.8k - $285.2k
...anywhere. We design, build, and operate the world's largest... ...system, delivering critical supplies quickly and reliably. Today,... ..., retailers, restaurants and global businesses who rely on us to... ...Our system strengthens supply chains, reduces congestion, and gives...Local areaZipline
South San Francisco, CAa month ago- ...'d love to have you join us. As the Global Supply Manager (GSM) at Bedrock Robotics, you... ...financial forecasting, and global supplier operations. Robotics systems integrate complex... ...Sustaining requirements. 5. Supply Chain Risk & Resilience Maintain a critical...Contract workShift workNight shiftEarly shift
Bedrock Robotics
San Francisco, CA3 days ago
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Director, Global Supply Chain - Operational Excellence (LEAN). Be the first to apply!
Related searches
- supply chain procurement manager South San Francisco, CA
- director supply chain planning South San Francisco, CA
- buying manager South San Francisco, CA
- director supply chain finance South San Francisco, CA
- procurement purchasing manager South San Francisco, CA
- supply chain purchasing manager South San Francisco, CA
- global sourcing manager South San Francisco, CA
- supply chain manager South San Francisco, CA
- supply chain project manager South San Francisco, CA
- global supply chain South San Francisco, CA