Remote Principal Clinical Scientist

Principal Clinical Scientist, ECD We are seeking a Principal Clinical Scientist to lead execution of key components of clinical development for our early cancer detection (ECD) program. This role is central to driving study design, clinical data review, and scientific insights across multiple studies. You will serve as a clinical science lead within cross-functional teams – partnering with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory to advance study execution and shape clinical strategy. Lead Clinical Development & Study Design Lead substantial aspects of ECD clinical studies or multiple studies Author and review protocols, ICFs, CRFs, and study documents Contribute meaningfully to clinical development strategy and study-level decision-making Contribute to process improvements and development of best practices Drive Data Review & Strategic Insight Lead medical and clinical data review to ensure data quality and integrity Analyze complex datasets to identify trends, risks, and opportunities Translate data into actionable insights that inform study and program decisions Partner with safety and medical teams on signal detection and escalation Collaborate with Clinical Operations, Biostatistics, Medical Affairs, and Regulatory Represent Clinical Science in internal and external forums (e.g., Drive Study Performance & Program Value Oversee enrollment, site performance, and key study metrics across studies Identify risks and proactively adjust study-level strategies Prioritize activities across studies to ensure quality, timelines, and program impact Advance Scientific Communication Translate clinical and statistical results into clear scientific narratives Advanced degree (PhD, PharmD, MD, or equivalent; 8–12 years of experience in clinical research, clinical science, or related field Strong experience leading clinical studies and contributing to study design Experience with clinical data review and interpretation Experience in oncology, diagnostics, or early cancer detection Track record of scientific publications and conference presentations Ability to lead complex clinical studies or multiple workstreams independently Strong analytical skills with ability to synthesize complex data into decisions Effective influencer across functions and senior stakeholders Excellent scientific communication skills The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. Remote USA $Natera™ is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. Email communications from all other domain names are not from Natera or its employees and are fraudulent. Natera does not request interviews via text messages and does not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. Natera takes cyber crimes seriously, and will collaborate with law enforcement authorities to prosecute any related cyber crimes. FBI Cyber Crime resource page Natera