Senior Clinical Scientist

• Provide scientific and clinical leadership for global clinical development activities in neurodegenerative disease, initially Parkinson’s disease and progressive supranuclear palsy
• Assemble, evaluate, interpret, and present scientific and medical data
• Lead or provide content for clinical documents
• Monitor the competitive landscape and critically review relevant literature
• Provide strategic input to clinical development programs and studies
• Design global Phase 1–3 studies with the clinical research physician
• Guide outcome-measure selection and interpretation, including MDS-UPDRS and PSP Rating Scale
• Contribute to data-collection tools, statistical analysis plans, case report forms, data-review plans, rater-training plans, and endpoint-quality strategies
• Collaborate with cross-functional study teams on study start-up, CRO and vendor selection, laboratory and imaging onboarding, rater qualification, and committee activities
• Lead clinical study protocols and contribute to investigator brochures, clinical study reports, safety update reports, regulatory documents, presentations, and publications
• Provide senior clinical-science leadership from study start-up through closeout
• Lead medical monitoring and clinical data-review plans
• Analyze efficacy, safety, biomarker, imaging, pharmacokinetic, and pharmacodynamic data
• Support dose selection, study adaptation, program strategy, benefit-risk interpretation, and recommendations to leadership, committees, investigators, and regulators
• Build relationships with investigators, key opinion leaders, patient advocacy organizations, clinical research networks, and external partners
• Support advisory boards and investigator meetings
• Travel domestically and internationally, approximately 20%

Requirements

• 10+ years of relevant pharmaceutical or biotechnology clinical-development experience
• Substantial experience with global interventional studies and demonstrated leadership of early-phase clinical development
• Equivalent combinations of education and experience will be considered
• Clinical-development experience in neurodegenerative disease or movement disorders required
• Strong knowledge of ICH-GCP, drug-development processes, study design, statistics, clinical operations, and global regulatory expectations in neurodegenerative disease
• Working knowledge of longitudinal efficacy endpoints, clinical rating scales, rater variability, disease progression, placebo effects, missing data, and operational challenges in neurodegeneration trials
• Excellent project leadership, communication, and organizational skills
• Ability to lead matrix teams, exercise independent judgment, and influence program-level and cross-functional decisions
• Ability to interpret complex clinical and biomarker data and communicate conclusions, limitations, and recommendations to technical and nontechnical audiences
• Strong team orientation and ability to work independently and reliably deliver high-quality objectives on time
• Ability to use a computer and communicate via phone, video, and electronic messaging
• Ability to maintain general availability during standard business hours
• Ability to work without current or future visa sponsorship
• Advanced scientific or clinical degree required
• Doctoral-level degree such as PhD preferred; MSc/MPH with extensive directly relevant experience may be considered

Core Competencies

Demonstrates extensive expertise in clinical development for neurodegenerative diseases, with a strong focus on study design, regulatory compliance, and data analysis. Proven ability to lead cross-functional teams and communicate complex scientific information effectively.

Highest-signal resume keywords

• Clinical Development Leadership
• Neurodegenerative Disease Expertise
• ICH-GCP Knowledge
• Project Leadership
• Data Analysis and Interpretation

Hard Skills

• Clinical Study Design
• Statistical Analysis
• Data Collection Tools
• Efficacy Endpoint Analysis
• Regulatory Document Preparation
• Clinical Protocol Development
• Biomarker Data Analysis
• Pharmacokinetic Analysis
• Phase 1-3 Study Management
• Clinical Operations

Soft Skills

• Communication Skills
• Organizational Skills
• Team Orientation
• Independent Judgment
• Influencing Skills

Certifications & Qualifications

• Advanced Scientific or Clinical Degree
• Doctoral-Level Degree (PhD Preferred)

Industry Keywords

• Neurodegenerative Disease
• Movement Disorders
• Global Interventional Studies
• Clinical Research
• Regulatory Expectations
• Clinical Rating Scales
• Study Adaptation
• Patient Advocacy Organizations
• CRO Selection
• Clinical Development Processes