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Research Scientist - CAR-T Cell Therapy & Immunology

Cube Hub Inc.

Research Scientist – CAR-T / Immunology (Cell Therapy)

Santa Monica, CA (Onsite – 5 days/week)

Contract Role (1 Year)

We are seeking a highly motivated Research Scientist with expertise in Immunology and CAR-T cell therapy to support cutting-edge solid tumor and cell therapy research programs. This role is part of a fast-paced translational research environment supporting Pre-IND/IND-stage cell therapy development.

The ideal candidate will have strong hands-on experience in T cell biology, cell-based assays, and immunological techniques, with the ability to independently design experiments, analyze data, and contribute to cross-functional scientific programs.

Key Responsibilities

Culture, maintain, and perform QC of solid tumor cell lines

Perform primary T cell isolation, activation, expansion, and engineering

Engineer and characterize CAR-T cell function in vitro

Conduct immunology and molecular assays including:

Flow cytometry (multi-color; FACSDiva, FlowJo)

qPCR / ddPCR

ELISA / Luminex / MSD assays

Cytotoxicity and proliferation assays (e.g., xCELLigence, eSight)

Design and execute hypothesis-driven and fit-for-purpose experiments

Analyze, interpret, and present experimental results using GraphPad Prism, Excel, FlowJo

Maintain accurate and detailed lab records (Benchling experience preferred)

Collaborate with cross-functional teams across research and development

Support time-sensitive Pre-IND/IND research activities

Required Qualifications

Bachelor’s or Master’s degree in Cell Biology, Immunology, Biotechnology, or related field

2+ years (MS) or 4+ years (BS) of relevant industry/academic experience

Hands-on experience with:

T cell culture and functional assays

Flow cytometry (multi-parameter analysis)

Molecular biology techniques (qPCR, ddPCR)

Strong experimental design, data analysis, and interpretation skills

Excellent attention to detail and scientific documentation skills

Strong written and verbal communication abilities

Preferred Qualifications

Prior CAR-T cell therapy experience (highly preferred)

Experience in solid tumor immunology

Exposure to ex vivo CAR-T manufacturing workflows

Experience with Benchling ELN

Familiarity with advanced immunoassays and cell-based potency assays

Ability to work in a fast-paced biotech environment with shifting priorities

Why This Role?

Work on next-generation CAR-T therapies for solid tumors

Be part of innovative translational research (Pre-IND stage)

High-impact role contributing to cancer immunotherapy advancement

Collaborative, cross-functional biotech environment

Vacancy posted 2 days ago
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