Scientist

What You Will Do Conduct microdissections of human vessels, prepare tissue for single‑cell analysis of vascular cells, genetically manipulate human vessels, and assess function through molecular, imaging, and physiologic evaluations. Culture vascular cells, prepare cells for single‑cell analysis, perform genetic manipulation of cultured cells, and assess function using molecular, imaging, and physiologic evaluations. Develop, refine, and perform microdissections of human blood vessels from tissue specimens for IRB‑approved or exempt studies. Develop, refine, and conduct vascular cell culture and co‑culture methods, and optimize approaches for studying human vessels and cultured cells at the single‑cell level in IRB‑approved or exempt studies. Characterize cultured cells using imaging, gene expression, and/or molecular sensors. Perform vascular phenotyping of rodent models, including mouse models of human diseases or conditions. Perform biochemical characterization of protein‑protein interactions involved in vascular cell signaling. Work with staff on the interpretation of experiments performed by research scientists. Independently direct and conduct special research projects that have a high priority for the laboratory with special emphasis on the development of novel research treatments. Calibrate, maintain and troubleshoot instruments and equipment in the laboratory. Manage scientific equipment and resources, including reagents, frozen cell stocks, and animal samples, by overseeing acquisition, documentation, and storage. Write technical reports and prepare manuscripts. Oversee project data quality; analyze and interpret project data. Maintain a detailed and up‑to‑date electronic laboratory notebook detailing all experiments. Develop and evaluate pharmacologic strategies that target protein‑protein interactions to alter vascular function in human vessels, cells, or animal models of vascular physiology or disease. Prepare oral presentations and posters for internal and external groups/conferences. Co‑author manuscripts on research projects; publish in peer‑reviewed journals. Write papers and abstracts detailing research efforts and results for publication in peer‑reviewed journals; prepare PowerPoint presentations as appropriate. Produce research reports and regularly communicate results to staff and collaborators. Train staff on proper equipment use and a broad range of laboratory techniques. What You Will Need Master’s degree in Biochemical Sciences or related field. A minimum of six (6) years of laboratory research experience. Experience with cell culture and vascular biology research techniques. Proficiency with Microsoft Office Suite (PowerPoint, Outlook, Excel, Word). Knowledge of Good Clinical Practice (GCP). Ability to analyze and interpret complex scientific data and produce technical reports. Strong written and verbal communication skills, including scientific publishing and presentations. Ability to work independently and collaboratively in a research laboratory environment. Must be able to obtain and maintain a Federal or DoD “public trust”; candidates must receive approved adjudication prior to onboarding with Guidehouse. Candidates with an active public trust or suitability are preferred. What Would Be Nice To Have Experience with single‑cell analysis techniques. Experience working with rodent models of disease. Background in genetic manipulation and molecular biology techniques. Experience presenting at national scientific meetings or publishing in peer‑reviewed journals. Prior experience mentoring or training laboratory staff. Salary & Benefits The annual salary range for this position is $130,000.00 – $216,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience, and training. Benefits include: Medical, Rx, Dental & Vision Insurance Personal and Family Sick Time & Company Paid Holidays Parental Leave 401(k) Retirement Plan Group Term Life and Travel Assistance Voluntary Life and AD&D Insurance Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts Transit and Parking Commuter Benefits Short‑Term & Long‑Term Disability Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities Employee Referral Program Corporate Sponsored Events & Community Outreach Care.com annual membership Employee Assistance Program Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.) Position may be eligible for a discretionary variable incentive bonus. EEO Statement Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation. Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco. #J-18808-Ljbffr US132 Guidehouse Digital, LLC