Associate Scientist, Protein Engineering & Binder Optimization

Job Title Associate Scientist Job Description We are seeking a highly motivated and detail‑oriented Associate Scientist to join the Protein Engineering & Binder Optimization group within Kite Research. This role is primarily bench‑focused and execution‑driven, with a strong emphasis on hands‑on laboratory support for high‑throughput protein expression, purification, and analytical characterization. The Associate Scientist will be a critical contributor to discovery and optimization programs, serving as a reliable experimental operator who enables scale, speed, and data quality across multiple protein engineering efforts. This position is well‑suited for an individual who thrives in a fast‑paced research environment, values rigor and reproducibility, and is excited to build deep technical expertise in protein production and analytics. Key Responsibilities High‑Throughput Protein Expression & Purification (Primary Focus) Execute high‑throughput cloning, expression, and purification of recombinant proteins and binders across multiple formats (e.g., bacterial, mammalian, or yeast systems, as applicable). Perform parallelized small‑scale and mid‑scale protein production to support binder discovery and optimization workflows. Prepare purified proteins for downstream applications, ensuring appropriate quality, concentration, and documentation. Rigorously track samples, constructs, and yields using electronic lab notebooks and sample management systems. Protein Characterization & Analytics Perform routine and advanced protein analytical assays, such as SDS‑PAGE, SEC, ELISA, and concentration/quality assessments. Support binding and functional characterization efforts (e.g., sample preparation for SPR/BLI, cell‑based assays, or functional screens). Assess protein quality, stability, and suitability for downstream assays; flag issues and propose troubleshooting steps. Experimental Execution in Discovery Programs Provide consistent, high‑quality experimental execution in support of binder discovery, optimization, and validation campaigns. Work from protocols while developing the technical judgment to recognize deviations, failures, or optimization opportunities. Generate clear, reproducible, and decision‑ready experimental data that feeds directly into program workflows. Workflow Support & Continuous Improvement Contribute to the robustness and scalability of protein production and analytical workflows. Identify opportunities to improve throughput, reproducibility, or data quality through protocol refinement and standardization. Maintain well‑organized lab spaces, reagents, and shared resources to support efficient team operation. Collaboration & Communication Collaborate closely with Scientists and computational partners within the larger Protein Science team. Communicate experiment status, results, and issues clearly in team discussions and written records. Engage constructively with cross‑functional partners (e.g., Cell Biology, Translational teams) as needed for sample handoff and assay support. Basic Qualifications Master’s degree with 2+ years of relevant scientific experience OR Bachelor’s degree with 4+ years of relevant scientific experience Preferred Qualifications Bachelor’s or Master’s degree in Biochemistry, Molecular Biology, Protein Science, Bioengineering, or a related discipline. Hands‑on laboratory experience in recombinant protein expression and purification. Demonstrated ability to execute repetitive, high‑throughput wet‑lab workflows with accuracy and consistency. Strong attention to detail and commitment to data quality and experimental traceability. Experience with parallelized or automated protein expression/purification workflows. Familiarity with common protein analytics and characterization methods (e.g., SEC, ELISA, biophysical assays). Experience working in electronic lab notebooks and sample/LIMS systems. Prior experience supporting protein engineering, antibody, or binder discovery programs. Attributes for Success Highly reliable experimental executor who takes pride in high‑quality bench work. Organized, methodical, and comfortable managing multiple samples and workflows in parallel. Learns quickly from feedback and adapts to evolving experimental needs. Collaborative team member who enables the productivity of Scientists and program teams. Motivated to build deep technical expertise in protein expression, purification, and analytics within a discovery research environment. Salary Range Salary range for this position is: $109,650.00 - $141,900.00. Compensation may vary based on experience, qualification, and geographic location. Benefits Eligible employees may participate in benefit plans, subject to the terms and conditions of the applicable plans. Benefits include company‑sponsored medical, dental, vision, and life insurance plans. Equal Employment Opportunity Statement Kite Pharma is committed to providing equal employment opportunities to all employees and applicants for employment, and is dedicated to fostering an inclusive work environment comprised of diverse perspectives, backgrounds, and experiences. Employment decisions regarding recruitment and selection will be made without discrimination based on race, color, religion, national origin, sex, age, sexual orientation, physical or mental disability, genetic information or characteristic, gender identity and expression, veteran status, or other non‑job related characteristics or other prohibited grounds specified in applicable federal, state and local laws. In order to ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Era Veterans' Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact View email address on click.appcast.io for assistance. Additional Comments For jobs in the United States, applicants may contact the internal career portal for current employees. This position does not require a visa sponsorship. All research is conducted in accordance with institutional and regulatory guidelines. #J-18808-Ljbffr Kite Pharma