Principal Investigator (MD/DO)

Help Build a New Clinical Research Site From the Ground UpAt Alliance Clinical Network, we're advancing medical innovation through high-quality, patient-centered clinical research. Our growing network is built around a simple belief: great research starts with great people, strong clinical leadership, and a commitment to doing what's right for patients.We're looking for an Internal Medicine / Family Medicine / Specialist physician (MD/DO) with clinical research experience who wants to play a meaningful role in bringing that mission to life in Oklahoma City.This is more than an opportunity to serve as a Principal Investigator. Help establish a brand-new research site and play a visible role in shaping its clinical and research presence in the community.As Principal Investigator, you will provide medical oversight and clinical leadership for assigned clinical trials, with patient safety and data quality at the center of your work.Serve as the study physician and provide medical oversight for assigned clinical trials.Protect the safety, rights, and well-being of research participants throughout the study.Review and confirm participant eligibility and provide medical oversight of screening outcomes.Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.Perform or oversee study-specific medical assessments, including medical histories, physical examinations, concomitant medications, and endpoint assessments.Provide clinical guidance and medical oversight to Sub-Investigators, Clinical Research Coordinators, RNs, and other site staff.Serve as a clinical resource for study-related medical questions and safety concerns.Collaborate with study sponsors, CROs, IRBs, and Alliance leadership throughout the life of each trial.Participate in Site Initiation Visits, monitoring visits, close-out activities, and other study meetings as needed.Review clinical data including laboratory results, ECGs, vital signs, and other study-specific assessments.Support timely safety reporting, medical documentation, and resolution of clinical data queries.Maintain compliance with study protocols, site SOPs, ICH-GCP, FDA regulations, and applicable requirements.Contribute to a culture of quality, continuous improvement, and patient-centered research.A Schedule Designed Around Your LifeOpportunity to transition into the role from your current work; starting at approximately 10 hours per week and moving to full-timeNo overnight call & rare urgent escalationsPredictable research visits and structured protocolsFocused interactions with study participants rather than a traditional high-volume clinicA dedicated research team managing day-to-day study coordinationTraining & SupportStructured PI onboarding and mentorshipProtocol-specific trainingSupport from other experienced Principal InvestigatorsOngoing partnership with clinical operations, regulatory, and quality teamsEstablished SOPs, templates, and documentation workflowsContinued support throughout the life of your studiesWhat We're Looking ForRequirementsMD or DO with a background in Internal Medicine, Family Medicine or a SpecialistActive, unrestricted Oklahoma medical licensePrior clinical research experience in a Principal Investigator, Sub-Investigator, or other clinical research physician capacity is requiredStrong clinical judgment and commitment to participant safetyInterest in clinical research and advancing medical innovationComfort reviewing structured clinical data and study-specific medical informationStrong communication, documentation, and confidentiality practicesFamiliarity with ICH-GCP and FDA clinical research regulationsBoard certificationDEA registration, if required by applicable study protocolsBuild Something That MattersIf you're an Internal Medicine / Specialist physician looking for a way to stay engaged in medicine, contribute to the advancement of new therapies, and have a meaningful role in building something new - we'd love to talk with you. This is an opportunity to bring your medical & clinical research expertise to a greater patient population & new clinical research site.Help us build the future of clinical research in Oklahoma City!