PRINCIPAL SCIENTIST- (Protein Immunotherapy)

ABOUT US:Calibr-Skaggs Institute for Innovative Medicines, a division of Scripps Research, is a first-of-its-kind, nonprofit translational research institute dedicated to creating the next generation of medicines. Calibr-Skaggs was founded on the principle that the creation of new medicines can be accelerated by pairing world-class biomedical research with state-of-the-art drug discovery and development capabilities. Scripps Research is ranked one of the most influential institutions in the world for its impact on innovation. Our educational and training programs mold talented and committed students and postdocs into leading edge scientists. Leveraging the unique scientific environment of Scripps Research, impacting translational sciences, Calibr-Skaggs has created a portfolio of drug candidates, and is shaping a new paradigm for advancing nonprofit biomedical research to impact patients while re-investing in further innovative research. We expand basic knowledge in the biosciences and use these fundamental advancements to develop profound innovations that improve wellbeing. Calibr-Skaggs’ drug development portfolio spans a broad range of human diseases, including cancer, autoimmunity and inflammatory diseases, metabolic and cardiovascular diseases, infectious and neglected diseases, as well as age-related and degenerative diseases. If you have a passion for making a difference, this could be your opportunity to join our transformative team.POSITION TITLE: Principal Scientist (Protein Immunotherapy)JOB SUMMARY: Calibr is seeking a talented Principal Research Scientist in the area of Protein Immunotherapy. This position will work as part of an interdisciplinary team to translate innovative protein therapies for the treatment of inflammation, autoimmunity and cancer, moving programs from ideation into first-in-human clinical trials. Specifically, projects will be focused on the development of next generation multi-specific antibodies to control complex immune cell pathways in cancer and inflammatory diseases. While working within the scope of these projects, this position will also have the unique opportunity to explore novel ideas within the scope of the broader portfolio, from aging to infectious disease. Calibr’s open lab space design and collaborative environment encourage the seamless flow of ideas within and between research groups. This position will receive hands on training in translational research and gain knowledge on how scientific ideas are translated into drugs to help patients in need. The ideal candidate is expected to bring the basic scientific proficiencies listed below at the start. This position offers significant growth opportunity through promotion structures designed to retain exceptional talent within the Calibr family. This position will require training and managing entry level Research Associates, with increased responsibility over time. ESSENTIAL RESPONSIBILITIE & DUTIES: Design and execute project plans focused on comprehensive immune profiling using flow cytometry, including signaling pathway characterization, xenograft-derived cell processing, and functional assays such as cytotoxicity, proliferation, activation, and survival assays.Perform cell biology workflows involving the isolation, characterization, and assay development of primary human and murine cells, immune and tumor cell lines relevant to immuno-oncology research, and primary patient-derived cells.Design, develop, and characterize antibody-based therapeutics, including bi-specific and multi-specific antibodies.Apply automation technologies to support high-throughput antibody screening in primary cell-based assays.Conduct gene editing of primary human immune cells using advanced platforms such as CRISPR, TALEN, and other endonuclease technologies, utilizing diverse delivery methods including protein and mRNA electroporation as well as viral vector systems.Effectively manage a team of PhD trained scientists to deliver on goals.Prepare reports and present experimental findings during regular team and project meetings.POSITION REQUIREMENTS: Bachelor’s degree in Biology, Chemical Biology, Biochemistry, or a related field required; PhD strongly preferred.Minimum of 10+ years of industry experience required.Demonstrated exceptional attention to detail, with strong hands-on experience in experimental execution, research, study design, and maintaining thorough scientific documentation.Highly motivated, creative, and committed to achieving project objectives.Strong collaboration and communication skills, with the ability to work effectively across scientific and cross-functional teams.Capable of making meaningful contributions to scientific discussions and broader research strategy.QUALIFICATIONS & EXPERIENCE: Strong background in Immunology with a proven publication record is essential.Hands-on experience with in vitro assays (co-culture, signaling, activation assays) using primary human immune cells is essential.A strong background in cell culture and multi-color flow cytometry is essential.Experience with genomic data analysis is essential.Knowledge and hands-on expertise in protein engineering, antibody design and characterization are preferred.Experience with laboratory automation systems and high-throughput flow cytometry platforms is preferred.Experience with gene editing technologies, as well as cell transfection and transduction systems, is preferred.PHYSICAL REQUIREMENTS: This position works in a laboratory or vivarium environment. Details of established essential functions for this position will be addressed/discussed during the interview process.COMPENSATION: The expected hiring range for this position is $120,000- $150,000 per year, commensurate with experience. Consideration will be given to experience that exceeds the listed requirements. COMPREHENSIVE BENEFITS INCLUDE:Eligibility for retirement plans with employer contribution.Full suite of Health and Welfare plans including three medical plan options (including an HSA available option), dental, vision, life insurance, disability, EAP and more.Access to Flexible Spending Accounts (Medical/Dependent Care).Competitive vacation and sick leave policies.Free, on-site Counseling Center which provides confidential counseling services to benefits-eligible employees and their family members.Free, on-site parking. The above statements describe the level of work performed and expected in general terms. The statements are not intended to list all the responsibilities, duties and/or skills required of employees so classified, and the content herein is subject to change due to the business needs of Scripps Research, with or without notice. Furthermore, nothing in this job description shall be interpreted to be in conflict with or to eliminate or modify in any way the employment-at-will status of Scripps Research staff. EEO Statement: The Scripps Research Institute is an Equal Opportunity Employer. We promote diversity of thought, culture and background in the fields of science. All qualified applicants are encouraged to apply and will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, protected veteran status, or any other legally protected characteristic or status. Job SummaryRequisition Number: PRINC004995Job Category: Scientific StaffSchedule: Full-Time