Research Fellow

Research Fellow Position

The laboratory of Dr. Sarah Urbut is located within Mass General Brigham's Heart and Vascular Institute's (MGB HVI) Cardiovascular Research Center (CVRC) and also is affiliated with the Broad Institute of Harvard & MIT and Harvard Medical School. Dr. Urbut leads cutting-edge research in principled method development to integrate electronic health records (EHR) with genetics for both prediction and discovery.

The Urbut Lab has a unique research fellow position open for a highly qualified applicant interested in dynamic modeling using multimodal data and causal inference for Bayesian analysis of EHR across cohorts, hospital-based biobanks, and within clinical trials. The new hire will be appointed as a Research Fellow at the Massachusetts General Hospital and at Harvard Medical School.

This position will leverage stimulating environments and resources across world-class institutions. Individuals will work with a range of genetic datasets, including genome-wide arrays, whole exome sequencing, and whole genome sequencing, as well as multi-omics data (e.g., metabolic, transcriptomic, proteomic, methylation). The successful candidate(s) will join an interdisciplinary team of computational biologists, bioinformatics analysts, epidemiologists, physicians, nurses, clinical research coordinators, and students. Please visit surbut.github.io/Urbut_lab (in process) for additional details about prior, ongoing, and future research.

The high prevalence of cardiovascular disease, the leading cause of premature death worldwide, coupled with increasingly massive patient and genetic data, has motivated the Urbut Lab to pursue highly innovative research studies to guide future therapeutic development and diagnostic tools. The successful candidate will work closely with members of the Urbut Lab as well as Dr. Urbut directly. The successful candidate will be closely supervised by Dr. Urbut. The successful candidate will have robust facility in computational genetics and biostatistics. Projects will range from genomic discovery and in silico investigations of genetic mechanisms of disease risk prediction, digital twin development, and genomic discovery through multi-feature hypothesis-generating studies with multi-omics, imaging, and electronic health records. Overall, this is a unique opportunity to engage in cutting-edge science and make a central contribution to biomedical research.

In addition, Mass General Brigham, Massachusetts General Hospital, and the Broad Institute provide vibrant research environments with close links to top academic and industry networks across the Greater Boston area and the world.

Key Responsibilities:

• Construction and implementation of cloud-based pipelines for genomic, polygenic risk scoring, and biostatistical analyses.
• Processing and quality control of next-generation sequence data.
• Processing and quality control of multi-omics data.
• Statistical analyses of genotype-phenotype association analyses, with summarization and graphical representations.
• Organizing, manipulating, and harmonizing new datasets across different formats and robust synchronization with existing datasets and databases.
• Phenotypic derivation from electronic health record structured and unstructured data.
• Construction, implementation, and sensitivity analyses of biostatistical models in classical epidemiology, genetic epidemiology, and machine learning.
• Lead and contribute to manuscript preparation as well as internal and external project-team reports.
• Actively participate and present in project meetings.

Work will be performed in the Simches Research Building on the Massachusetts General Hospital main campus, in Boston, MA.

Qualifications:

• First (or co-first) author of one or more peer-reviewed scientific publications
• Excellent English verbal and written communication skills
• Able to work both independently and in a team
• Doctoral degree in computational biology, biomedical informatics, biostatistics, statistical genetics, genetic epidemiology, or computer science.
• Strong record of productivity, motivation, adaptability, and collaboration.
• Exceptional oral and written communication skills.
• Strong background in computational biology and bioinformatics.
• Strong skills in statistical analyses are highly preferred.
• Strong demonstrable proficiency in Linus, R, python and AWS use.
• Strong facility with cloud computing.
• Prior experience in human genetic analyses and bioinformatics analyses of publicly available datasets.
• Familiarity with next-generation sequence data analysis tools strongly preferred.
• Ability to adapt to rapidly changing and high-demand environments.
• Knowledge of cardiovascular disease is not required.

The salary for this position ranges from $73,544-$81,179.

Additional Job Details (if applicable):

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• Cover letter

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Remote Type

Onsite

Work Location

185 Cambridge Street

EEO Statement:

1200 The General Hospital Corporation is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran's Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at View phone number on click.appcast.io.