Principal Scientist
Disc Medicine
Disc Medicine, a clinical-stage biopharmaceutical company in Watertown, MA, seeks a detailed-oriented Principal Scientist/Associate Director to lead discovery and design of biologics across stages. You will steer protein production, develop assays, and guide developability assessments in a fast-paced Innovation portfolio. You will communicate updates to cross-functional teams and advance pipeline programs, with a focus on antibodies and multi-specifics, while contributing to a collaborative, #J-18808-Ljbffr Disc Medicine
$137k - $215.27k
...information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Pharmacovigilance Scientist, Senior Scientist ensures regulatory compliance and safety of Takeda's products by managing large projects, developing innovative...PrincipalMinimum wageLocal area$115k - $215k
...quantitative proteomics data analysis tools.Domain leadership with cross-functional drug discovery:Highly organized, solutions-oriented scientist with the ability to manage multiple priorities simultaneously while driving innovation in targeted proteomics workflows and...Principal- ...development, scale‑up, and technology transfer for small molecule oral dosage forms across all development stages. You will mentor scientists, drive cross‑functional CMC/regulatory activities, and advance enabling formulation strategies to improve portfolio execution and...Principal
$146k - $236k
About Pioneering IntelligencePioneering Intelligence builds on Flagship Pioneering’s legacy of founding cutting-edge science and computational ventures, harnessing recent advances in AI, machine learning, and data to accelerate fundamental research and create a portfolio...Principal$148.5k - $214.5k
Job title: Senior Principal Scientist/Principal Scientist, Real-World Evidence & Disease GenomicsLocation: Cambridge, MAAbout the JobJoin Sanofi's Target, Disease and Systems Biology (TDSB) team and become a key contributor to our Disease Genetics and Genomics cluster....PrincipalFull time- UCB in Cambridge, MA is seeking a Senior Principal Scientist to lead translational biology drug discovery with emphasis on muscle biology. You will shape in vitro and in vivo models and develop cellular and biochemical assays for early programs across multiple neuromuscular...Principal
$179k - $236k
...nonclinical and clinical programs, operating as a hands-on scientific leader. We are looking for an accomplished DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method development, and translational biomarker strategy. This person will...Principal$188k - $259k
...internal and external manufacturing sites. Provide strategic oversight and establish manufacturing strategies. Mentor and develop scientists and engineers supporting oral drug product development. Oversee completion of drug product sections for regulatory submissions...PrincipalFull timeTemporary workLocal area$122.25k - $176.58k
Job title: Principal ScientistLocation: Waltham, MAAbout the JobThe Genomic Medicine Unit (GMU) CMC group at Sanofi is dedicated to the... ...Group located in Waltham, MA in the role of Senior Scientist. The Genomic Medicine Cell Therapy Development group within Sanofi...PrincipalFull time$147.2k - $220.8k
...therapeutics and other emerging modalities. The candidate will work closely with colleagues across Research and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership and strategic guidance to advance...PrincipalFull timeTemporary workWork at officeLocal areaFlexible hours$159k - $200k
...improvement for individuals, families and communities. Learn more at , and follow us on X, LinkedIn and Facebook.Role SummaryThe Principal Scientist of Oligonucleotide Development will lead the chemical synthesis strategy for PMO and modified ASO payload molecules, managing...PrincipalFor contractorsLocal areaRemote workShift work$119.7k - $222.3k
Job Description SummaryLocation: Cambridge MAInternal: Principal Scientist I/IILI#-HybridThe individual will provide scientific and operational support to Study Quality and Compliance group within the Toxicology line function of Preclinical Safety (PCS). Key areas of responsibility...PrincipalPermanent employmentFull time$126k - $234k
...of treatment approaches including targeted therapies, immunotherapies, CAR-T, and radioligand therapy. NIBR is seeking an in vivo scientist to join our Oncology Pharmacology team in Cambridge, MA. The successful candidate will join a dynamic, multi-disciplinary team and...PrincipalFull timeRemote work$122.25k - $176.58k
Job Title: Principal Scientist, Systems and Disease BiologyLocation: Cambridge, MAAbout the JobAs a Principal Scientist within our Systems and Disease Biology Cluster, you will decode disease mechanisms at cellular resolution and pioneer AI-powered workflows that accelerate...PrincipalFull time$142.5k - $256.5k
..., as a shared discovery resource. This role is intended for a scientist ready to own and evolve a core discovery capability, led by scientific... ...independence, judgment, and ownership consistent with a Principal Scientist role.Here’s What You’ll Bring to the Table (...PrincipalPermanent employmentFull timeWork at officeWork from home$142.5k - $256.5k
The RoleThe Therapeutics Research group at Moderna is seeking a talented, experienced, and highly motivated Principal Scientist to build, optimize, and execute T cell receptor optimization workflows for next-generation TCR-based therapeutics.This individual will lead the...PrincipalPermanent employmentFull timeWork at officeWork from home$119.7k - $222.3k
...preferably in a lead role overseeing ADME/DMPK project strategy in clinical development, or in AI strategy, to be considered for Principal Scientist II. 4+ years of experience to be considered for Senior Principal Scientist.Extensive and in-depth knowledge of...PrincipalFull time$216k - $297k
...reasoning efforts on both the technical and application levels. You will be a hands-on lead for a team of talented machine learning scientists innovating on model architectures that will create best-in-class biological reasoning engines. You will be responsible for...Principal$142.5k - $256.5k
The RoleModerna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research. Therapeutics Research generates innovative therapeutic concepts and advances them from early scientific idea through First...PrincipalPermanent employmentFull timeWork at officeWork from home$208k - $286k
...elevating the AI advances happening across the ecosystem in human health, sustainability, and beyond. THE ROLE We are seeking a Principal Scientist (Embedded ML/Computational) to lead AI/ML and computational projects that accelerate pharmaceutical R&D across the...Principal$141k - $188k
About This Role The Biomarkers and Systems Biology group is seeking a highly motivated Principal Scientist to contribute to the development and implementation of biomarker and bioanalytical strategies supporting discovery, translational, and clinical-stage programs. The...PrincipalFull timeTemporary workLocal areaFlexible hours- ...discovery, preclinical, clinical, safety, and real-world evidence with scalable data products and governance. You will partner with scientists, knowledge architects, AI engineers, and platform teams to define a future-state data ecosystem and deliver high-quality,...Principal
- ...GSK Oligonucleotide Conjugation Scientist At GSK, we have bold ambitions for patients, aiming to positively impact the health of 2.5 billion people by the end of the decade. Our R&D focuses on discovering and delivering vaccines and medicines, combining our understanding...PrincipalFull time
- ...innovative, agile, and offers every team member the opportunity to drive a big impact. THE ROLE We’re looking to hire a Principal Scientist in Bioengineering or Biology for ODDITY LABS with a strong focus on anti-aging or skin. In this role, you will: Work...PrincipalWork at officeShift work
- Zealand Pharma in Cambridge, MA seeks a Principal Scientist to lead the DMPK/ADME strategy for complex drug modalities and to build discovery platforms and bioanalysis capabilities. You will shape strategy, culture, and technical excellence from the ground up. You will...Principal
- GSK in Cambridge, MA is seeking a PhD-level chemist to help establish pre‑clinical oligonucleotide conjugation capabilities for ASOs, siRNA, SSO, and RNA editors with small molecules, lipids, and linkers. The role covers method development from milligram to gram scale and...Principal
- Johnson & Johnson is seeking a Principal Scientist, Animal Genetic Engineering - Antibody Discovery, to design and engineer mouse models for advanced antibody discovery. Based in Cambridge, MA or Spring House, PA, the role integrates mouse genetics, CRISPR, B cell immunology...Principal
$120k - $180k
Predicta Biosciences Inc. is seeking an experienced R&D Scientist to lead assay development spanning flow cytometry and NGS, including single-cell techniques. The role involves designing multi-color panels, optimizing library preparation, and translating research concepts...PrincipalFull timeWork at office$170k - $200k
...Opportunity to make a significant impact on the development of novel therapeutics Work with a talented and passionate team of scientists Be a part of a cutting-edge company that is revolutionizing drug discovery Psivant Therapeutics, Inc. (d/b/a PsiThera) is...Principal- ...Direct message the job poster from GForce Life Sciences Executive MSP Recruiter at GForce Life Sciences Principal Associate Scientist 12-month Contract Onsite in Cambridge, MA Key Responsibilities Compound Management (50%) • Process compound...PrincipalContract workPart time
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