Senior Scientist II, siRNA Therapeutics - Oncology

Senior Scientist II, siRNA Therapeutics – Oncology Full-time Salary Min: 109500 Salary Max: 208500 Workday Global Grade: 18 Travel: Yes, 5% of the Time Compensation: USD 109,500 – USD 208,500 – yearly Responsibilities Lead and execute in vitro siRNA discovery and proof‑of‑concept activities, including target validation, assay development and optimization, siRNA screening, lead optimization, and mechanism‑of‑action studies to support active therapeutic programs for oncology. Develop, validate and execute robust siRNA‑based in vitro screening funnels for hit‑to‑lead identification to support siRNA‑based drug discovery projects (eg. 96‑well RNA isolation, qPCR, westerns, ELISA, flow cytometry, reporter assays, RNA‑seq, microscopy and others). Identify and resolve key biological and technical pitfalls related to siRNA activity, delivery, stability, and on‑target and off‑target effects. Collaborate with cross‑functional partners and external CROs, including chemistry, delivery, bioinformatics, and in vivo biology teams, to advance siRNA candidates through key discovery milestones. Work with oncology therapeutic area colleagues to support target selection and internal siRNA pipeline development. Design in vivo studies (PK/PD, biodistribution, and efficacy) to assess siRNA potency, specificity, durability, and mechanism. Maintain updated and well‑organized ELNs and ensure high scientific rigor, reproducibility, and data integrity. Publish research in peer‑reviewed journals and present work at scientific conferences. Proactively seek out new information in the literature and incorporate this into individual projects as well as the overall program. Generate new scientific proposals and lead those efforts. Required Qualifications PhD, MS, or BS in cell biology, molecular biology, biochemistry, pharmacology or related field with typically 4‑5+ (PhD), 10+ (MS), or 12+ (BS) years of relevant experience. (Postdoctoral or industry experience in RNA biology/therapeutics preferred.) Strong understanding of RNAi biology and drug discovery processes with hands‑on experience in siRNA therapeutic discovery is required, including leading in vitro siRNA studies that informed program go/no‑go decisions and support development candidate nomination. Strong hands‑on experience with molecular biology techniques (eg. stem‑loop RT‑qPCR and RT‑qPCR), including assay design, optimization, validation, and data interpretation for siRNA quantification and mRNA target knockdown. Extensive experience with mammalian cell culture and transfection techniques. Experience working with animal tissues would be a plus. Strong data analysis and critical thinking abilities. Excellent written and verbal communication skills, attention to detail, multi‑tasking and organizational skills, and the ability to collaborate effectively with a team. Strong presentation skills with the ability to clearly articulate scientific findings and project updates to project teams, senior leadership, and external stakeholders. Highly independent and productive in performing laboratory research or assay development, requiring only minimal direction from or interaction with supervisor. Desired Qualifications Prior experience in siRNA therapeutics, siRNA sequence design and optimization, target site selection, chemical modifications, and evaluation of structure‑activity relationships (SARs). Familiarity with tumor intrinsic biology and/or immune oncology. Experience working with tumor models would be a plus. Experience with extrahepatic oligonucleotide delivery technologies, particularly antibody‑oligonucleotide conjugates (AOCs), is highly desirable. Strong publication track record or IND‑enabling contributions. Ability to work in fast‑paced, collaborative environment. We offer a comprehensive package of benefits including paid time off (vacation, holidays, sick), medical/dental/vision insurance and 401(k) to eligible employees. This job is eligible to participate in our short‑term incentive program. This job is eligible to participate in our long‑term incentive program. AbbVie is an equal opportunity employer and is committed to operating with integrity, driving innovation, transforming lives and serving our community. Equal Opportunity Employer/Veterans/Disabled. #J-18808-Ljbffr Allergan