Director, Knowledge Graph & Semantics - HYBRID ROLE
$216.4k - $324.6kVertex Pharmaceuticals
- # Director, Knowledge Graph & Semantics - HYBRID ROLE**Job Description****This is a Hybrid position requiring 3 days a week in our Boston office**We are seeking an experienced engineering leader to build and operate Vertex's enterprise Knowledge Graph and Semantic Layer: the unified, navigable representation of Vertex's data, concepts, and relationships that AI agents and analytical systems traverse to reason over our business. Vertex Pharmaceuticals is in a transformational period, and the AI team is at the center of our AI-first strategy, delivering AI solutions that empower executives, researchers, and business users to make faster, more confident decisions.As part of the Vertex Data Engineering team, you will lead the Knowledge Graph & Semantics function within Knowledge & Grounding. Your team builds the graph that connects Vertex across clinical, research, regulatory, and commercial domains, and the AI semantic layer that defines the business meaning, metrics, and dimensions that sit on top of it. The capability you build becomes the substrate that AI agents traverse to ground their reasoning, and that analytical systems use to answer cross-domain questions consistently across the enterprise.As the Director of Knowledge Graph & Semantics, you will define the graph and semantic strategy for Vertex, select the underlying technology stack, and lead the engineering team that brings it to life.The capability you build will accelerate every downstream AI and analytics initiative at Vertex by giving them a single, governed, traversable model of how Vertex's data fits together.**Key Duties and Responsibilities:*** **Enterprise Knowledge Graph.** Design, build, and operate Vertex's enterprise knowledge graph spanning clinical, research, regulatory, and commercial domains, including ingestion, storage, query, and lifecycle management of nodes, edges, and properties.* **Semantic Layer.** Build and govern the enterprise semantic layer that enables metrics, dimensions, business entities, and relationships in a single, consistent model used by AI agents.* **Graph and Semantic Strategy.** Define Vertex's strategy for graph and semantic platform, including technology selection (graph database, AI semantic layer tooling, query API) and the architecture that unifies them.* **Ontology Partnership.** Partner with the ontology and data modeling function to translate domain ontologies into the graph, ensuring fidelity to source models and consistency across domains.* **Agent Traversal & Retrieval.** Build the graph traversal and retrieval interfaces that AI agents and other consumers use to ground their reasoning, including pattern queries, semantic search over graph context, and graph-aware retrieval for RAG systems.* **Application & System Onboarding.** Partner with application and system owners across Vertex to onboard their systems into the enterprise knowledge graph and semantic layer.* **Production Operations.** Own SLAs, observability, query performance, cost, and continuous improvement for the graph and semantic layer in production.**Knowledge and Skills:*** **Proven Experience.** 10+ years of experience in data engineering, AI/ML, or advanced analytics, with 3+ years specifically focused on knowledge graphs, semantic technologies, or enterprise data modeling at scale.* **Knowledge Graph Expertise.** Deep hands-on experience designing and operating enterprise knowledge graphs, including schema design, ingestion, query, and traversal patterns. Familiarity with multiple graph paradigms (property graph, RDF/semantic web, hybrid graph + vector approaches) and the trade-offs between them.* **Semantic Layer Expertise**. Strong experience building and governing semantic layers (e.g., dbt Semantic Layer, Cube, AtScale, LookML, or comparable) that serve analytics and AI consumers consistently.* **Cloud Data Platforms.** Strong experience with Snowflake and/or Databricks in enterprise environments, including how graph and semantic capabilities integrate with these platforms.* **Cross-Domain Data Integration.** Track record of integrating data across multiple business domains, including entity resolution, master data, and lineage at enterprise scale.* **AI & Agent Grounding.** Working understanding of how knowledge graphs and semantic layers are consumed by AI agents and RAG systems, including graph-aware retrieval and traversal for agent reasoning.* **Production Operations.** Track record of operating graph and analytical systems in production with high availability, query performance, and continuous improvement.* **Leadership & Communication.** Proven ability to lead technical teams, communicate with executive stakeholders, and translate business needs into graph and semantic models.**Preferred*** **Pharma or Life Sciences Context.** Experience in pharmaceutical, biotech, or life sciences data environments. Familiarity with clinical, regulatory, and commercial data domains is a plus.* **Regulated Environment Experience.** Working knowledge of GxP, 21 CFR Part 11, and validated-system constraints on data and AI deployments.* **Life Sciences Ontologies.** Familiarity with industry ontologies and standards (e.g., SNOMED CT, MedDRA, LOINC, RxNorm, CDISC, IDMP) and how they map into enterprise graph models.* **Graph Query Languages.** Hands-on experience with Cypher, SPARQL, Gremlin, GQL, or comparable graph query languages.* **LLM Integration with Graphs.** Experience with text-to-Cypher, text-to-SPARQL, or other LLM-driven graph query generation, and graph-augmented retrieval for AI systems.**Pay Range:**$216,400 - $324,600**Disclosure Statement:**The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.**Flex Designation:**Remote-Eligible**Flex Eligibility Status:**In this Remote-Eligible role, you can choose to be designated as: 1. **Remote**: work remotely five days per week and come into the office on occasion – you’re always welcome on-site; **or select** 2. **Hybrid**: work remotely up to two days per week; **or select** 3. **On-Site**: work five days per week on-site with ad hoc flexibility.Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.#LI-Remote**Company Information**Vertex is a global biotechnology company that invests in scientific innovation.Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.Any applicant requiring an accommodation in connection
- J-18808-Ljbffr Vertex Pharmaceuticals
Vacancy posted 3 days ago
Similar jobs that could be interesting for youBased on the Director, Knowledge Graph & Semantics - HYBRID ROLE in Boston, MA vacancy
$216.4k - $324.6k
Vertex Pharmaceuticals is seeking a Director of Knowledge Graph & Semantics for a hybrid role in Boston. This leader will oversee the development of the company's enterprise Knowledge Graph and Semantic Layer, essential for AI-driven insights across business domains. Key...Suggested$172k - $258k
Job Overview This hybrid position requires working from the Vertex office in Boston three... ...and services across the enterprise. The role secures AI throughout the full lifecycle—... ...both technical teams and senior leadership. Knowledge and Skills Cloud security architecture...SuggestedSummer workWork at officeRemote workFlexible hours2 days per week3 days per week$157.6k - $236.4k
Associate Director, Medical Writing Science General Summary: The Associate... ...effective leadership. This role provides guidance and... ...other departments. This is a hybrid role allowing 2 days per week... ...implements process improvements Knowledge and Skills: Demonstrated...SuggestedWork experience placementSummer workWork at officeRemote workRelocation packageFlexible hours2 days per week3 days per week- ...GmbH is seeking an Associate Director in People Operations & Transformation... ...service delivery model. The role involves establishing service... ...in Cambridge, MA, this hybrid position requires 7-10 years of HR experience and strong knowledge of ServiceNow. You'll benefit...Suggested
$155k - $190k
...and motivated Associate Director, Statistical... ...clinical programs. In this role, you will work with the... ...Macros, SAS/STAT, SAS/Graph, SAS/SQL, SAS/ODS and R... ...Experience and in-depth knowledge in CDISC including STDM... ...Shiny is a plus. * #LI-Hybrid The salary range below...SuggestedFull timeBeam Therapeutics Inc.
Cambridge, MA7 hours ago- ...Manager, People Experience to join their team. This role focuses on providing coaching and guidance to managers... ...-10 years of Human Resources experience and a strong knowledge of employment law. This position is hybrid, combining remote work with time spent in the office....Work at officeRemote work
- ...Employee Benefits Account Manager to join our Dedham, MA team. This hybrid role involves providing exemplary customer service for client... ...school diploma, an Insurance Producer license, strong technical knowledge, and proficiency with the MS Office Suite. The position...
- ...Higher Education, Inc. is seeking an Associate Director for Travel & Expense at Northeastern University in Boston. The role involves managing corporate card programs,... ...skills, and be proficient with SAP Concur. This hybrid position involves 3 days in the office per week...Work at office
- ...Associate Director - AI Scientist – Computational Radiology... ...Location: Boston, MA Hybrid: 3 days in office At... ...T team plays a crucial role in supporting AstraZeneca... ...with business domain knowledge, to develop and apply advanced... ..., clustering, graph theory, Monte‑Carlo sampling...Hourly payTemporary workWork at officeWorldwide
AstraZeneca
Boston, MA2 days ago - Vertex Pharmaceuticals is seeking an Associate Director, GMP Operational Quality in Boston to oversee team activities and... ...quality deliverables within department purview. The role requires comprehensive knowledge of quality assurance and compliance principles. You will...
- ...lead a high-performing team and ensure service excellence. This role involves coaching staff, maintaining client relationships, and managing... ...and strong communication skills. The position offers a hybrid work environment with a focus on continuous improvement and a people...Work at office
- Dormont Manufacturing Co is seeking an Associate Director, Statistics to join our team in Boston, MA. This role is essential for leading the integration of data science... ...future to patients. The position offers a hybrid work environment, competitive salary, and robust benefits...
$169.4k - $266.2k
Dormont Manufacturing Co is seeking a training specialist for Medical Affairs in Boston, MA. This hybrid role requires strong expertise in oncology and strategies for developing tailored training programs. You'll collaborate with teams to identify learning needs and ensure...$216k - $324k
Job Description The Senior Director, Manufacturing Technical Sciences... ...the assigned programs. The role will lead a team of process... ...operational requirements. This is a HYBRID role, requiring a minimum of... ...Leadership Team. Required Knowledge/Skills In-depth global...Summer workRemote workFlexible hours2 days per week3 days per week- SwiftCruit is seeking a People Analytics & Operations Leader located in Boston, MA. This hybrid role involves leading the HR Analytics team and ensuring strategic decision-making is driven by data insights. The successful candidate must have a strong background in HR metrics...
$109.24k - $182.32k
...experienced Sr. HR Manager to join our East Division in Boston, MA. This hybrid position involves leading HR initiatives and collaborating with... ...employee engagement and compliance with HR regulations. The role requires a minimum of 8 years of progressive HR experience,...- ...their GTM and Sales teams during a period of hyper growth. The role involves building a talent strategy, managing the hiring process... ...and equity. Preference for in-office presence 5 days a week, with hybrid working as an option. #J-18808-Ljbffr Harmonic Finance Inc ™ |...Work at office
$85k - $100k
...Human Resources Manager to lead HR operations and employee engagement strategies. This role involves managing full-cycle recruitment, performance management, and compliance across a hybrid workforce in Boston, MA. The ideal candidate will have 5-8 years of HR experience,...- ...biotechnology company is seeking an Associate Director, Digital Marketing to enhance engagement with healthcare professionals. The role involves developing omnichannel marketing... ...a solid understanding of analytics. This hybrid position offers competitive benefits and opportunities...
- ...Therapeutics, located in Needham, MA, is seeking an experienced Associate Director of Trial Master File Operations to oversee TMF activities across our oncology clinical programs. In this hybrid role, you will collaborate with multiple teams to ensure operational...
$195k - $215k
...receptor complexes, which play a crucial role in regulating receptor assembly and function... ...is seeking a highly motivated Associate Director to join its CMC (Chemistry, Manufacturing... ...San Diego or taking advantage of a more hybrid work schedule in Boston - we make the...Full timeWork at officeLocal areaImmediate start$160k - $200k
Sana Biotechnology, Inc. is seeking an Associate Director in Project Management to coordinate research, development, and manufacturing... ...in vivo CAR T cell engineering program in Cambridge, MA. This hybrid role requires a Bachelor's degree in life sciences or engineering...- ...in Boston is looking for a Modeling & Simulations Associate Director to lead M&S strategies in drug development. You will collaborate... ...in quantitative pharmacology and leadership skills. This hybrid-eligible role offers competitive compensation, including bonuses and...
- This role supports the Curlsmith brand within the Beauty & Wellness... ...for Curlsmith, Boston, MA, Hybrid (3 days onsite, 2 days remote)... ...communication tools (charts and graphs) for sales, management, and... ...packaging development/management. Knowledge of retail pricing, promotion,...Full timeTemporary workWork at officeLocal areaRemote work
- A prominent educational nonprofit is seeking a Director of Development for New England to lead major gifts fundraising. This hybrid role based in Boston requires over 10 years of experience in major gifts fundraising, exceptional relationship-building skills, and a deep...
- ...BI visualization tools. The ideal candidate will possess 8-10+ years of data analysis experience, proficiency in SQL, and excellent communication skills. The role offers a hybrid work model and a comprehensive compensation package. #J-18808-Ljbffr Mass General Brigham
- ...administer leaves, accommodations, and benefits programs. This role ensures compliance and supports nearly 5,000 employees across the... ...experience and excellent analytical and communication skills. The hybrid model allows for 3 days in the office and 2 days at home. #J-18...Work at office
- ...HR Business Partner to support their Sales & Service team. The role involves building relationships with employees, driving people solutions... ...or customer-facing environments. The position offers a hybrid work model and competitive compensation including equity options...
- ...Incorporated is seeking an experienced Associate Director, FP&A to lead financial direction and strategic insight for key functions. The role involves supporting pricing proposals,... .... The company offers competitive pay, a hybrid work model, and extensive employee...
$156k - $234k
Vertex Pharmaceuticals Inc (US) is looking for an Associate Director, FP&A to lead financial direction and strategic insights within the finance organization. This hybrid role allows for up to two remote workdays per week, focusing on financial governance and analytical...Remote work
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Director, Knowledge Graph & Semantics - HYBRID ROLE. Be the first to apply!
Related searches
- director of automation Boston, MA
- director lease administration Boston, MA
- director work from home Boston, MA
- director of process improvement Boston, MA
- director of culinary Boston, MA
- tennis director Boston, MA
- senior director Boston, MA
- director of administration Boston, MA
- nonprofit director Boston, MA
- director workforce management Boston, MA