Senior/Director, IT Operations and Governance

Crescent Biopharma’s vision is to build a world leading oncology company bringing the next wave of therapies for cancer patients. The Company’s clinical-stage pipeline includes its lead program, a PD-1 x VEGF bispecific antibody, as well as novel antibody-drug conjugates. By leveraging multiple modalities and established targets, Crescent aims to rapidly advance potentially transformative therapies as single agents and as part of combination regimens to treat a range of solid tumors. For more information, visit and follow the Company on LinkedIn and X.

We are seeking a Director/Senior Director to serve as the operational leader of the Information Technology function and be responsible for executing the company's technology strategy, roadmap, and governance framework. Reporting to the VP, Information Technology, you are responsible for translating the company's technology strategy into executable plans and ensuring successful delivery through internal resources, managed service providers, consultants, and business stakeholders.

You will oversee technology operations, project execution, governance, compliance, and vendor management while helping build scalable, audit-ready processes that support Crescent's growth and clinical development objectives. You will also serve as a key partner to business leaders across the organization and play an important role in advancing operational excellence, and cybersecurity maturity.

• Translate IT strategy and roadmap into actionable projects, workplans, and operational initiatives.
• Provide leadership and direction to internal IT personnel, contractors, and managed service providers.
• Oversee day-to-day IT operations and service delivery.
• Partner with business leaders across Clinical Development, Regulatory, Quality, Finance, Legal, HR, and other functions to prioritize technology initiatives and ensure successful delivery of business outcomes.
• Direct execution of technology initiatives across infrastructure, cybersecurity, collaboration platforms, business applications, and GxP systems.
• Manage project portfolios and ensure timely delivery of priorities, milestones, risks, and dependencies.
• Manage relationships with managed service providers, consultants, software vendors, and implementation partners.
• Coordinate internal stakeholders and external resources to ensure technology initiatives remain on schedule and within scope.
• Lead development, maintenance, and implementation of IT policies, standards, SOPs, and operational procedures.
• Support cybersecurity, privacy, and regulatory compliance initiatives including NIST CSF, GxP requirements, data protection regulations, and audit readiness activities.
• Maintain governance processes, documentation, and evidence required for inspections, audits, and due diligence reviews.
• Identify opportunities to improve processes, workflows, and operational maturity.
• Assist in workforce planning and resource allocation decisions.

• 10+ years of progressive information technology experience, including leadership responsibility for cross-functional initiatives, service providers, and technology teams.
• Experience in biotechnology, pharmaceutical, life sciences, or regulated healthcare environments.
• Demonstrated success managing external service providers and technology vendors.
• Experience developing and implementing IT governance frameworks, policies, and SOPs.
• Strong project and program management capabilities.
• Working knowledge of cybersecurity frameworks such as NIST CSF.
• Experience supporting regulated systems, computer system validation, audits, and compliance programs.
• Ability to communicate effectively with executive leadership and cross-functional stakeholders.
• Strong analytical, strategic thinking, and problem-solving skills.
• Ability to thrive in a fast-paced, ambiguous environment while managing competing priorities.
• Commitment to fostering a diverse and inclusive workplace.

• Opportunity to join a mission-driven team where you'll contribute to impactful work, take on varied responsibilities, and grow quickly in a dynamic environment
• Competitive compensation, including base salary, performance bonus, and equity
• 100% employer-paid benefits package
• Flexible PTO; also, two, one-week company-wide shutdowns each year
• A commitment to your professional development, with access to resources, mentorship, and growth opportunities

The salary range for this position is $220,000 to $260,000. The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography.

Additional Description for Pay Transparency:

The final salary offered will depend on several factors, which may include, but is not limited to relevant years of experience, educational background, and geography. Subject to the terms of their respective plans, employees and/or eligible dependents are eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability. Subject to the terms of their respective plans, employees are eligible to participate in the Company’s savings plan (401(k)). This position is eligible to participate in the Company’s long-term incentive program. Subject to the terms of their respective policies and date of hire, Employees are eligible for the following time off benefits: Vacation – Unlimited PTO; Sick time – 10 days per calendar year; Holiday pay, including two Company shut downs; Parental Leave – 16 weeks within one year of the birth/adoption/foster care of a child; FMLA; Military Leave. Additional information can be found -

Please note:

Crescent Biopharma is an Equal Opportunity Employer. We are committed to fostering a diverse, inclusive, and equitable workplace where all individuals are valued and respected. Employment decisions are based on qualifications, merit, and business needs, without regard to race, color, religion, gender, sexual orientation, national origin, disability, veteran status, or any other protected status.

Please note, Crescent does not accept unsolicited resumes from external agencies or recruiters. Submission of a resume without a prior written agreement does not create any express or implied contract between Crescent and the agency. Crescent will not pay any fees related to unsolicited resumes.

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