US Medical Head, COPD at Wilmington, Delaware

US Medical Head, COPD Biologics

At AstraZeneca, teams work across global boundaries to make an impact and find answers to complex challenges. This role sits at the heart of that mission, combining scientific depth with strategic leadership to advance care in chronic respiratory disease. As the US Medical Head, COPD Biologics, this position owns the medical strategy and execution for a novel Interleukin-33 targeting monoclonal antibody, crafting both product and disease area direction across the full lifecycle. Reporting directly to the VP Medical Respiratory, Immunology, Vaccines and Immune Therapies (R&I), this leader will guide a high-performing team, drive launches, and influence how evidence, access and clinical practice come together to transform outcomes for patients living with COPD and severe lower respiratory tract disease. Ready to steer a first-in-class biologic and redefine what's possible in respiratory medicine?

Accountabilities

• Lead and grow the COPD Biologics US medical team, setting clear vision, priorities and standards for excellence in disease area and brand strategy and execution.
• Develop and deliver coordinated medical strategies and plans for COPD Biologics and related indications, ensuring alignment with global medical, US commercial and market access partners.
• Develop and implement Transforming Healthcare initiatives that shape the biologics market in COPD Biologics, severe LRTD and adjacent areas, using evidence and insight to influence clinical practice and care pathways.
• Own disease area and brand medical budgets and resource planning, ensuring optimal allocation to high-impact activities across the lifecycle.
• Co-lead the COPD Biologics Core Value Team with Commercial and Market Access leaders, connecting strategy, science, access and execution to deliver a cohesive launch plan.
• Continuously assess and communicate the competitive landscape, translating insights into differentiated positioning and tactical plans.
• Act as the primary US medical point of contact for the Global Product Team (GPT), providing strategic input on lifecycle management, phase IV strategy and study design.
• Partner with evidence generation teams to define and execute real-world evidence programs that address US clinical, payer and policy needs.
• Build and sustain positive relationships with external authorities, professional societies, patient groups and key internal stakeholders to inform strategy and amplify scientific leadership.
• Serve as a medical spokesperson for COPD biologics in response to media inquiries when required, ensuring accurate, balanced and compliant communication.
• Coach, mentor and develop direct reports, actively leading succession, talent development and engagement within the team.
• Nurture a culture that values scientific rigor, teamwork, innovation and recognition, while maintaining full compliance with AstraZeneca policies and external regulations.

Essential Skills/Experience

• Sophisticated Scientific Degree (MBBS, PharmD, PhD, or MD) or equivalent education
• A Minimum of 7 years of experience in the pharmaceutical industry, ideally in Medical Affairs, working at the country and global/regional level
• Medical/clinical/scientific expertise in Respiratory Disease
• Experienced team leader, with a track record of establishing high performance teams
• Demonstrated track record delivering results in a sophisticated matrix environment, building capabilities, and leading impactful medical initiatives. Experience launching a new product
• US Regulatory Strategy Knowledge including product approval, label requirements/ negotiation
• Consistent track record to collaborate and build internal and external networks
• Strong intuition for business, with comprehensive understanding of the U.S. healthcare environment

Desirable Skills/Experience

• Leadership experience in US Medical Affairs for respiratory biologics or other specialty therapeutics.
• Direct involvement in major US product launches in COPD or related respiratory indications.
• Experience crafting or overseeing real-world evidence programs passionate about payer needs and healthcare system impact.
• Background working closely with field medical teams and external authorities to develop standards of care.
• Track record influencing cross-functional investment decisions using medical insights and data.

When we put unexpected teams in the same room, we unleash bold thinking with the power to inspire life-changing medicines. In-person working gives us the platform we need to connect, work at pace and challenge perceptions. That's why we work, on average, a minimum of three days per week from the office. But that doesn't mean we're not flexible. We balance the expectation of being in the office while respecting individual flexibility. Join us in our unique and ambitious world. AstraZeneca offers an environment where medical leaders sit at the intersection of science and real-world practice, using evidence to influence how care is delivered today and tomorrow. Work alongside experts who embrace change because it sparks innovation, from bold real-world studies to pioneering launches that shift treatment paradigms in respiratory disease. Collaboration across research, medical and commercial functions is embedded in how things get done here, opening doors to new ideas, broader networks and continuous development without borders. Every study designed, every partnership built and every insight translated into practice contributes directly to better outcomes for patients and fuels the next wave of scientific progress. If this opportunity to lead COPD medical strategy in the US excites you, apply now and take the next step in your career with AstraZeneca.