Postdoctoral Researcher - Neural Circuit Regulation of Immune Function

The BioMed X Institute in New Haven, Connecticut, USA is establishing a new, fully funded research group in the following field: Neural Circuit Regulation of Immune Function If you hold a PhD or master's degree with an outstanding track record or strong interest in this field, we invite you to apply with a project proposal for a position in our new research group (1 group leader, 2 postdoctoral researchers, 2 research assistants). Each BioMed X project team is sponsored by an industry partner. The sponsor of this call for application is Biogen . Bidirectional communication between the central nervous system (CNS) and the immune system critically shapes autoimmune and inflammatory disease trajectories. While recent studies have identified neural circuits, neurotransmitters, and glial pathways influencing immune function, mechanistic dissection remains constrained by fragmented models and low-throughput readouts. Existing approaches rarely allow systematic, causal perturbation of defined CNS pathways with quantitative immune readouts, limiting target discovery and translational relevance. Our goal is to uncover neural circuits that modulate immune system function and discover novel, actionable molecular targets to benefit patients living with autoimmune diseases. The primary objective of this project is to establish scalable, perturbation-driven platforms that enable controlled perturbation of CNS pathways with simultaneous, quantitative immune readouts. A particular focus is encouraged on brainstem-mediated neuroimmune regulation , particularly circuits involving the Nucleus Tractus Solitarius (NTS) as a central integrator of peripheral signals and autonomic outputs. Targeting such defined nodes may enable precise and physiologically relevant immune modulation . Proposals should integrate neurobiology, immunology, and advanced experimental technologies to uncover actionable modulators of the CNS-immune axis, with strong emphasis on causal biology and translational impact . In addition, proposals should incorporate an in-silico modeling component that integrates data across in-vivo, in vitro, and ex vivo perturbation experiments to: Identify emergent pathways and regulatory networks Prioritize targets for validation Enable predictive modeling of neuroimmune interactions Accelerate decision-making and scalability To maximize impact, proposals are encouraged to anchor their approach to autoimmune disease indications with high unmet patient need , with a clear therapeutic hypothesis, differentiation from existing therapeutic strategies, and a path to translation. Research Deliverables Research proposals should focus on the following key deliverables: Development of a scalable in vitro or ex vivo platform enabling targeted CNS pathway perturbation (including defined circuits such as NTS-related pathways ) with multiplexed immune readouts. Integration of in-silico modeling frameworks that combine multi-modal experimental data to identify and prioritize key neuroimmune targets and pathways. Identification and mechanistic validation of novel neural or glial modulators influencing immune activation, tolerance, and/or autoimmunity. Demonstration of platform utility for systematic screening of genetic, molecular, and/or biologic modulators of the CNS–immune axis. Establishment of a translational link to a high-impact autoimmune disease indication , including rationale for clinical relevance and potential development path. Original ideas reaching far beyond the current state-of-the-art are particularly encouraged, especially those enabling first-in-class target discovery. Purely descriptive studies or approaches lacking a perturbation-driven, scalable platform will not be prioritized. What we offer A position in a fully funded research group with an annual budget of 1.58 million USD . The funding package covers salaries, materials, services, travel, overhead, as well as access to the core facilities on the campus of Yale University . A project term of 3-5 years . An exciting research opportunity in a multidisciplinary and international research community with a collegial and flexible working environment. Continuous coaching by key opinion leaders from top academic institutions and experienced researchers from the pharma industry. Participation in the BioMed X boot camp: Here you will learn how to build a compelling pitch presentation in only 5 days. There is flexibility over starting dates, but successful applicants are welcome to take up post in New Haven starting January 1, 2027 . Candidates for postdoctoral positions are expected to have completed a PhD (or equivalent) within the last three years and a certain degree of specialization in one or more relevant cutting-edge technologies. #J-18808-Ljbffr BioMed X