R&D Senior Scientist

Job Description

Job Description

About Us

Sino Biological is an internationally recognized reagent supplier and contract research organization, listed on ChiNext of the Shenzhen stock exchange (301047 Sino Biological Inc.). Sino Biological's core technology platform is its in-house developed mammalian cell-based recombinant expression system, which employs proprietary reagents and processes for the efficient production of antigens and antibodies.

With its main manufacturing facilities in Beijing, China, Sino Biological also has a growing global presence with a US headquarters in the greater Philadelphia area, a bioprocessing facility in Houston, Texas, and subsidiaries in Frankfurt, Germany, and Tokyo, Japan.

As part of its major global expansion, the company has established the Center for Bioprocessing (C4B) in Houston, Texas, located in the world-renowned Texas Medical Center at Levit Green. This vibrant hub is home to some of the most cutting-edge innovation in biotechnology, offering our team an inspiring environment to do meaningful, impactful work in the heart of the medical and research community.

Job Description

We are seeking an accomplished scientist with industrial experience in recombinant protein and antibody production to join our team as a Senior or Principal R&D Scientist. This role requires strong expertise in sequence and construct design, expression, purification, and characterization of complex biomolecules, including engineered antibody formats (full-length IgG, bispecific, Fab, scFv, Fc-fusions) and fusion proteins. The successful candidate will lead small - to medium - scale production projects, serve as a technical authority in molecular and biochemical design, and ensure delivery of high- quality proteins for research and therapeutic applications. While the emphasis is on project leadership, planning, and mentorship, this position also involves hands-on bench work when needed to support critical projects or troubleshooting.

Flexibility is required, including potential weekend work and early or late weekday shifts based on project demands.

Responsibilities

• Lead end-to-end protein production projects, from amino acid sequence design to purified, quality-tested product.
• Design and optimize molecular constructs for recombinant proteins, including antibodies and antibody-derived formats (full-length IgG, bispecific, Fab, scFv, Fc-fusions) as well as Fc- and non-Fc fusion proteins.
• Develop and lead critical SOPs, especially those related to sequence/construct design and molecular engineering, in coordination with upstream, downstream, and analytical teams.
• Assist with customized project inquiry review. Determine feasibility of protein expressions, identify areas for optimization, and draft production proposals for project managers.
• Advise and review upstream expression workflows in mammalian and insect systems (HEK293, CHO, Sf9), ensuring reproducibility and scalability.
• Lead downstream purification strategies using modern chromatography platforms (affinity, IEX, SEC) and contribute to process optimization.
• Develop and interpret analytical assays, including ELISA, BLI, DSF, HPLC-SEC, and related QC methods, to assess protein quality, stability, and activity.
• Mentor and supervise associates and junior scientists, ensuring rigorous documentation, data integrity, and efficient lab execution.
• Collaborate across departments to align on construct design principles, process strategies, and project execution.
• Perform bench work when necessary to support critical experiments, troubleshooting, or method development.

Requirements

• Ph.D. in Biochemistry, Molecular Biology, Biotechnology, or related field, with 5+ years of industrial experience in recombinant protein and antibody production.
• Proven expertise in amino acid sequence design and molecular construct development for recombinant proteins, including antibodies (full-length IgG, bispecific, Fab, scFv) and fusion proteins (Fc- and non-Fc).
• Experience with protein structural and sequence analysis software.
• Demonstrated ability to act as a sole technical contributor and project owner.
• Hands-on experience with mammalian and insect cell expression systems, as well as chromatography purification (e.g., Cytiva AKTA).
• Proficiency in protein characterization assays such as ELISA, BLI, DSF, HPLC-SEC, and SDS-PAGE.
• Strong record of SOP authorship and cross-team collaboration on technical standards.
• Excellent project management, organizational, and communication skills.
• Industrial CRO/CMO experience preferred.
• Flexibility to work occasional early/late shifts or weekends based on project needs.
• Must be able to lift and move 25–50 lbs as needed.
• At this time, we are unable to provide visa sponsorship. Applicants must be legally authorized to work in the United States now and in the future without the need for sponsorship.

Why Join Us at C4B?

Working at Sino Biological’s C4B facility isn’t just another lab job — it’s a chance to be part of something bigger. Here are just a few of the unique benefits of our Houston site:

• World-class location: Be part of the Texas Medical Center, the largest medical complex in the world, where biotech innovation thrives.

• Beautiful work environment: Enjoy a brand-new, state-of-the-art facility designed for collaboration and scientific excellence.

• Free onsite parking: Skip the hassle and expense of parking in the Medical Center — we’ve got you covered.

• Free onsite gym: Stay active and energized with convenient access to fitness facilities right at work.

• Career growth opportunities: Learn directly from industry professionals while growing your career at a global biotech company.

• Supportive team culture: A welcoming, team-first workplace that values diversity, collaboration, and professional development.

Note:

Only shortlisted candidates will be contacted for interviews. If selected, an HR team member will reach out to schedule a quick phone interview using the contact information provided in your resume.

Sino Biological Inc. is an equal-opportunity employer. We celebrate diversity and are committed to building an inclusive environment for all employees.

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