DMPK Scientist: PK/PD Modeling for RNA Therapies
Alnylam Pharmaceuticals, Inc.
Alnylam Pharmaceuticals, Inc. in Cambridge, MA is seeking a DMPK Scientist to design and interpret in vitro and in vivo ADME and PK/PD studies for siRNA and other modalities, informing human dose projections and candidate selection. You will build quantitative models and simulations using Phoenix WinNonlin, Monolix, and R, integrate PK/PD and biomarker data, collaborate with cross-functional teams, and prepare analyses and regulatory submissions. #J-18808-Ljbffr Alnylam Pharmaceuticals, Inc.
- Alnylam Pharmaceuticals in Cambridge, MA seeks a DMPK Scientist to design and interpret ADME and PK/PD studies for siRNA and other modalities, applying quantitative pharmacology to guide candidate selection and human dose predictions. The role demands expertise in non-compartmental...Suggested
- Hemab is seeking a Scientist, PK/PD Modeling & Simulation in Cambridge, MA to develop population PK/PD, PBPK and QSP models to support dose selection and trial design. You will collaborate with clinical pharmacology, nonclinical, and regulatory teams to inform clinical...Suggested
$176.2k - $277.3k
...and collaborative Principal Scientist (director-level equivalent) to... ...metabolism and pharmacokinetic (DMPK) efforts across multiple... ...generation and interpretation of PK and PK/PD data sets and through... ...pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin, Berkeley...SuggestedFull timeFor contractorsLocal areaWorldwideRelocationVisa sponsorshipFlexible hoursShift work$108.5k - $201.5k
...enthusiastic and motivated PK Sciences project... ..., radioligand therapies and/or cell therapies... ...(ADME, BA), Modeling & Simulation (M&S),... ...understanding of PK/PD relationships and develop... ...overseeing ADME/DMPK project strategy, either... ...for Principal Scientist II • Extensive...Suggested$110.4k - $165.6k
...metabolism, and excretion) and PK/PD (pharmacokinetics/... ...quantitative pharmacology and modeling, consequently guiding candidate... ...interact with highly motivated scientists across a broad array of disciplinary... ...Key Responsibilities Support DMPK strategy across drug...SuggestedFull timeTemporary workLocal areaFlexible hours$129.64k - $157.1k
...breakthroughs in cell therapy, this is work that... ...and Seattle, scientists focus on novel targets... ...in vivo and ex-vivo models of Cancer biology and... ...in vitro PD markers and assay development... ...e.g. pharmacology, DMPK, informatics and... ...processing of DNA/RNA/protein. Experience...Hourly payFull timeTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work$100k - $120k
...StealthCo - Associate Scientist, In Vitro... ...into transformative therapies and get them quickly... ...translatability from animal models to humans, which... ...engagement and PD effect across delivery... ...studies (including RNA and protein extraction... ...data anchoring PK/PD interpretation In...Shift work$179k - $236k
...Scientific Officer, this role leads DMPK and bioanalytical strategy... ...DMPK and bioanalytical scientist with experience in PK study design, bioanalytical... ...biomarker, and translational PD readoutsLead method... ...medicine, or nucleic acid / RNA therapeuticsFamiliarity with...$126k - $234k
...In Vivo Scientist This position is located in Cambridge, MA and... ...approaches including targeted therapies, immunotherapies, CAR-T, and... ...development and application of in vivo models for evaluating novel cancer... ...vivo anti-tumor efficacy and PK/PD studies aimed at evaluating...Remote work- Mass General Brigham is seeking a PhD-level scientist to advance RNA and lipid nanoparticle manufacturing within the Gene and Cell Therapy Institute. You will translate benchtop processes into automated formats, develop robust unit operations, and collaborate with cross...
- Korro Bio in Cambridge, MA, is seeking a Scientist I to advance cell biology and RNA-based therapeutics. You will design and execute... ...cell-based assays, establish hepatocyte models, and work closely with in vivo pharmacology and DMPK teams to drive pharmacodynamic...
- Noara Therapeutics, Cambridge, MA, is seeking a Senior Scientist or Scientist with deep expertise in cell biology, immunology, and assay development... ..., computational biology, automation, and data science teams to develop scalable assays for our RNA‑LNP #J-18808-Ljbffr C10 Labs
$147.2k - $220.8k
...pharmacokinetic/pharmacodynamic (PK/PD) relationships of... ...and Development as a Principal Scientist within Drug Metabolism and Pharmacokinetics (DMPK), providing scientific leadership... ...quantitative approaches, including modeling and simulation, to support dose...Full timeTemporary workWork at officeLocal areaFlexible hours$157k - $213k
...broad potential of RNA medicines to transform... ...detail-oriented Scientist with strong expertise... ...Pharmacokinetics (DMPK) sciences to... ...interpreting pharmacokinetic (PK), toxicokinetic (TK... ...i.e., ADME, PK, PK/PD) to support... ...on experience with modeling and simulation is a...Temporary workSummer workWork at officeLocal area$119.7k - $222.3k
...enthusiastic and motivated PK Sciences... ...conjugates, radioligand therapies and/or cell... ...Disposition (ADME, BA), Modeling & Simulation (M&S),... ...nonclinical and clinical PK/PD relationships and... ...overseeing ADME/DMPK project strategy in... ...for Principal Scientist II. 4+ years of experience...Full time$150k - $170k
...the development of unique cell therapies with significantly streamlined... ...is seeking a highly motivated Scientist or Senior Scientist to join our Process Development (PD) team. This role focuses on iPSC... ...preparation for bulk and single cell RNA-seq). Conduct genome integrity...Contract workLocal area- ...therapeutics company that is developing a new class of engineered RNA therapeutics. The Job We are seeking an experienced RNA... ...RNA therapeutics and lipid nanoparticles. Experience with mouse models of oncology. Benefits Competitive salary commensurate with experience...Flexible hours
- ...is seeking a passionate and dedicated In Vitro Disease Modeling and Functional Genomics Scientist. The candidate will work directly on the client site in... ...Expertise in molecular biology techniques, including RNA extraction, qPCR, ELISA/MSD, and ICC. Experience with...Full timeContract workMonday to Friday
$142.4k - $224.1k
...& Development. We are seeking an Associate Principal Scientist to join our Process Modeling & Analytics team within the Development Sciences and Clinical... .... Experience with high-throughput chromatography (HT-PD) or PAT data streams and their integration into model...Full timeFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work$105k - $127k
...latest breakthroughs in cell therapy, this is work that transforms... ...are seeking a Senior Associate Scientist with strong in vivo skills, experience... ...Performing and analyzing PK/PD readouts, such as ELISA, LC-MS... ...be eligible for a hybrid work model with at least 50% onsite at...Hourly payFull timeContract workTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work$203.71k - $305.56k
...Are you an experienced clinical scientist who wants to help bring transformative cell and immunotherapies... ...readouts across safety, efficacy, PK/PD, biomarkers, and operations, with options... ...in the MS, neuroimmunology, and cell-therapy literature and competitive landscape, and...Hourly payTemporary workInterim role- ...Research Scientist Position at Basis Research scientists lead Basis' efforts to develop a deeper understanding of the conceptual, mathematical... ...increasing recognition that both having and discovering world models are central to intelligence, current AI systems struggle to...Full timeWork at officeImmediate start
- ...Research Scientist A Few Words About Us Integrated Resources, Inc is a premier staffing... ...(IT), Clinical Research, Rehabilitation Therapy and Nursing. Job Description We are... ...biology, biochemistry, structural modeling and antibody engineering skills The candidate...
$170k - $200k
...stability, permeability, and ADME/PK properties; and using... ...able to integrate computational modeling, structural information, biophysical... ..., structural biology, DMPK and biology design molecules to... ...talented and passionate team of scientists Be a part of a cutting-edge...- ...platform includes Beacon-1 ADMET prediction models, human dose projection tools, and Indy, an... ...1 ADME panels that enable initial human PK projection, closing the loop from computational... .... Alongside outstanding compchem, DMPK, and machine learning colleagues, bring Inductive...
$112k - $168k
...are seeking a Computational Genomics Research Scientist to support the development of transformative cell and gene therapies across Vertex's research portfolio. This Boston... ...diverse genomic datasets, including bulk RNA-seq, single-cell profiling, spatial transcriptomics...Full timeSummer workRemote workFlexible hours2 days per week3 days per week- ...highly motivated and innovative Senior Scientist II to join the Rheumatology team at the... ...and hands-on knowledge of in vivo disease models. Success in this role requires the... ...drug candidates, including establishing PK/PD relationships, developing, and optimizing...Full timeLocal areaImmediate start
- ..., X and YouTube. Job Description Scientist I, In Vivo Pharmacology Job Description... ...target identification, validation, PK/PD and efficacy studies. The ideal candidate... ...pharmacology teams ~ Experience with in vivo models of neurodegeneration, particularly with...Full timeTemporary workLocal area
$93.6k - $156k
...innovative technologies into impactful therapies and vaccines. In this role, you will be... ...Cardiovascular Discovery Biology team, the Senior Scientist will play a pivotal role in the drug... ...the-art cellular, molecular, and animal model techniques to investigate mechanisms of...Permanent employmentFull timeH1bLocal areaVisa sponsorshipWork visaRelocation package$150k - $170k
...immune system to develop transformative therapies for cancer and autoimmune disease. Using... ...Immune Medicines is seeking a Deep Learning Scientist II to join the Artificial Immune... ...learning approaches spanning protein language models, structural modeling, and multi-modal...Full timeTemporary workWork experience placementFlexible hours
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