DMPK Scientist: PK/PD Modeling for RNA Therapies
Alnylam Pharmaceuticals, Inc.
Alnylam Pharmaceuticals, Inc. in Cambridge, MA is seeking a DMPK Scientist to design and interpret in vitro and in vivo ADME and PK/PD studies for siRNA and other modalities, informing human dose projections and candidate selection. You will build quantitative models and simulations using Phoenix WinNonlin, Monolix, and R, integrate PK/PD and biomarker data, collaborate with cross-functional teams, and prepare analyses and regulatory submissions. #J-18808-Ljbffr Alnylam Pharmaceuticals, Inc.
- ...quality biotherapeutics development go hand in hand. As a Scientist, PK/PD Modeling & Simulation, you will be responsible for developing, validating... ...and advancing our mission to deliver first-in-class therapies to patients with rare bleeding disorders. At Hemab, we foster...Suggested
- Alnylam Pharmaceuticals in Cambridge, MA seeks a DMPK Scientist to design and interpret ADME and PK/PD studies for siRNA and other modalities, applying quantitative pharmacology to guide candidate selection and human dose predictions. The role demands expertise in non-compartmental...Suggested
- ...is seeking a highly motivated Scientist with expertise in bioanalytical and DMPK sciences to support RNA‑based drug programs from preclinical... ...designing and interpreting PK/TK studies across cross‑functional... ...industry experience, strong PK/PD knowledge, and experience with...Suggested
- Hemab is seeking a Scientist, PK/PD Modeling & Simulation in Cambridge, MA to develop population PK/PD, PBPK and QSP models to support dose selection and trial design. You will collaborate with clinical pharmacology, nonclinical, and regulatory teams to inform clinical...Suggested
$129k - $203.1k
...Bioanalytics (PDMB) is seeking a curious and collaborative Senior Scientist for our growing Translational PK/PD organization. The Translational PK/PD Senior Scientist is a skilled mathematical modeler and scientist who designs and executes analyses, with supervision,...SuggestedFull timeFor contractorsLocal areaFlexible hours$126k - $234k
...Internal Title: Principal Scientist II or Senior Principal... ...diverse pipeline of innovative therapies. We are seeking a translational modeler eager to accelerate... ...QSP) and mechanistic PBPK/PD approaches to inform key... ...apply mechanistic models (PK/PD, QSP, and PBPK/PD) that...Full time- ...Bioanalytics (PDMB) is seeking a curious and collaborative Senior Scientist for our growing Translational PK/PD organization. The Translational PK/PD Senior Scientist is a skilled mathematical modeler and scientist who designs and executes analyses, with supervision,...Full time
- Merck & Co., Inc. in the United States is seeking a Senior Scientist for Translational PK/PD within the PDMB group. The role focuses on modeling biologics, protein therapeutics, and peptides to guide drug discovery strategy. You will integrate diverse data types, build...
$157k - $213k
...broad potential of RNA medicines to transform... ...detail-oriented Scientist with strong expertise... ...Pharmacokinetics (DMPK) sciences to... ...interpreting pharmacokinetic (PK), toxicokinetic (TK... ...i.e., ADME, PK, PK/PD) to support... ...on experience with modeling and simulation is a...Temporary workSummer workWork at officeLocal area$176.2k - $277.3k
...and collaborative Principal Scientist (director-level equivalent) to... ...metabolism and pharmacokinetic (DMPK) efforts across multiple... ...generation and interpretation of PK and PK/PD data sets and through... ...pharmacokinetic (PBPK) software modeling (e.g., Phoenix WinNonlin, Berkeley...Full timeFor contractorsLocal areaWorldwideFlexible hours- OverviewThe mission of DMPK is to enable efficient and successful... ..., and excretion) and PK/PD (pharmacokinetics/pharmacodynamics... ...quantitative pharmacology and modeling, consequently guiding candidate... ...with highly motivated scientists across a broad array of disciplinary...Full timeTemporary workLocal areaFlexible hours
$179k - $236k
...Scientific Officer, this role leads DMPK and bioanalytical strategy... ...DMPK and bioanalytical scientist with experience in PK study design, bioanalytical... ...biomarker, and translational PD readoutsLead method... ...medicine, or nucleic acid / RNA therapeuticsFamiliarity with...$108.5k - $201.5k
...enthusiastic and motivated PK Sciences project... ..., radioligand therapies and/or cell therapies... ...(ADME, BA), Modeling & Simulation (M&S),... ...understanding of PK/PD relationships and develop... ...overseeing ADME/DMPK project strategy, either... ...for Principal Scientist II • Extensive...- ...marketed small molecule therapies and supported by top-tier... ...We are seeking a Senior Scientist, DMPK, to join our R&D group and... ...audiences. Propose ADME/PK, biodistribution and PK-PD approaches at team... ...to optimize preclinical models and inform on first in human...Flexible hours
$120 - $140 per hour
...provider in pharmaceutical research is seeking a Senior Scientist to act as a DMPK project representative. The role involves providing scientific... ...will have extensive experience in ADME principles and PK/PD modeling, strong communication skills, and the ability to work...Hourly payContract work$105.04k - $127.29k
## Senior Associate Scientist, In Vivo Pharmacology, Oncology... ...breakthroughs in cell therapy, this is work that... ...vitro, in vivo and ex-vivo models of Cancer biology and... .../antibody development, DMPK and translational group... ...in vivo efficacy and PK/PD studies and experiments...Hourly payFull timeTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work$126k - $234k
...is accessible to you.Over 40 therapies in the clinic! NIBR Oncology... .... NIBR is seeking an in vivo scientist to join our Oncology Pharmacology... ...and application of in vivo models for evaluating novel cancer... ...vivo anti-tumor efficacy and PK/PD studies aimed at evaluating drug...Full timeRemote work$127k - $141k
...delivering the next generation of gene editing therapies to patients. The Company is leveraging... ...is seeking a talented, highly motivated Scientist I with expertise in oligonucleotide... ...will have hands-on experience in long guide RNA synthesis, chemical deprotection, purification...Full timeTemporary workFor contractors$58k - $123.2k
...highly motivated Postdoctoral Scientist to join the Drug Delivery and... ...a primary focus on CNS gene therapy biodistribution and molecular... ...pharmacokinetics and pharmacodynamics (PK/PD) to inform dose selection,... ...in higher vertebrate CNS models. Provide scientific...Full timeFixed term contractH1bVisa sponsorshipWork visaFlexible hours- Merck in Boston, MA is seeking a Translational PK/PD Senior Scientist to design and execute modeling analyses that guide drug discovery for biologics, proteins and peptides. You will serve as a PK/PD modeler in cross-functional teams and help shape dose predictions and...
$150k - $170k
...breakthroughs into transformative therapies and get them quickly, safely... ...most. Raven’s experienced scientists, operators, and healthcare... ...and IgE Design and coordinate PK/PD studies to run externally, and... ...in vitro and in vivo models of atopic disease Experience...- Scholar Rock is seeking a motivated scientist to join the R&D team, focusing on bioanalytical assay development to evaluate novel therapeutic antibodies. You will establish PK, immunogenicity and biomarker assays across discovery, preclinical and clinical stages, contributing...
- Noara Therapeutics, Cambridge, MA, is seeking a Senior Scientist or Scientist with deep expertise in cell biology, immunology, and assay development... ..., computational biology, automation, and data science teams to develop scalable assays for our RNA‑LNP #J-18808-Ljbffr C10 Labs
$105.04k - $127.29k
...latest breakthroughs in cell therapy, this is work that transforms... ...are seeking a Senior Associate Scientist with strong in vivo skills, experience... ...Performing and analyzing PK/PD readouts, such as ELISA, LC-MS... ...be eligible for a hybrid work model with at least 50% onsite at...Hourly payFull timeContract workTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work- ...Institutes for BioMedical Research, Inc. in Cambridge (USA) is seeking a Research Scientist I or II in Oligonucleotide Chemistry to join a fast-paced team developing RNA-based therapies. You will synthesize research-scale oligonucleotides, purify and characterize them,...
$120k - $170k
...breakthroughs into transformative therapies and get them quickly, safely... ...most. Raven’s experienced scientists, operators, and healthcare... ...translatability from animal models to humans, which provides a potentially... ...conjugates to optimize PK/PD properties. Assist in...- ...using its proprietary RNA editing platform. Korro... ...motivated Senior Associate Scientist to join our In Vivo... ...oligonucleotides in rodent models across a range of... ...pharmacokinetic/pharmacodynamic (PK/PD) relationships.... ...Translational Biology, and DMPK teams to support...Work at officeFlexible hours
$120k - $170k
Raven StealthCo- Scientist, Conjugation Chemistry About Raven: We are... ...into transformative therapies and get them quickly, safely... ...translatability from animal models to humans, which provides a potentially... ...oligonucleotide conjugates to optimize PK/PD properties Assist in...Flexible hours$131k - $146k
...next generation of gene editing therapies to patients. The Company is... ...driven, discovery-minded Scientist to join our Platform Technology... ...Molecular Biology, Biochemistry, RNA Biology, Chemical Biology, or... ...systems into in vivo animal models, using non-viral (e.g., LNP)...Full timeTemporary work$58k - $123.2k
...peptides, antibodies, genetic medicines, RNA therapeutics, and more. Our global... ...group deploys a powerful suite of model‑based approaches—including PBPK, PK/PD, QSP, and pharmacometrics to shape... ..., and collaborative postdoctoral scientist to join the Global PKPD group...Full timeTemporary workH1bVisa sponsorshipWork visaFlexible hours
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