DMPK Scientist - PK/PD Modeling & ADME Strategy
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals in Cambridge, MA seeks a DMPK Scientist to design and interpret ADME and PK/PD studies for siRNA and other modalities, applying quantitative pharmacology to guide candidate selection and human dose predictions. The role demands expertise in non-compartmental and compartmental analysis, PBPK, and systems pharmacology, with strong communication and teamwork within a fast-paced environment. #J-18808-Ljbffr Alnylam Pharmaceuticals
- ...quality biotherapeutics development go hand in hand. As a Scientist, PK/PD Modeling & Simulation, you will be responsible for developing, validating... ...will be central to integrating modeling and simulation strategies into Hemab’s clinical programs and advancing our mission...Suggested
- Hemab is seeking a Scientist, PK/PD Modeling & Simulation in Cambridge, MA to develop population PK/PD, PBPK and QSP models to support dose selection... ..., and regulatory teams to inform clinical development strategies and regulatory filings, while contributing to model-...Suggested
$129k - $203.1k
...curious and collaborative Senior Scientist for our growing Translational PK/PD organization. The Translational PK... ...Scientist is a skilled mathematical modeler and scientist who designs and... ...supervision, guiding drug discovery strategy with a focus on biologics, protein...SuggestedFull timeFor contractorsLocal areaFlexible hours- OverviewThe mission of DMPK is to enable... ...and interpreting ADME (absorption, distribution... ...excretion) and PK/PD (pharmacokinetics/... ...pharmacology and modeling, consequently... ...highly motivated scientists across a broad array... ...ResponsibilitiesSupport DMPK strategy across drug...SuggestedFull timeTemporary workLocal areaFlexible hours
$176.2k - $277.3k
...collaborative Principal Scientist (director-level... ...pharmacokinetic (DMPK) efforts across... ...interpretation of PK and PK/PD data sets and through... ...vitro and in vivo ADME and... ...safetyContribute to global DMPK strategy through close... ...pharmacokinetic (PBPK) software modeling (e.g., Phoenix...SuggestedFull timeFor contractorsLocal areaWorldwideFlexible hours- ...curious and collaborative Senior Scientist for our growing Translational PK/PD organization. The Translational PK... ...Scientist is a skilled mathematical modeler and scientist who designs and... ...supervision, guiding drug discovery strategy with a focus on biologics, protein...Full time
- ...We are seeking a Senior Scientist, DMPK, to join our R&D group and... ...external audiences. Propose ADME/PK, biodistribution and PK-PD approaches at team... ...group to optimize preclinical models and inform on first in human clinical dosing strategies. Review preclinical study...Flexible hours
$108.5k - $201.5k
...enthusiastic and motivated PK Sciences project... ...pharmacology strategies to support the... ...Drug Disposition (ADME, BA), Modeling & Simulation (M&S)... ...understanding of PK/PD relationships and... ...role overseeing ADME/DMPK project strategy,... ...for Principal Scientist II • Extensive...$157k - $213k
...motivated and detail-oriented Scientist with strong expertise... ...and Pharmacokinetics (DMPK) sciences to support... ...pharmacokinetic (PK), toxicokinetic (TK),... ...in vivo studies (i.e., ADME, PK, PK/PD) to support advancement... ...-on experience with modeling and simulation is a plusPay...Temporary workSummer workWork at officeLocal area$120 - $140 per hour
...provider in pharmaceutical research is seeking a Senior Scientist to act as a DMPK project representative. The role involves providing... ...ideal candidate will have extensive experience in ADME principles and PK/PD modeling, strong communication skills, and the ability to...Hourly payContract work$89.6k - $166.4k
...CambridgeInternal Title: Senior Scientist ISupport discovery and... ..., and execution of in-vitro ADME assays, while building next... ...and permeability to support PK Science’s strategies.Interpret in vitro ADME data... ...years; MSc: 4+ years of ADME/DMPK experience.Experience working...Full time$126k - $234k
...Internal Title: Principal Scientist II or Senior Principal... ...a translational modeler eager to accelerate oligonucleotide... ...that shape program strategies. As part of a truly... ...) and mechanistic PBPK/PD approaches to inform key... ...apply mechanistic models (PK/PD, QSP, and PBPK/PD)...Full time$179k - $236k
...Scientific Officer, this role leads DMPK and bioanalytical strategy across nonclinical and clinical... ...DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method... ...PK, biomarker, and translational PD readoutsLead method development,...- ...predictive and generative AI models that accelerate... ...implementing translational strategies, advancing our oncology... ...in vivo pharmacology, PK/PD, and safety assessments... ...efficacy data. DMPK and Toxicology: To align... ...in vivo efficacy with ADME and exposure data, informing...Contract workWork at office3 days per week
- ...Position The Senior Scientist, DMPK will provide... ...candidates by integrating DMPK strategy across multiple therapeutic... ...experimental and modeling approaches to de risk... ...pharmacokinetic/pharmacodynamic (PK/PD) modeling and/or... ...global Novo Nordisk ADME experts to harmonize...Local areaFlexible hours
- Scholar Rock is seeking a motivated scientist with bioanalytical assay development experience to join our R&D team. This role will establish PK, immunogenicity, and biomarker assays to evaluate novel therapeutic antibodies across discovery, preclinical, and clinical stages...
- Scholar Rock is seeking a motivated scientist to join the R&D team, focusing on bioanalytical assay development to evaluate novel therapeutic antibodies. You will establish PK, immunogenicity and biomarker assays across discovery, preclinical and clinical stages, contributing...
- ...motivated Senior Associate Scientist to join our In Vivo... ...oligonucleotides in rodent models across a range of... ...vivo pharmacology, and ADME (absorption, distribution... ...pharmacokinetic/pharmacodynamic (PK/PD) relationships.... ...Biology, and DMPK teams to support exposure...Work at officeFlexible hours
$115k - $209k
...companies. As part of Flagship’s integrated model of science, entrepreneurship, and... ...Position Summary We are seeking a Principal Scientist to join Pioneering Intelligence (PI), a... ...house expert in clinical and commercial strategy, and will lead the codification of therapeutic...Casual work$231.9k - $365k
...opportunity for a Distinguished Scientist with deep experience spanning... ...to shape QB and network-wide strategy, guide project teams, and... ...pointsGuide fit-for-purpose assay and model strategies that streamline... ..., and in vivo pharmacology, PK/PD, IVIVC, and translational...Full timeFor contractorsLocal areaImmediate startFlexible hours$98.7k - $183.3k
...Onsite (Lab Based)Internal Title: Senior Scientist IILocation: CambridgeThis role is based in... ...bioanalytical support investigating the PK/TK properties of low molecular weight and... ...experiments/workflows that implement project strategy.Analyzes, writes reports and communicates...Full timeLocal areaShift work$146k - $236k
...portfolio of AI-first companies. As part of Flagship’s integrated model of science, entrepreneurship, and capital, it transforms... ...impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World...- ...motivated and accomplished scientist to lead the Bioanalytical (BioA) and PK/PD function. This role is... ...pharmacokinetic modeling to translate data into actionable... ...Bioanalytical and PK/PD strategies for ADC programs,... ...Oversee in vitro and in vivo ADME studies, including payload...
$178.5k - $257.83k
Job title: Distinguished Scientist, Transgenic Model and TechnologyLocation: Cambridge, MAAbout the jobThe Translational In Vivo Models (TIM)... ...technology to devise and execute sophisticated experimental strategies for target validation, proof-of-concept, and efficacy...Full timeContract workWork at officeRemote workFlexible hours$114.1k - $211.9k
...motivated and scientifically accomplished Translational Biomarker Strategy Lead to serve as the biomarker representative and strategic... ...milestones.Develop integrated biomarker plans encompassing assays, models, samples, analyses, timelines, and external partnerships....Full timeLocal areaFlexible hours$192k - $265k
...Biomedicines is seeking a creative, rigorous, and execution-oriented machine learning scientist to join our Model-Driven Design team. This role will focus on building the ML methods, data strategies, and closed-loop systems that determine what we design, build, test, and learn...Work at officeShift work- Novartis Group Companies is seeking a Senior Scientist II in Cambridge, MA, to join their Translational Medicine Drug Disposition Discovery Bioanalytical group. This role involves providing lab-based bioanalytical support for drug discovery projects and requires strong...
$179k - $200k
...multiparameter optimization, including ADME/PK considerations, and rapidly... ..., structural biology, DMPK and biology design molecules... ...Experience with computational modeling and simulation for design and... ...and passionate team of scientists Be a part of a cutting-edge...- ...Discovery Immunology Senior Scientist or Principal Scientist to join... ...autoimmune and inflammatory disease models. Build a robust... ...assays, biomarker discovery, PD/PK and efficacy studies). Passion... ...part of their core business strategies, and has been twice named to...
- Kymera Therapeutics is seeking a scientific leader to drive targeted proteomics programs across discovery and preclinical studies. You will design and execute MS-based assays, collaborate with cross-functional teams, and influence program decisions with data. The role requires...
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