DMPK Scientist - PK/PD Modeling & ADME Strategy
Alnylam Pharmaceuticals
Alnylam Pharmaceuticals in Cambridge, MA seeks a DMPK Scientist to design and interpret ADME and PK/PD studies for siRNA and other modalities, applying quantitative pharmacology to guide candidate selection and human dose predictions. The role demands expertise in non-compartmental and compartmental analysis, PBPK, and systems pharmacology, with strong communication and teamwork within a fast-paced environment. #J-18808-Ljbffr Alnylam Pharmaceuticals
- ...Pharmaceuticals, Inc. in Cambridge, MA is seeking a DMPK Scientist to design and interpret in vitro and in vivo ADME and PK/PD studies for siRNA and other modalities,... ...candidate selection. You will build quantitative models and simulations using Phoenix WinNonlin, Monolix...Suggested
- ...quality biotherapeutics development go hand in hand. As a Scientist, PK/PD Modeling & Simulation, you will be responsible for developing, validating... ...will be central to integrating modeling and simulation strategies into Hemab’s clinical programs and advancing our mission...Suggested
- Hemab is seeking a Scientist, PK/PD Modeling & Simulation in Cambridge, MA to develop population PK/PD, PBPK and QSP models to support dose selection... ..., and regulatory teams to inform clinical development strategies and regulatory filings, while contributing to model-...Suggested
- OverviewThe mission of DMPK is to enable... ...and interpreting ADME (absorption, distribution... ...excretion) and PK/PD (pharmacokinetics/... ...pharmacology and modeling, consequently... ...highly motivated scientists across a broad array... ...ResponsibilitiesSupport DMPK strategy across drug...SuggestedFull timeTemporary workLocal areaFlexible hours
- Scorpion Therapeutics in Boston seeks a Translational PK/PD Senior Scientist to drive model-informed decisions across drug discovery and dose prediction. The role integrates PKPD modeling with experimental data, supporting forward and reverse translation and informing modality...Suggested
- .../pharmacodynamic (PK/PD) relationships of... ...Development as a Principal Scientist within Drug... ...Pharmacokinetics (DMPK), providing... ...and implement DMPK strategies to support discovery... ...metabolism, excretion (ADME), PK/PD... ...approaches, including modeling and simulation, to...Full timeTemporary workWork at officeLocal areaFlexible hours
$119.7k - $222.3k
...enthusiastic and motivated PK Sciences... ...intelligence (AI) enabled strategies to transform... ...Drug Disposition (ADME, BA), Modeling & Simulation (M&S)... ...and clinical PK/PD relationships and... ...role overseeing ADME/DMPK project strategy... ...considered for Principal Scientist II. 4+ years of...Full time$129k - $203.1k
...curious and collaborative Senior Scientist for our growing Translational PK/PD organization. The Translational PK... ...Scientist is a skilled mathematical modeler and scientist who designs and... ...supervision, guiding drug discovery strategy with a focus on biologics, protein...For contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work$108.5k - $201.5k
...enthusiastic and motivated PK Sciences project... ...pharmacology strategies to support the... ...Drug Disposition (ADME, BA), Modeling & Simulation (M&S)... ...understanding of PK/PD relationships and... ...role overseeing ADME/DMPK project strategy,... ...for Principal Scientist II • Extensive...$129k - $203.1k
The Translational PK/PD Senior Scientist will: Serve as PK/PD modeler in cross-functional teams to support model-informed decisions on drug discovery, modality selection, and dose prediction. Integrate in vitro and in vivo data to build PKPD, PBPK, QSP, and other mechanistic...$157k - $213k
...motivated and detail-oriented Scientist with strong expertise... ...and Pharmacokinetics (DMPK) sciences to support... ...pharmacokinetic (PK), toxicokinetic (TK),... ...in vivo studies (i.e., ADME, PK, PK/PD) to support advancement... ...-on experience with modeling and simulation is a plusPay...Temporary workSummer workWork at officeLocal area- Merck is seeking a Translational PK/PD Associate Director within our PDMB Translational PK/PD organization in the US. This role focuses... ..., protein therapeutics, and peptides, applying expert PK/PD modeling to guide drug discovery decisions. The successful candidate will...
$89.6k - $166.4k
...CambridgeInternal Title: Senior Scientist ISupport discovery and... ..., and execution of in-vitro ADME assays, while building next... ...and permeability to support PK Science’s strategies.Interpret in vitro ADME data... ...years; MSc: 4+ years of ADME/DMPK experience.Experience working...Full time$126k - $234k
...Internal Title: Principal Scientist II or Senior Principal... ...a translational modeler eager to accelerate oligonucleotide... ...that shape program strategies. As part of a truly... ...) and mechanistic PBPK/PD approaches to inform key... ...apply mechanistic models (PK/PD, QSP, and PBPK/PD)...Full time$179k - $236k
...Scientific Officer, this role leads DMPK and bioanalytical strategy across nonclinical and clinical... ...DMPK and bioanalytical scientist with experience in PK study design, bioanalytical method... ...PK, biomarker, and translational PD readoutsLead method development,...- Merck in Boston, MA is seeking a Translational PK/PD Senior Scientist to design and execute modeling analyses that guide drug discovery for biologics, proteins and peptides. You will serve as a PK/PD modeler in cross-functional teams and help shape dose predictions and...
$115k - $209k
...companies. As part of Flagship’s integrated model of science, entrepreneurship, and... ...Position Summary We are seeking a Principal Scientist to join Pioneering Intelligence (PI), a... ...house expert in clinical and commercial strategy, and will lead the codification of therapeutic...Casual work$146k - $236k
...portfolio of AI-first companies. As part of Flagship’s integrated model of science, entrepreneurship, and capital, it transforms... ...impact through activities that are part of their core business strategies and has been twice named to Fast Company’s annual list of the World...- ...motivated and accomplished scientist to lead the Bioanalytical (BioA) and PK/PD function. This role is... ...pharmacokinetic modeling to translate data into actionable... ...Bioanalytical and PK/PD strategies for ADC programs,... ...Oversee in vitro and in vivo ADME studies, including payload...
$192k - $265k
...Biomedicines is seeking a creative, rigorous, and execution-oriented machine learning scientist to join our Model-Driven Design team. This role will focus on building the ML methods, data strategies, and closed-loop systems that determine what we design, build, test, and learn...Work at officeShift work$114.1k - $211.9k
...motivated and scientifically accomplished Translational Biomarker Strategy Lead to serve as the biomarker representative and strategic... ...milestones.Develop integrated biomarker plans encompassing assays, models, samples, analyses, timelines, and external partnerships....Full timeLocal areaFlexible hours$178.5k - $257.83k
Job title: Distinguished Scientist, Transgenic Model and TechnologyLocation: Cambridge, MAAbout the jobThe Translational In Vivo Models (TIM)... ...technology to devise and execute sophisticated experimental strategies for target validation, proof-of-concept, and efficacy...Full timeContract workWork at officeRemote workFlexible hours- Senior Scientist, Bioanalysis & Biomarkers Nonclinical Development... ...development and biomarker strategy in support of our siRNA... ...will partner closely with DMPK, Pharmacology, Toxicology,... ...support pharmacodynamic (PD) readouts and strengthen PK/PD and exposure-response relationships...Full timeLocal area
$58k - $123.2k
...highly motivated Postdoctoral Scientist to join the Drug Delivery and... ...and pharmacodynamics (PK/PD) to inform dose selection, delivery... ...Contribute to translational strategy discussions by linking molecular... ...in higher vertebrate CNS models. Provide scientific oversight...Full timeFixed term contractH1bVisa sponsorshipWork visaFlexible hours$58k - $123.2k
...group deploys a powerful suite of model-based approaches—including PBPK, PK/PD, QSP, and pharmacometrics to shape... ...curious, and collaborative postdoctoral scientist to join the Global PKPD group... ...insights that inform dosing strategies, risk stratification, or other translational...Full timeTemporary workH1bVisa sponsorshipWork visaFlexible hours- ...stability, permeability, and ADME/PK properties; and using multiparameter... ...to integrate computational modeling, structural information,... ...biophysics, structural biology, DMPK and biology design molecules... ...and passionate team of scientists ~ Be a part of a cutting-...
- ...Description Job Description Scientist/Senior Scientist, Biology... ...translationally relevant kidney disease models to build and lead our kidney... ...knockdown ü In vivo PK/PD, biodistribution, efficacy,... ...hypotheses, delivery strategies, and biomarker plans ·...
$100k - $120k
...StealthCo - Associate Scientist, In Vitro Pharmacology... ...translatability from animal models to humans, which... ...target engagement and PD effect across delivery... ...biodistribution data anchoring PK/PD interpretation In... ...with the team’s biomarker strategy, develop and implement...Shift work$105.04k - $127.29k
...: R1603459 : Senior Associate Scientist, In Vivo Pharmacology, Oncology... ...in vitro, in vivo and ex‑vivo models of Cancer biology and Immuno‑... ...engineering/antibody development, DMPK and translational group. The... ...conduct in vivo efficacy and PK/PD studies and experiments...Hourly payFull timeTemporary workPart timeFor contractorsSummer workLive inWork at officeLocal areaRemote workFlexible hoursShift work$80k - $130k
...motivated and detail-oriented scientist to join our dynamic in... ...pharmacology studies in rodent models relevant to oncology,... ...efficacy, pharmacokinetics (PK), and pharmacodynamics (PD) of new compounds. Perform... ...to optimize therapeutic strategies. Analyze and present data...Full timeWork at office
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