Senior Director, Bioinformatics

Summit Therapeutics Inc. is a biopharmaceutical oncology company with a mission focused on improving quality of life, increasing potential duration of life, and resolving serious unmet medical needs. At Summit, we believe in building a team of world class professionals who are passionate about this mission, and it is our people who drive this mission to reality. Summit’s core values include integrity, passion for excellence, purposeful urgency, collaboration, and our commitment to people. Our employees are truly the heart and soul of our culture, and they are invaluable in shaping our journey toward excellence. Summit’s team is inspired to touch and help change lives through Summit’s clinical studies in the field of oncology. Summit has multiple global Phase 3 clinical studies, including: Non-small Cell Lung Cancer (NSCLC) HARMONi: Phase 3 clinical study which was intended to evaluate ivonescimab combined with chemotherapy compared to placebo plus chemotherapy in patients with EGFR-mutated, locally advanced or metastatic non-squamous NSCLC who were previously treated with a 3rd generation EGFR TKI. HARMONi-3: Phase 3 clinical study which is intended to evaluate ivonescimab combined with chemotherapy compared to pembrolizumab combined with chemotherapy in patients with first-line metastatic NSCLC. HARMONi-7: Phase 3 clinical study which is intended to evaluate ivonescimab monotherapy compared to pembrolizumab monotherapy in patients with first-line metastatic NSCLC. HARMONi-GI3: Phase 3 clinical study intended to evaluate ivonescimab in combination with chemotherapy compared with bevacizumab plus chemotherapy. Ivonescimab is an investigational therapy not presently approved by any regulatory authority other than China’s National Medical Products Administration (NMPA). Summit is headquartered in Miami, Florida, and has additional offices in California, New Jersey, the UK, and Ireland. Overview of Role: The Senior Director of Bioinformatics will provide scientific, strategic, and operational leadership for bioinformatics and computational biology activities supporting discovery, translational research, clinical development, and biomarker programs. This individual will work with a multidisciplinary team responsible for the analysis and interpretation of genomic, transcriptomic, proteomic, spatial, pathology, imaging, molecular modeling and clinical datasets to enable target identification, patient stratification, biomarker discovery, companion diagnostic development, and data-driven decision-making across the company's pipeline. The successful candidate will serve as a key partner to Translational Medicine/Research, Biomarkers and Clinical Development teams and will help shape the organization's long-term data and computational strategy. Role and Responsibilities: Translational Research and Biomarker Development Lead analyses supporting biomarker discovery, patient selection, pharmacodynamic assessments, and mechanisms of response and resistance. Direct integration of multiomic datasets including: Whole genome sequencing (WGS) Spatial transcriptomics Proteomics ctDNA Digital pathology and imaging data Collaborate with translational scientists and clinicians to generate biologically meaningful insights that influence clinical development strategy. Support companion diagnostic (CDx) development and regulatory submissions. Molecular modeling of protein‑protein interactions Strategic Leadership Develop and execute the company's bioinformatics and computational biology strategy across discovery, translational, and clinical programs. Interface with high-performing team of biochemists, computational biologists, and data scientists. Establish scientific priorities, resource plans, and technology roadmaps aligned with corporate objectives. Evaluate emerging technologies in AI/ML, multiomics, digital pathology, spatial biology, and real‑world data analytics. Data Science and AI Drive implementation of machine learning and AI‑based approaches for biomarker identification and predictive modeling. Establish computational methods for integrating molecular and clinical data. Partner with digital pathology and imaging teams on AI‑enabled analyses. Evaluate and implement cloud‑based analytics platforms and scalable computational infrastructure. Scientific Collaboration Partner closely with: Discovery Research Translational Medicine Clinical Development Manage external collaborations with academic institutions, CROs, technology providers, and diagnostic partners. Operational Excellence Establish best practices for data governance, reproducibility, quality control, and regulatory compliance. Oversee bioinformatics infrastructure, cloud computing resources, and data management processes. Ensure timely delivery of analyses supporting key development milestones. All other duties as assigned Experience, Education and Specialized Knowledge and Skills: PhD in Bioinformatics, Computational Biology, Genetics, Genomics, Computer Science, Statistics, Systems Biology, or related field. Minimum of 15+ years of relevant experience in biotechnology, pharmaceutical, diagnostics, or related industries. Strong track record supporting oncology, inflammation, or other therapeutic development programs. Experience with biomarker strategies across multiple stages of drug development. Experience supporting IND, BLA, NDA, PMA, or companion diagnostic submissions preferred. Demonstrated expertise in: NGS analysis pipelines Multiomics data integration Statistical genomics Clinical biomarker analysis Single‑cell and spatial biology analytics Machine learning and predictive modeling Programming languages such as R and Python Data visualization and scientific communication Preferred Qualifications Experience supporting companion diagnostic development and precision medicine strategies. Understanding of FDA, EMA, and global regulatory expectations for biomarker data. Experience with AI‑powered pathology platforms and image analysis. History of scientific publications in high‑impact journals. Experience working in cross‑functional teams in a matrixed environment. This is the pay for this position Pay Transparency

$217,000 - $271,000 USD

Actual compensation packages are based on several factors that are unique to each candidate, including but not limited to skill set, depth of experience, certifications, and specific work location. This may be different in other locations due to differences in the cost of labor. The total compensation package for this position may also include bonus, stock, benefits and/or other applicable variable compensation. Summit does not accept referrals from employment businesses and/or employment agencies in respect of the vacancies posted on this site. All employment businesses/agencies are required to contact Summit’s Talent Acquisition team View email address on click.appcast.io to obtain prior written authorization before referring any candidates to Summit. Summit Therapeutics Inc.is an Equal Opportunity Employer and takes pride in creating and maintaining diverse environment. We do not discriminate in recruitment, hiring, training or promotion or any other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, marital or veteran status, disability, or any other legally protected status. Voluntary Self-Identification For government reporting purposes, we ask candidates to respond to the below self‑identification survey. Completion of the form is entirely voluntary. Whatever your decision, it will not be considered in the hiring process or thereafter. Any information that you do provide will be recorded and maintained in a confidential file. As set forth in Summit Therapeutics’s Equal Employment Opportunity policy, we do not discriminate on the basis of any protected group status under any applicable law. If you believe you belong to any of the categories of protected veterans listed below, please indicate by making the appropriate selection. As a government contractor subject to the Vietnam Era Veterans Readjustment Assistance Act (VEVRAA), we request this information in order to measure the effectiveness of the outreach and positive recruitment efforts we undertake pursuant to VEVRAA. Classification of protected categories is as follows: A "disabled veteran" is one of the following: a veteran of the U.S. military, ground, naval or air service who is entitled to compensation (or who but for the receipt of military retired pay would be entitled to compensation) under laws administered by the Secretary of Veterans Affairs; or a person who was discharged or released from active duty because of a service‑connected disability. A "recently separated veteran" means any veteran during the three‑year period beginning on the date of such veteran's discharge or release from active duty in the U.S. military, ground, naval, or air service. An "active duty wartime or campaign badge veteran" means a veteran who served on active duty in the U.S. military, ground, naval or air service during a war, or in a campaign or expedition for which a campaign badge has been authorized under the laws administered by the Department of Defense. An "Armed forces service medal veteran" means a veteran who, while serving on active duty in the U.S. military, ground, naval or air service, participated in a United States military operation for which an Armed Forces service medal was awarded pursuant to Executive Order 12985. Voluntary Self-Identification of Disability Form CC-305 Page 1 of 1 OMB Control Number 1250-0005 Expires 07/31/2029 Why are you being asked to complete this form? We are a federal contractor or subcontractor. The law requires us to provide equal employment opportunity to qualified people with disabilities. We have a goal of having at least 7% of our workers as people with disabilities. The law says we must measure our progress towards this goal. To do this, we must ask applicants and employees if they have a disability or have ever had one. People can become disabled, so we need to ask this question at least every five years. Completing this form is voluntary, and we hope that you will choose to do so. Your answer is confidential. No one who makes hiring decisions will see it. Your decision to complete the form and your answer will not harm you in any way. If you want to learn more about the law or this form, visit the U.S. Department of Labor’s Office of Federal Contract Compliance Programs (OFCCP) website at . How do you know if you have a disability? A disability is a condition that substantially limits one or more of your “major life activities.” If you have or have ever had such a condition, you are a person with a disability. Disabilities include, but are not limited to: Alcohol or other substance use disorder (not currently using drugs illegally) Autoimmune disorder, for example, lupus, fibromyalgia, rheumatoid arthritis, HIV/AIDS Blind or low vision Cancer (past or present) Cardiovascular or heart disease Celiac disease Cerebral palsy Deaf or serious difficulty hearing Diabetes Disfigurement, for example, disfigurement caused by burns, wounds, accidents, or congenital disorders Epilepsy or other seizure disorder Gastrointestinal disorders, for example, Crohn's Disease, irritable bowel syndrome Intellectual or developmental disability Mental health conditions, for example, depression, bipolar disorder, anxiety disorder, schizophrenia, PTSD Missing limbs or partially missing limbs Mobility impairment, benefiting from the use of a wheelchair, scooter, walker, leg brace(s) and/or other supports Nervous system condition, for example, migraine headaches, Parkinson's disease, multiple sclerosis (MS) Neurodivergence, for example, attention-deficit/hyperactivity disorder (ADHD), autism spectrum disorder, dyslexia, dyspraxia, other learning disabilities Partial or complete paralysis (any cause) Pulmonary or respiratory conditions, for example, tuberculosis, asthma, emphysema Short stature (dwarfism) Traumatic brain injury PUBLIC BURDEN STATEMENT: According to the Paperwork Reduction Act of 1995 no persons are required to respond to a collection of information unless such collection displays a valid OMB control number. This survey should take about 5 minutes to complete. #J-18808-Ljbffr Summit-Therapeutics