Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Principal Medical Director, CVRM

$277.8k
Full-time

Roche

The Opportunity

We are seeking a dynamic medical leader with a background in disciplines related to cardiovascular, renal, and metabolism (CVRM) to join the Medical network at Genentech. The Principal Medical Director will provide exceptional clinical and scientific leadership for medical affairs activities in the area of CVRM and related disorders, aiming to generate and communicate medical evidence that aids practitioners, patients, and payers in making informed health care decisions. The successful candidate will exhibit outstanding communication and leadership skills, building strong relationships with key stakeholders internally and externally. This role requires representing the US Medical function within cross-functional teams and initiatives at Genentech, Roche’s global organization, and external customer engagements, with an emphasis on leading fit-for-purpose teams, prioritizing work flexibly, and engaging in partnerships to address complex multidisciplinary challenges.

Key Responsibilities

  • Clarify and communicate medical perspective to a broader network of Medical Affairs professionals in both home and field organizations.

  • Compile, analyze, and interpret complex datasets from internal and external sources and provide recommendations to CMG and PD teams to support critical decision making for asset development programs

  • Propose clinical and medical strategies that lead to optimal evidence generation and launch readiness in the US

  • Design, execute, and monitor plans, and tactics throughout the product lifecycle.

  • Represent Genentech Medical Affairs externally at key meetings.

  • Develop scientific partnerships with therapeutic area experts and execute collaborations.

  • Lead efficient implementation of medical tactics by leveraging relevant expertise and insights.

  • Execute US Medical/global clinical trial activities conducted as part of Medical Affairs.


Who you are

Qualifications & Experience

  • Advanced Clinical/Science Degree required (MD)

  • Minimum 8-10 years of relevant clinical / medical pharmaceutical/biotechnology industry experience with knowledge of CVRM development and reimbursement landscapes

  • Experience or relevant knowledge of pre-approval drug development trials and post marketing medical evidence generation, including expertise in controlled and observational study designs, data analysis, and clinical/health economic interpretations

  • Understanding of the US health care environment including the payer landscape, evidence based medicine tools and practices, and health technology assessments

  • Ability to navigate complex and challenging situations and flex and thrive in an ambiguous environment.


Location/ Travel Requirements

The position is located in South San Francisco. The position may require up to an additional 35% time traveling.

The expected salary range for this position based on the primary location of South San Francisco, CA is $277,800 - 515,800. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Relocation benefits are not available for this job posting.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Vacancy posted 1 day ago
Similar jobs that could be interesting for youBased on the Principal Medical Director, CVRM in South San Francisco, CA vacancy
  • $215k - $399.4k

     ...patients.The Opportunity: As a Senior Clinical Operations Asset Director, you will provide strategic leadership across one or more development assets in Immunology, Neurology, Ophthalmology, and/or CVRM (Cardiovascular, Renal & Metabolism) while helping shape disease... 
    Suggested
    Full time
    Local area
    Relocation package
    3 days per week

    Genentech

    South San Francisco, CA
    5 days ago
  •  ...****@*****.*** the OpportunityOur client is seeking an experienced and highly motivated Small Molecule CMC Principal / Director to join a growing regulatory and product development consulting team. This role is focused on Chemistry, Manufacturing and... 
    Suggested
    Flexible hours

    Planet Pharma

    Brisbane, CA
    3 days ago
  • $176.5k - $327.9k

    The PositionJoin Genentech in South San Francisco, CA as a Principal Healthcare Compliance Manager, Advisory!Seeking a highly experienced senior compliance professional for a strategic role with significant organizational impact. As a Principal Healthcare Compliance Advisor... 
    Suggested
    Full time
    Work experience placement
    Work at office
    Local area
    Relocation package

    Genentech

    South San Francisco, CA
    2 days ago
  • $153.3k - $284.7k

     ...creates and maintains interactive dashboards that drive high-quality Medical Data Review (MDR) and safety signal detection, aligned with...  ...-Quality (CtQ) endpoints.The Opportunity:The Early Development Principal Statistician is a critical partner in the design and analysis... 
    Suggested
    Full time
    Local area
    Relocation package

    Genentech

    South San Francisco, CA
    5 days ago
  • $374k

     ...vibrant drug-development pipeline, together create an inspiring and exciting place to catalyze and enable medical breakthroughs.Position Description:The Medical Director/Senior Medical Director at Calico will report to the Head of Clinical Sciences and will be responsible... 
    Suggested

    Calico Life Sciences

    South San Francisco, CA
    3 days ago
  • $198.6k

     ...they need today and for generations to come. Creating a world where we all have more time with the people we love. The Sr. Medical Science Director/Sr. Medical Director at Genentech puts patients and science at the center of all actions. They drive medical tactics aimed... 
    Full time
    Local area
    Shift work

    Genentech

    South San Francisco, CA
    4 days ago
  • $324k - $409k

     ...innovation in both the US and China and capitalizing on the strengths of each geographic location.Position Summary:The Senior Medical Director will provide medical support on clinical drug development of the assigned compound(s), including being a key driver of medical... 
    Contract work

    Structure Therapeutics

    South San Francisco, CA
    3 days ago
  • $176.5k - $327.9k

    Key Responsibilities Act as the primary consultant and point‑of‑contact for compliance questions. Develop relationships and provide guidance across functions. Maintain expertise in healthcare compliance legislation and industry practices. Advise Roche global partners on...
    Work at office
    Local area
    Relocation package

    F. Hoffmann-La Roche AG

    South San Francisco, CA
    4 days ago
  • $175k - $200k

     ...Summary We are seeking a highly motivated and experienced Principal Scientist / Associate Director to join our Translational Biology team. The successful...  ..., and a comprehensive benefits package that includes medical, dental, vision, retirement plan, paid time off, and... 

    Dualitas Therapeutics

    South San Francisco, CA
    14 days ago
  •  ...Senior Medical Director South San Francisco, California, United States Medical Director / Senior Medical Director (Neurology & Early Development) Location: South San Francisco, CA (Onsite) Category: Clinical Sciences / R&D Our client is seeking a Medical... 

    Enigma Search

    South San Francisco, CA
    4 days ago
  • $143k - $286k

     ...WalmartBusiness Segment: Home OfficePosition Summary...What you'll do...Principal, Product ManagementPosition Summary Walmart is seeking a...  ...to help associates thrive at work and in life, including: Medical, dental, and vision coverage401(k) and stock purchase programsCompany... 
    Full time
    Temporary work
    Part time

    Walmart

    San Bruno, CA
    4 days ago
  • $143.2k - $265.9k

    The PositionTHE OPPORTUNITYThe Department of Immunology Discovery at Genentech is excited to announce an opportunity for a Principal Scientist, Lab Head, to lead a research group focused on designing next-generation cell therapies to treat autoimmune diseases. The successful... 
    Full time
    Local area

    Genentech

    South San Francisco, CA
    3 days ago
  • Heartflow is a medical technology company advancing the diagnosis and management of coronary artery disease, the #1 cause of death...  ...a product area or portfolio at the scale expected of a Principal or Director-level individual contributor.A note on level: this role is scoped... 
    Local area
    Worldwide
    Relocation

    HeartFlow

    San Francisco, CA
    2 days ago
  • $143.2k - $265.9k

    The PositionThe OpportunityThe Department of Research Oncology at Genentech is excited to announce an opportunity for a Principal Scientist, Lab Head, to join the Synthetic Immunity division encompassing immune engager and CAR-T cell therapy programs. The position will... 
    Full time
    Local area
    Relocation package

    Genentech

    South San Francisco, CA
    3 days ago
  • $143k - $286k

     ...OfficePosition Summary...What you'll do...Role summary: As a Principal Product Manager, you will lead the development and execution of...  ...for a happier mind, body, and wallet. Health benefits include medical, vision and dental coverage. Financial benefits include 401(k),... 
    Full time
    Temporary work
    Part time

    Walmart

    San Bruno, CA
    2 days ago
  • $300k - $400k

     ...to suffer - our goal is to fundamentally change the outcomes for these patients. Alumis is seeking an experienced Executive Medical Director or Senior Medical Director to lead clinical development strategy and execution for Phase 1 and Phase 2 studies in neurology... 
    Remote work

    Alumis

    South San Francisco, CA
    a month ago
  • $214.5k - $398.3k

     ...the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. US Medical, part of Genentech, is passionate about delivering on Our Promise to improve the lives of patients. We foster a culture of... 
    Full time
    Work at office
    Local area
    Shift work
    3 days per week

    Genentech

    South San Francisco, CA
    5 days ago
  • $290k - $305k

     ...clinic. Lycia is headquartered in South San Francisco.    Visit for more information. Lycia Therapeutics is seeking a Medical Director who will play a critical role in the design, execution, and analysis of clinical trials of clinical stage assets. This position... 
    Work at office
    Flexible hours
    2 days per week
    3 days per week

    Lycia Therapeutics

    South San Francisco, CA
    15 days ago
  • $337.5k - $412.5k

     ...to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We're looking for a Senior Medical Director to join our Clinical Sciences team and take a central role in pioneering the future of healthcare. As a Senior Medical Director... 
    3 days per week

    Maze Therapeutics

    South San Francisco, CA
    more than 2 months ago
  • $300k - $358k

     ...for these patients. We are seeking an experienced Senior Medical Director in Clinical Development who will be involved across the full...  ...clinical programs as well as the overall asset strategy. Principal Responsibilities Serve as the physician lead for LUMUS, a... 
    Remote work

    Alumis

    South San Francisco, CA
    a month ago
  •  ...work — both in and out of the office. We're looking for a Principal Art Director, Product to own and evolve Oura's visual language across illustration...  ...color, gender (including pregnancy, childbirth, or related medical conditions), gender identity or expression, genetic... 
    For contractors
    Freelance
    Work at office
    Local area
    Remote work

    Oura

    San Francisco, CA
    1 day ago
  •  ...you could help make great things possible not only in your community, but around the world. We’re looking for a Creative Principal and Art Director who operates at the intersection of brand strategy and culture. A leader who knows how to turn cultural insights into carefully... 
    Work at office
    Local area
    Shift work

    HDR

    San Francisco, CA
    3 days ago
  • $114.1k - $344.4k

    Position Title: Medical Director of Executive Health Location: University of California, San Francisco (UCSF) Reports to: Chief, Division of General Internal Medicine Application Deadline: Open to FillPosition Summary The UCSF Division of General Internal Medicine (DGIM... 

    University of California, San Francisco

    San Francisco, CA
    2 days ago
  • Reference: 629632Posted: 2026-08-07Location: South San Francisco, CaliforniaCompany: Planet Pharma GroupContact: ApplicationsEmail: ****@*****.*** Summary: Clinical Contracts consultant Seeking an Corporate and Clinical Contracts consultant, who...
    Contract work

    Planet Pharma

    South San Francisco, CA
    1 day ago
  • VEG is seeking Medical Directors to lead and elevate veterinary emergency hospitals across our network. As a VEG MD, you will guide hospitals to medical excellence, foster a culture focused on people, mentorship, and patient care, and own strategic initiatives from triage... 

    VEG ER for Pets

    San Bruno, CA
    1 day ago
  • $260k - $290k

     ...making an impact here in ways you never thought possible. VEG is a 2025 and 2026 certified Great Place to Work®. THE JOB Our Medical Directors (MDs) are not only exceptional emergency veterinarians and criticalists. They're also visionary leaders, who take pride in... 
    Full time
    Local area
    Flexible hours
    Night shift
    Weekend work

    VEG ER for Pets

    San Bruno, CA
    1 day ago
  • Alumis seeks a Senior Medical Director in Clinical Development, based in South San Francisco, CA. This role involves overseeing rheumatology and autoimmune drug development from discovery through Phase 3 studies. Responsibilities include leading trials, managing study... 
    Remote job

    Alumis

    South San Francisco, CA
    3 days ago
  • $136.1k - $252.7k

     ...and consumer-driven patient expectations in a rapidly evolving business landscape.The Opportunity As the Commercial Affordability Principal Project Manager, you will serve as a key cross-portfolio subject matter expert driving the end-to-end operational execution of Genentech... 
    Full time
    Contract work
    Local area
    Relocation package
    3 days per week

    Genentech

    South San Francisco, CA
    5 days ago
  • Unlearn.AI, based in San Francisco, is seeking a Principal Product Manager to drive a new AI-focused approach in healthcare. You will lead product strategy execution while collaborating with diverse teams to solve complex challenges faced by biopharma companies. The ideal... 

    Unlearn.AI

    San Francisco, CA
    1 day ago
  • $260k - $365k

    Structure Therapeutics Inc. seeks a Senior Director, Medical Director to spearhead the medical strategy for obesity and metabolic diseases. This role involves building relationships with key opinion leaders, leading publication strategies, and ensuring compliance with regulatory... 
    Remote work

    Jobleads-US

    South San Francisco, CA
    1 day ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Principal Medical Director, CVRM. Be the first to apply!