Senior Medical Director
Enigma Search
Senior Medical Director
South San Francisco, California, United States
Medical Director / Senior Medical Director (Neurology & Early Development)
Location: South San Francisco, CA (Onsite)
Category: Clinical Sciences / R&D
Our client is seeking a Medical Director or Senior Medical Director to lead their Neurological and Neuropsychiatric clinical portfolio.
This is a high-impact role reporting directly to the Head of Clinical Sciences. You will be the clinical architect for programs moving from preclinical discovery into human "Proof-of-Mechanism" and "Proof-of-Concept" trials.
The Impact You Will Make
- Strategic Leadership: Lead high-performing cross-functional teams to translate preclinical data into robust human clinical strategies and biomarker development.
- Experimental Medicine: Design and execute innovative "Phase 0" through Phase 2 studies to demonstrate proof-of-mechanism for novel targets in the neuropsychiatric space.
- Collaborative Discovery: Act as a key interface between research and drug development, working closely with discovery scientists and external partners to shape disease indication strategies.
- Clinical Expertise: Utilize your medical background to guide the development of preclinical models and ensure they align with human clinical needs.
- Regulatory & Scientific Content: Author and provide expert medical oversight for protocols, Investigator Brochures (IBs), Clinical Study Reports (CSRs), and regulatory submissions.
Who You Are
- Physician-Scientist: You hold an M.D. or an M.D./Ph.D. with a deep scientific mindset.
- Neurology Expert: Board certification or eligibility in Neurology or Pediatric Neurology is highly preferred.
- Proven Industry Veteran: You have 5+ years of translational or clinical drug development experience within biotech, pharma, or a top-tier academic research setting.
- Early Phase Specialist: You possess direct experience or a deep working knowledge of early clinical trial methodology (Phase 0, 1, and 2).
- Collaborative Leader: You excel in a matrixed environment, possessing the ability to lead through influence and bring out the best in cross-functional teams.
Why This Role?
This is not a traditional "late-stage" medical monitoring role. This is a position for a scientist-clinician who wants to be at the forefront of Early Development (Translational), working on novel targets that have the potential to redefine how we treat neurological diseases.
Or refer someone
Vacancy posted 5 days ago
Similar jobs that could be interesting for youBased on the Senior Medical Director in South San Francisco, CA vacancy
$285k - $390k
...Medical Director / Senior Medical Director 5948-306 Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery development and commercialization of targeted protein degradation medicines the next frontier in innovative drug design aimed...SeniorFull timeWork at officeNurix
Brisbane, CA11 days ago$337.5k - $412.5k
...Senior Medical Director South San Francisco, CA The Position At Maze Therapeutics, we are assembling a team of passionate, creative, and dedicated professionals to join us on our mission to turn groundbreaking genetic discoveries into life-saving medicines. We...Senior3 days per weekMaze Therapeutics
South San Francisco, CA2 days ago- ...Nurix Therapeutics seeks a Medical Director or Senior Medical Director to support clinical development of targeted protein degradation therapeutics. The role involves cross-functional collaboration with the clinical team, regulatory strategy, protocol development, and...Senior
Nurix Therapeutics
Brisbane, CA11 days ago - ...Nurix Therapeutics seeks a Medical Director or Senior Medical Director to support clinical development of targeted protein degradation therapeutics. The role involves cross-functional collaboration, protocol development, regulatory submissions, and safety oversight of...Senior
Nurix Therapeutics
Brisbane, CA11 days ago - ...Nurix Therapeutics seeks a Medical Director or Senior Medical Director to support clinical development of targeted protein degradation medicines. The role involves providing medical oversight, regulatory strategy, and scientific guidance across the company's oncology...Senior
Nurix Therapeutics
Brisbane, CA11 days ago - Denali Therapeutics Inc. is seeking an Executive Medical Director to lead program strategy and clinical development for TV-mediated therapeutics targeting neurodegenerative diseases. This role requires deep expertise in trial design, regulatory strategy, and cross-functional...Senior
$340k - $380k
...Medical Director/ Senior Medical Director Septerna has an exciting new opportunity to join the team as a Medical Director/ Senior Medical Director, who will provide strategic leadership clinical development strategy, planning, and tactical implementation for all clinical...SeniorFull timeSepterna
South San Francisco, CA3 days ago- ...Septerna seeks a Senior Medical Director to lead clinical development strategy and execution across the company's pipeline. This role involves designing clinical development plans, directing trials across all phases, and serving as the clinical leader for one program while...Senior
Septerna
South San Francisco, CA8 days ago $290k - $305k
...Visit for more information. Lycia Therapeutics is seeking a Medical Director who will play a critical role in the design, execution, and... ...is $290,000-$305,000 for Director and $310,000-$345,000 for Senior Director. Actual salary will depend on the candidate's geographic...SeniorWork at officeFlexible hours2 days per week3 days per weekLycia Therapeutics
South San Francisco, CA21 days ago$270k - $360k
...Medical Director/Senior Medical Director, Clinical Development Tenvie Therapeutics is developing precision‑engineered small molecule therapies to address core drivers of neurological and peripheral diseases: neuroinflammation and cellular dysfunction. Leveraging its...SeniorFull timeLocal areaRemote workTenvie Therapeutics
Brisbane, CA3 days ago- ...AbbVie's mission is to discover and deliver innovative medicines and solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact on people's lives across several key therapeutic areas including...SeniorLocal area
AbbVie
South San Francisco, CA22 days ago - ...serious health issues today and address the medical challenges of tomorrow. We strive to have... ...research. Qualifications Medical Director Qualifications: Medical Doctor (M.D),... ...written English communication skills. Senior Medical Director Qualifications: Medical...SeniorFull timeLocal area
AbbVie
South San Francisco, CAa month ago - ...solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact... ...and other program documents. May oversee the work of Medical Directors and/or Scientific Directors, and of Clinical Scientists working...Senior
- ...Senior Medical Director As a Senior Medical Director, you will play a critical role in planning and executing Sagimet's clinical trial programs. You will collaborate closely with cross-functional team members, including representatives from Clinical Operations, Regulatory...Senior
Sagimet Biosciences
Foster, CA3 days ago $300k - $400k
...suffer - our goal is to fundamentally change the outcomes for these patients. Alumis is seeking an experienced Executive Medical Director or Senior Medical Director to lead clinical development strategy and execution for Phase 1 and Phase 2 studies in neurology and...SeniorRemote workAlumis
South San Francisco, CA28 days ago$292k - $409k
...commercializing best-in-class and first-in-class therapies that address medical conditions with significant unmet needs in oncology,... ...reach, and long-term growth. Job Description The Senior Medical Director will lead late-stage clinical development programs in...SeniorWork at officeWorldwideRelocation packageZai Lab (US) LLC
South San Francisco, CA2 days ago- ...solutions that solve serious health issues today and address the medical challenges of tomorrow. We strive to have a remarkable impact... ...and other program documents. •May oversee the work of Medical Directors and/or Scientific Directors, and of Clinical Scientists working...SeniorLocal area
AbbVie
South San Francisco, CA19 days ago - ...Senior Director, Clinical Pharmacology Kardigan is a heart health company working to make cardiovascular disease preventable, curable... ...Operations, Translational Medicine, Biometrics, Regulatory Affairs, Medical Writing, CMC, Research, and other cross-functional partners...Senior
Kardigan
South San Francisco, CA3 days ago $280.4k - $316.5k
...Senior Director Translational Medicine and Clinical Biomarkers Own the translational science that decides which patients get treated and how leading biomarker strategy across Nurixs entire oncology and immunology portfolio. This is a senior portfolio-level role with...SeniorFull timeLocal areaNurix
Brisbane, CA12 days ago$166k - $209k
...geographic location.Position Summary:The Senior Manager, Clinical Business Systems is responsible... ...applications. Reporting to the Associate Director, GxP Operations, this role is the primary... ...the pharmaceutical, biotechnology, or medical device industries.Hands-on experience...SeniorContract workWork at officeRemote workStructure Therapeutics
South San Francisco, CA3 days ago- ...Senior Director role overseeing translational medicine and clinical biomarker strategy across Nurix's oncology and immunology portfolio. Responsible for biomarker assay development, clinical trial design input, cross-functional leadership, and translating complex science...Senior
Nurix Therapeutics
Brisbane, CA11 days ago - Zai Lab Limited is seeking an experienced Clinical Pharmacology leader to head the Clinical Pharmacology function and advise on strategy, modeling, and regulatory support across its portfolio. The role requires global collaboration with development, translational sciences...Senior
- ...Job Title: Senior Medical Director, Medical Affairs Position Type: Full Time Location: Thousand Oaks, CA or San Francisco Bay Area Company Description: Latigo Biotherapeutics, Inc. is a biotechnology company focused on discovering and developing the next generation...SeniorFull time
Latigo Biotherapeutics
San Francisco, CAa month ago $250k - $311k
...Executive Director, Clinical Operations Xaira Therapeutics is seeking an Executive Director, Clinical Operations to establish and lead... ...closely with the science, the AI and data organization, and senior leadership. The Executive Director will translate development plans...SeniorFlexible hoursXaira Therapeutics
South San Francisco, CA4 days ago- AKASA is seeking a Senior Product Manager to own a flagship AI-native product in the Clinical Documentation and Medical Coding suite. You will help physicians improve documentation quality, identify missing diagnoses and ensure financial integrity for health systems. You...Senior
- Verily is seeking a Sightline Senior Product Manager to drive the platform lifecycle for our population health intelligence suite. You will translate complex pharma and biosecurity workflows into actionable product requirements and steer the scaling of multi-modal forecasting...Senior
- ...Xaira Therapeutics seeks an Executive Director of Clinical Operations to establish and lead clinical operations as the company's first programs enter the clinic. This founding role carries accountability for operational strategy, delivery, quality, and cost across the...SeniorFull time
$340k
...late development (Phase II - IIIA) clinical strategies and plans that deliver medically-differentiated therapies that provide meaningful improvement to patients. The Senior Group Medical Director leads and oversees multiple Clinical Science Teams (CSTs) who are...SeniorLocal areaRelocation packageGenentech
San Francisco, CA4 days ago- Eli Lilly and Company seeks a Senior Director for the LV Tech group to source and evaluate early-stage software and services opportunities, lead due diligence and drive investment transactions. The role requires strategic thinking, strong business acumen, and cross-functional...Senior
- A national recruiting company is seeking a skilled Project Manager to oversee project management of drug development processes. Responsibilities include leading cross-functional teams, managing regulatory submissions, and ensuring projects meet business needs. Ideal candidates...Senior
Do you want to receive more vacancies?
Subscribe and receive similar vacancies to Senior Medical Director. Be the first to apply!
Related searches
- lead clinical data manager South San Francisco, CA
- associate medical director South San Francisco, CA
- occupational health manager South San Francisco, CA
- junior clinical data manager South San Francisco, CA
- clinical manager South San Francisco, CA
- remote medical billing manager South San Francisco, CA
- clinical operations supervisor South San Francisco, CA
- associate director clinical data management South San Francisco, CA
- clinical data manager remote South San Francisco, CA
- director of health and wellness South San Francisco, CA