Senior Scientist, Mass Spectrometry

At Johnson & J&J, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com. As guided by Our Credo, Johnson & J&J is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & J&J, we respect the diversity and dignity of our employees and recognize their merit. Job Function Discovery & Pre-Clinical/Clinical Development Job Sub Function Biological Research Job Category Scientific/Technology All Job Posting Locations Spring House, Pennsylvania, United States of America Job Description About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at We are searching for the best talent for a Senior Scientist, Mass Spectrometry, to be located in Spring House, PA. Purpose: The Senior Scientist, Mass Spectrometry (MS) will join the Biophysics team within the Biologics Discovery (BD) organization. In this role, you will serve as a scientific leader and subject matter expert in advanced structural mass spectrometry, driving strategy, innovation, and application of MS based technologies to support discovery and optimization of protein therapeutics, including multispecific antibodies and antibody–drug conjugates (ADCs). The preferred candidate will have demonstrated scientific expertise in applying advanced mass spectrometry approaches to accelerate characterization of protein therapeutics. You will be responsible for: Providing scientific leadership for protein mass spectrometry capabilities supporting biologics discovery programs. Driving structure–function analyses and mechanistic understanding of target binding to inform lead selection, engineering, and optimization decisions. Designing, interpreting, and integrating advanced MS experiments (intact MS, peptide mapping, HDX-MS) to support complex discovery and developability questions. Championing the development, qualification, and implementation of new analytical technologies, software, and workflows to improve throughput, data quality, and scalability. Acting as a technical advisor to project teams, collaborating closely with biophysics, protein engineering, protein expression, computational biology, and other discovery functions. Representing the function through internal scientific reviews, governance forums, and external publications or presentations, maintaining a strong scientific presence for the organization. Qualifications/Requirements Education PhD in Analytical Chemistry, Biochemistry, Biophysics, or a related scientific field with 2+ years of relevant experience; or a Master's degree with 5+ years; or a Bachelor's degree with 8+ years of directly applicable experience in mass spectrometry-based protein characterization is required. Experience and Skills Required Experience in LC/MS, LC/MS/MS, intact protein MS, and peptide mapping for biologic characterization is required. Expertise in structural mass spectrometry strategies, (e.g., HDX-MS, and/or Footprinting MS) with a demonstrated ability to apply the technique to complex biologics and discovery stage questions is required. Experience in discovery/development of therapeutic antibodies is required. Strong proficiency with mass spectrometry data analysis software (e.g., Protein Metrics, HD Examiner, Proteome Discoverer) and high-quality scientific reporting is required. Ability to communicate complex data and partner effectively in highly matrixed environments is required. Preferred Experience with Trajan HDX–Thermo Orbitrap MS platforms is preferred. Hands on expertise in chemical cross linking and/or protein footprinting MS approaches is preferred. Strong publication and presentation record in structural MS or protein biophysics is preferred. Johnson & J&J is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & J&J is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource. #J-18808-Ljbffr Johnson & Johnson