Senior Principal Scientist, Biologics Discovery Process Research Integrator

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com. As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit. Job Function: Discovery & Pre-Clinical/Clinical Development Job Sub Function: Biotherapeutics R&D Job Category: Scientific/Technology All Job Posting Locations: Malvern, Pennsylvania, United States of America, Spring House, Pennsylvania, United States of America Job Description: About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at We are searching for the best talent for a Senior Principal Scientist, Biologics Discovery Process Research (BDPR) Integrator to be located in Spring House, PA or Malvern, PA. Purpose: The Senior Principal Scientist, will serve as the scientific and strategic connection point between Therapeutic Development & Supply (TDS) and Discovery teams, enabling seamless end-to-end decision-making for biologics programs. This role is deeply technical and focuses on proactively identifying and mitigating development risks during the discovery phase. The leader will ensure that structural, biophysical, expression, and developability insights are assessed and effectively integrated into Chemistry, Manufacturing and Controls (CMC) strategies and program planning. Additionally, the leader will be tasked with identifying early opportunities to assess knowledge gaps to derisk program development. The preferred candidate brings deep scientific expertise in protein structure and developability, strong understanding of CMC development requirements, and a proven ability to influence without authority while navigating complex cross-functional environments. You will be responsible for: Serving as the BDPR integrator on Discovery project teams, aligning strategy, data expectations, and technical risk assessment across Discovery and Development. Providing deep scientific guidance on molecule selection, engineering, developability, manufacturability, expression, and protein structure-function considerations. Identifying and mitigating CMC, technical, operational, and manufacturability risks early, translating findings into clear program recommendations and mitigation plans. Ensuring continuity of scientific rationale and technical context as programs advance from Discovery through candidate nomination and IND-enabling activities. Building trusted cross-functional partnerships and influencing decision-making across Therapeutics Discovery (TD), Preclinical Sciences & Translational Safety (PSTS), Therapeutic Areas (TAs), and TDS in matrixed governance and technical forums. Qualifications/Requirements Education: PhD in Structural Biology, Biochemistry, Biophysics Chemical or Biomedical Engineering, or a closely related field is required. Experience and Skills: Required: A minimum of 10 years of biopharmaceutical R&D experience spanning both Discovery and Development / CMC functions. Deep technical expertise in at least one of the following areas: protein structure, developability principles, and expression considerations and the impact these have on CMC development. Strong understanding of end-to-end biologics development, including the scientific and operational needs of CMC. Proven ability to influence without authority, manage complex partner groups, and deliver results in a matrixed organization. Excellent communication, interpersonal, and scientific storytelling skills. Preferred: Experience supporting IND-enabling or early clinical development efforts. Familiarity with predictive modeling, sequence/structure analysis tools, or computational developability platforms. Experience working across global teams or in high-complexity program environments. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants' needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via internal employees contact AskGS to be directed to your accommodation resource. If you are under 18 years of age, you (the candidate) may need to obtain the necessary working papers or other documentation required by state law to start the assignment, as well as get a parent's consent for the background check. #LI-Hybrid Required Skills: Preferred Skills: Analytical Reasoning, Biochemistry, Biotechnology, Chemistry, Manufacturing, and Control (CMC), Clinical Research and Regulations, Clinical Trial Designs, Collaboration, Data Synthesis, Drug Discovery Development, Molecular Diagnostics, Pharmacovigilance, Process Improvements, Productivity Planning, Program Management, Scientific Research, Tactical Planning, Technical Credibility Johnson and Johnson