Biostatistician Lead

Job Family : Data Science & Analysis

Travel Required :

Up to 10%

Clearance Required :

Ability to Obtain Public Trust

What You Will Do :

Guidehouse is seeking a Biostatistics Lead to provide technical leadership and oversight across statistical analysis, study methodology, surveillance analytics, program evaluation, and research efforts within our Health AI/Data practice. This individual will serve as the senior statistical authority responsible for ensuring methodological rigor, analytical quality, reproducibility, and scientific defensibility across complex public health and healthcare analytics initiatives. The Biostatistics Lead will collaborate closely with epidemiologists, data scientists, informaticists, and client stakeholders to guide statistical approaches, review analytical products, and support evidence-based decision making.

• Serve as the lead biostatistical advisor across surveillance, research, evaluation, and advanced analytics initiatives.

• Lead development of statistical methodologies, Statistical Analysis Plans (SAPs), analytic protocols, sampling approaches, weighting methodologies, and population estimation strategies.

• Provide technical oversight and peer review for statistical analyses, analytic code, modeling approaches, assumptions, and interpretation of findings.

• Design and oversee complex analyses of surveillance, survey, claims, clinical, registry, laboratory, and other real-world health datasets.

• Guide methodological decisions related to study design, causal inference, quasi-experimental methods, observational studies, and evaluation frameworks.

• Lead development and validation of statistical models, surveillance indicators, outcome measures, performance metrics, and population-level estimates.

• Partner with epidemiologists, researchers, and data scientists to translate research and policy questions into statistically rigorous analytic approaches.

• Evaluate and address methodological considerations including bias, confounding, missing data, selection effects, variance estimation, and statistical uncertainty.

• Review and approve statistical deliverables, technical reports, publications, presentations, and dissemination products prior to release.

• Lead interpretation and communication of statistical findings to technical, scientific, operational, and executive stakeholders.

• Mentor and provide technical leadership to biostatisticians, epidemiologists, analysts, and data scientists.

• Contribute to proposal development, solution design, thought leadership, and business development activities requiring advanced statistical expertise.

• Role is contingent upon contract award

What You Will Need :

• Must be a U.S. Citizen or Permanent Resident. and ability to obtain and maintain a Public Trust clearance.

• Master's degree or PhD in Biostatistics, Statistics, Epidemiology (quantitative focus), Mathematics, or related quantitative discipline.

• EIGHT (8) or more years of professional experience applying advanced biostatistical methods within public health, healthcare, surveillance, clinical research, life sciences, or population health environments.

• Experience serving as a lead statistician, technical lead, senior reviewer, or methodological advisor for complex analytics, surveillance, evaluation, or research initiatives.

• Experience in statistical inference, hypothesis testing, study design, power analysis, sample size determination, variance estimation, and population-level inference.

• Experience in applying advanced statistical methodologies including generalized linear models, mixed-effects models, multilevel/hierarchical models, survival analysis, longitudinal modeling, interrupted time series (ITS), difference-in-differences (DiD), propensity score methods, causal inference techniques, survey-weighted analyses, variance estimation, missing data methods, sensitivity analyses, and population-level estimation.

• Experience designing and analyzing studies utilizing complex survey designs, including stratification, clustering, weighting, nonresponse adjustment, and variance estimation.

• Experience in statistical programming using SAS and at least one additional statistical language such as R or Python.

• Experience developing and reviewing Statistical Analysis Plans (SAPs), methodology documents, study protocols, publication-quality analyses, and scientific manuscripts.

• Experience reviewing analytic code, statistical outputs, and analytical approaches for methodological accuracy, reproducibility, and scientific rigor.

• Experience working with large-scale surveillance, claims, clinical, registry, laboratory, electronic health record (EHR), or observational health datasets.

• Experience leading technical workstreams and mentoring multidisciplinary analytic teams.

What Would Be Nice To Have :

• PhD in Biostatistics, Statistics, Epidemiology, or related quantitative discipline.

• Strong understanding of epidemiologic methods and application of biostatistics to surveillance, public health research, and program evaluation.

• Proven ability to communicate complex statistical concepts and findings to both technical and non-technical audiences.

• Experience serving as lead statistician or senior methodological reviewer for large public health, healthcare, or research programs.

• Experience with Bayesian statistical methods, hierarchical Bayesian modeling, machine learning, predictive modeling, or AI-enabled analytics.

• Experience conducting real-world evidence (RWE) studies using observational healthcare datasets.

• Experience supporting federal public health agencies, healthcare organizations, or biomedical research programs.

• Experience developing weighting methodologies and population estimation approaches for surveillance, survey, or public health studies.

• Experience supporting peer-reviewed scientific publications and conference presentations.

• Experience with cloud analytics environments such as Databricks, Snowflake, Azure, AWS, or Palantir Foundry.

• Experience supporting SAS-to-R or SAS-to-Python migration and statistical validation efforts.

• Experience with HIV surveillance processes and data.

• Experience working with state public health agencies.

• Experience leading multidisciplinary analytic teams in consulting, research, or government environments.

The annual salary range for this position is $92,000.00-$153,000.00. Compensation decisions depend on a wide range of factors, including but not limited to skill sets, experience and training, security clearances, licensure and certifications, and other business and organizational needs.

What We Offer:

Guidehouse offers a comprehensive, total rewards package that includes competitive compensation and a flexible benefits package that reflects our commitment to creating a diverse and supportive workplace.

Benefits include:

• Medical, Rx, Dental & Vision Insurance

• Personal and Family Sick Time & Company Paid Holidays

• Parental Leave

• 401(k) Retirement Plan

• Group Term Life and Travel Assistance

• Voluntary Life and AD&D Insurance

• Health Savings Account, Health Care & Dependent Care Flexible Spending Accounts

• Transit and Parking Commuter Benefits

• Short-Term & Long-Term Disability

• Tuition Reimbursement, Personal Development, Certifications & Learning Opportunities

• Employee Referral Program

• Corporate Sponsored Events & Community Outreach

• Care.com annual membership

• Employee Assistance Program

• Supplemental Benefits via Corestream (Critical Care, Hospital Indemnity, Accident Insurance, Legal Assistance and ID theft protection, etc.)

• Position may be eligible for a discretionary variable incentive bonus

About Guidehouse

Guidehouse is an Equal Opportunity Employer–Protected Veterans, Individuals with Disabilities or any other basis protected by law, ordinance, or regulation.

Guidehouse will consider for employment qualified applicants with criminal histories in a manner consistent with the requirements of applicable law or ordinance including the Fair Chance Ordinance of Los Angeles and San Francisco.

If you have visited our website for information about employment opportunities, or to apply for a position, and you require an accommodation, please contact Guidehouse Recruiting at View phone number on aiapply.co or via email at View email address on aiapply.co. All information you provide will be kept confidential and will be used only to the extent required to provide needed reasonable accommodation.

All communication regarding recruitment for a Guidehouse position will be sent from Guidehouse email domains including @guidehouse.com or View email address on aiapply.co. Correspondence received by an applicant from any other domain should be considered unauthorized and will not be honored by Guidehouse. Note that Guidehouse will never charge a fee or require a money transfer at any stage of the recruitment process and does not collect fees from educational institutions for participation in a recruitment event. Never provide your banking information to a third party purporting to need that information to proceed in the hiring process.

If any person or organization demands money related to a job opportunity with Guidehouse, please report the matter to Guidehouse’s Ethics Hotline. If you want to check the validity of correspondence you have received, please contact View email address on aiapply.co. Guidehouse is not responsible for losses incurred (monetary or otherwise) from an applicant’s dealings with unauthorized third parties.

Guidehouse does not accept unsolicited resumes through or from search firms or staffing agencies. All unsolicited resumes will be considered the property of Guidehouse and Guidehouse will not be obligated to pay a placement fee.