Senior Laboratory Manager, Translational Oncology New San Francisco, CA; South San Francisco

Senior Laboratory Manager, Translational Oncology About the Role We are seeking an experienced Senior Laboratory Manager, Translational Oncology to lead day-to-day operations across our Discovery and Translational Oncology research organization. This role sits at the intersection of scientific fluency and operational excellence - the ideal candidate brings hands-on research experience, a track record of running complex laboratory environments, and the organizational instincts to keep multiple research groups moving efficiently. You will partner closely with scientists, facilities, procurement, safety, and business operations to deliver a high-functioning, compliant, and sustainable lab environment. Laboratory Operations & Infrastructure Lead lab build-out including assisting with instrument procurement, installation, and validation. Own end-to-end lab operations across multiple discovery and translational oncology storage infrastructure, and shared-resource coordination. Lead laboratory consolidation, cleanout, decommissioning, and relocation efforts, including equipment mapping and workflow optimization. Drive sustainability initiatives (e.g., Green Lab certification programs) and identify opportunities for energy and resource efficiency. Oversee compliance with EH&S, institutional safety standards, and equipment qualification requirements. Cross-Functional Partnerships Serve as the primary operational liaison to Facilities, Procurement, Instrument Services, Research Supply, Safety, and Business Operations. Work with IT to integrate computational pipelines with existing Natera compute infrastructure. Coordinate equipment sharing with lab managers from other departments and facilities. Manage vendor relationships, capital planning, and equipment procurement in alignment with research priorities and budget constraints. Coordinate onboarding and offboarding of laboratory personnel, including space assignments and equipment access. Scientific & Team Engagement Develop functional assays or support translational research workflows as needed, engaging meaningfully with scientific teams on operational decisions. Lead recurring lab forums and operational communication cadences to keep research and operations teams aligned. Mentor and support junior lab staff; model best practices in laboratory conduct, documentation, and organization. What You Bring B.S. or higher in a life science discipline (Cell Biology, Molecular Biology, Biochemistry, or related field); advanced degree a plus. 10+ years of experience in a research laboratory setting, with at least 3-5 years in a formal lab management or operations leadership role within biotech or pharma. Direct experience supporting translational or oncology research programs. Demonstrated ability to manage large-scale laboratory infrastructure projects — relocations, equipment fleet management, cold-storage optimization, or similar. Familiarity with flow cytometry, cell-based assays, tissue culture, and/or preclinical research workflows. Experience with single-cell sequencing and spatial genomics technologies is a plus. Strong cross-functional collaboration skills; comfortable working across scientific, facilities, compliance, and business operations stakeholders. Experience with sustainability or green lab programs is a plus. Excellent organizational, communication, and project management skills; able to manage multiple priorities across concurrent workstreams. Compensation & Total Rewards This range reflects a good-faith estimate of the base pay we reasonably expect to offer at the time of hire. Final compensation will vary based on experience, qualifications, and internal equity considerations. This position is also eligible for additional compensation and benefits through Natera's robust Total Rewards program, including: Annual performance incentive bonus Long-term equity awards 401(k) with company match Generous paid time off and company holidays Additional wellness and work-life benefits Compensation Range: $142,300 - $177,850 USD Our Opportunity Natera is a global leader in cell-free DNA (cfDNA) testing, dedicated to oncology, women's health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives. The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world-class institutions, who care deeply for our work and each other. When you join Natera, you'll work hard and grow quickly. Working alongside the elite of the industry, you'll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management. What We Offer Competitive benefits — comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Free testing and fertility care benefits for employees and immediate families. Paid parental leave, 401(k) benefits, commuter benefits and much more. Generous employee referral program. Equal Opportunity Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities, and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide. All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability, or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws. If you are based in California, we encourage you to read this important information for California residents. We do not request interviews via text messages and do not ask for personal information until a candidate has engaged with the company and has spoken to a recruiter and the hiring team. #J-18808-Ljbffr Natera, Inc.