Director, Revenue Planning & Commercial Finance

Director, Revenue Planning & Commercial Finance

Job Category : General & Administrative - Ionis

Requisition Number : IONIS003608

• Posted : October 19, 2026
• Full-Time
• On-site

Locations

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Headquartered in Carlsbad, California, and with offices in Boston, Massachusetts, and Dublin, Ireland, Ionis has been at work for more than three decades discovering medical breakthroughs that have redefined life for people with serious diseases. We’re pioneers in RNA-targeted medicines, and our platform continues to revolutionize drug discovery and transform lives for patients with unmet needs. With multiple marketed medicines and a leading pipeline in neurology, cardiology and select areas of high patient needs, we continue to drive innovation in RNA therapies in addition to advancing new approaches in gene editing to provide greater value to patients and are well positioned financially to deliver on our strategic goals.

At Ionis, we pride ourselves on cultivating a challenging, motivating and rewarding environment that fosters innovation and scientific excellence. We know that our success is a direct result of the exceptional talents and dedication of our employees.

With an unprecedented opportunity to change the course of human health, we look to add diverse individuals, skill sets and perspectives to our exceptional team. We continue to invest time, money and energy into making our onsite, hybrid and remote work environments a place where solid and lasting relationships are built and where our culture and employees can thrive.

We’re building on our rich history, and we believe our greatest achievements are ahead of us. If you’re passionate about the opportunity to have meaningful impact on patients in need, we invite you to apply and join us. Experience and contribute to our unique culture while you develop and expand your career!

DIRECTOR, REVENUE PLANNING & COMMERCIAL FINANCE

SUMMARY:

We are seeking a Director, Revenue Planning & Commercial Finance to provide strategic financial leadership, business partnership, and decision support across Ionis' Commercial organization. This role reports to the Executive Director, Global Product Strategy and Operations (GPSO) Finance, and serves as the finance partner responsible for revenue forecasting and commercial investment analysis, partnering closely with Commercial, Insights & Analytics, Market Access, Accounting, and Finance to support informed business decisions and drive sustainable growth.

The Director will lead the Company's revenue planning and forecasting processes, integrating demand forecasts, gross-to-net assumptions, and other key business drivers into a comprehensive financial outlook. This individual will evaluate and challenge assumptions, identify risks and opportunities, and provide actionable insights into revenue performance, commercial investments, and resource allocation decisions.

As a key finance partner to GPSO, Commercial, and Finance leadership, the Director will translate complex business dynamics into clear, executive-level insights and recommendations that support strategic decision-making, drive cross-functional alignment, and improve commercial investment effectiveness.

WORK LOCATION: onsite/hybrid – Carlsbad, CA

RESPONSIBILITIES

Revenue Forecasting & Planning

• Lead the end-to-end revenue forecasting process across commercial products, including monthly forecasts, quarterly updates, annual budgets, and support for strategic financial plans.
• Partner with Insights & Analytics, Market Access, Accounting, and Commercial stakeholders to evaluate key assumptions, risks, opportunities, pricing, and gross-to-net impacts.
• Integrate demand forecasts, gross-to-net assumptions, and commercial drivers into a comprehensive revenue outlook.
• Challenge assumptions and drive alignment to improve forecast accuracy and decision quality.
• Develop and communicate forecast risks, opportunities, and business implications to senior leadership.

Commercial Finance Partnership & Investment Effectiveness

• Evaluate product performance, commercial initiatives, and investment opportunities through a financial lens to support planning, forecasting, and resource allocation decisions.
• Assess the effectiveness and return on commercial investments, including incentive compensation, field force investments, promotional activities, and other investments.
• Support resource allocation decisions through financial analysis, business cases, and scenario planning.
• Lead forecasting, accrual management, and financial oversight of commercial incentive compensation programs, including target-setting support and performance analyses.

Executive Reporting & Strategic Decision Support

• Lead development of revenue forecast reviews and executive presentations for Finance leadership and the CFO.
• Develop concise, insight-driven narratives that clearly communicate business performance, forecast changes, key assumptions, and emerging risks and opportunities.
• Facilitate discussions with senior leadership to drive alignment and informed decision-making.
• Perform ad hoc analyses and scenario planning to support strategic initiatives and key business decisions.

Process Leadership & Continuous Improvement

• Maintain effective forecasting governance and planning processes, identifying opportunities to improve forecasting, analytics, reporting, and decision-support capabilities
• Lead cross-functional forecast review forums and drive accountability across stakeholders.
• Develop scalable processes and frameworks that support organizational growth and evolving business needs.
• Lead through ambiguity, proactively identifying solutions and driving progress across complex initiatives.

REQUIREMENTS

• Bachelor's Degree in Finance, Accounting, Economics, Business, or a related field; MBA, CPA, CMA, or other advanced credentials are a plus.
• At least 15 years of progressive finance experience demonstrating continued growth in scope, leadership, and business impact. Life Sciences, Biotechnology, Pharmaceutical, or Healthcare industry experience strongly preferred.
• Experience leading financial planning (FP&A), forecasting, commercial finance, revenue planning, or related finance functions.
• Strong understanding of financial statements, forecasting methodologies, and business planning processes.
• Proven ability to partner effectively with senior leaders and cross-functional stakeholders to influence decisions and drive business outcomes.
• Strong analytical, problem-solving, and strategic thinking skills, with the ability to translate complex financial information into actionable business insights.
• Excellent written, verbal, and presentation communication skills, including experience communicating with executive leadership.
• Proven ability to lead through ambiguity, manage competing priorities, and drive results in a dynamic environment.
• Experience leading complex cross-functional initiatives and building alignment across diverse stakeholder groups.
• Advanced Excel and PowerPoint skills; experience with financial planning and reporting systems is preferred.

The pay scale for this position is $173,114 to $227, 736.

NO PHONE CALLS PLEASE. PRINCIPALS ONLY.

Ionis Pharmaceuticals, Inc. and all its subsidiaries are proud to be EEO employers.

Equal Opportunity Employer
This employer is required to notify all applicants of their rights pursuant to federal employment laws.For further information, please review the Know Your Rights notice from the Department of Labor.