Executive Director, Portfolio Management

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity We are looking for a highly motivated individual with experience in portfolio management, decision analysis and a passion for developing solutions for complex problems to build out this cross-functional capability and help shape our portfolio strategy. This position will report to the SVP, Development Management and Program Leadership and will be based at our headquarters in Redwood City, CA. In this highly cross functional role, you will be expected to evolve the wider portfolio management capability within Revolution Medicines and closely collaborate with Portfolio Working Group, Disease Area Teams, Program Teams, Life Cycle Teams, Analytics and Insights, Finance, Commercial and many other relevant functions. You must be entrepreneurial, able to “roll up their sleeves” and thrive in a fast‑paced, highly cross‑functional environment. You are an exceptional strategic and critical thinker, have a passion for interpreting and analyzing complex data, and have strong interpersonal skills that you will leverage to successfully partner cross‑functionally with internal teams and senior stakeholders. Responsibilities Create and deliver robust Revolution Medicine portfolio strategies that provide the scaffolding for molecule decisions. Actively manage the Revolution Medicine portfolio with an enterprise mindset, providing data‑driven actionable portfolio insights that contextualize individual molecule and project decisions. Identify current and future needs and evolve capabilities to remain fit for purpose as our portfolio continues to increase in complexity. Implement best practices including development and use of qualitative and quantitative methods for portfolio prioritization, decision analysis, project trade‑offs, and assigning probability of success to support decision making. Drive the development and collation of R&D inputs for program and portfolio evaluations, including target product profiles, development plans and probability of success assessment, and ensure consistency with financial and commercial inputs. Serve as an active thought partner to decision‑makers and closely work with Program Teams, Life Cycle Teams and relevant functions on areas including, but not limited to defining/scoping of tactics to deliver on defined portfolio strategies; content expertise to develop strategic options and valuations; trade‑off analysis, and/or decision framing including portfolio context; application of analytical tools and frameworks to clearly present options and solutions to optimize the portfolio. Maintain a detailed understanding of the shape and drivers of the portfolio through proactive involvement with key stakeholders and assess impact of external developments on our portfolio. Lead and manage other high impact projects that arise outside of regular portfolio planning cycles, ensuring that these one‑off initiatives are aligned to overall business objectives. Contribute to the overall strategy and development of Development Management and Program Leadership. Uphold an open, inclusive and collaborative culture with a focus on shared learning and people development. Required Skills, Experience, and Education 15+ years’ experience in the biotech/pharmaceutical industry with 5+ years’ experience in portfolio management, portfolio planning or similar function(s). Intensive experience with clinical development stages and understanding of the external landscape and key players in the Oncology space. Strong insight into strategic and commercial drivers of the pharmaceutical market with a thorough understanding of the drug development and commercialization process. Exceptional analytical and problem‑solving skills, with the ability to interpret complex data, and present it in a clear and concise manner. Proficiency in utilizing data to drive strategic decision making and portfolio optimization. Proven ability to think strategically with sound judgment and decision‑making. Demonstrated leadership, influencing skills, critical thinking, creativity, and ability to manage complexity and operate amidst ambiguity. Excellent interpersonal skills and the ability to build and maintain positive work relationships to effectively interface at all levels across the organization. Demonstrated ability to lead cross‑functional teams and drive results in a dynamic and fast‑paced environment. Preferred Skills A. or BSc. in Life Sciences with a MSc, MBA or Ph.D. Line management experience preferred, matrix management experience acceptable alternative. Base Pay Salary Range $265,000 - $331,000 USD for candidates working onsite at Redwood City, CA. Equal Employment Opportunity Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. #J-18808-Ljbffr Revolution Medicines