Postdoctoral Research Fellow

Site The Brigham and Women's Hospital, Inc. Overview Mass General Brigham relies on a wide range of professionals, including doctors, nurses, business people, tech experts, researchers, and systems analysts to advance our mission. As a not‑for‑profit, we support patient care, research, teaching, and community service, striving to provide exceptional care. We believe that high‑performing teams drive groundbreaking medical discoveries and invite all applicants to join us and experience what it means to be part of Mass General Brigham. Job Summary Postdoctoral position available to study mechanisms of response to immune checkpoint inhibitors in kidney cancer. Immunotherapy with immune checkpoint inhibitors (e.g. anti‑PD‑1/PD‑L1 agents) has demonstrated clinical efficacy in metastatic renal cell carcinoma (mRCC). Unfortunately, only a subset of mRCC patients responds to these agents. To guide further clinical development of immune checkpoint inhibitors in kidney cancer, we aim to 1) develop and validate tissue‑based predictors of drug response using both genomics approaches and in situ analyses; 2) understand the mechanism of action of PD‑1/PD‑L1 blockade to facilitate the development of highly active combination regimens. Qualifications Requirements: We are seeking a highly motivated applicant with an M.D. or M.D./Ph.D. with formal training in Anatomic Pathology (at least 1 year in residency program) and laboratory experience in pathology and/or molecular biology. Background in bioinformatics/computational biology is desirable. Excellent written and oral communication skills are required. The candidate must be willing to commit to the position for at least two years. Contact Sabina Signoretti M.D. Department of Pathology Brigham and Women's Hospital Thorn Building 504A 75 Francis Street Boston, MA 02115 View phone number on click.appcast.io View email address on click.appcast.io Additional Job Details Remote Type: Onsite Work Location: 75 Francis Street EEO Statement 2200 The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at View phone number on click.appcast.io. Mass General Brigham Competency Framework At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People‑Focused, half Performance‑Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline. #J-18808-Ljbffr Brigham and Women's Hospital