Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Scientist II, Upstream Polysaccharide Process Development

Vaxcyte

Vaxcyte seeks a Scientist II to design and execute upstream fermentation studies for polysaccharide vaccine manufacturing. The role involves process development, optimization, and troubleshooting using microorganisms, with significant hands-on laboratory work and cross-functional collaboration.

Responsibilities

  • Design, execute, and analyze upstream polysaccharide fermentation studies for process development and optimization
  • Develop and troubleshoot fermentation processes to improve yield, quality, and consistency
  • Perform bioreactor operations, maintenance, troubleshooting, and automation script development
  • Investigate anomalous results through root-cause experimentation and structured problem-solving
  • Lead assigned project activities and provide technical guidance to junior team members

Requirements

  • Practical laboratory experience in microbial fermentation and upstream process development
  • Proficiency with bioreactor systems and fermentation equipment operation
  • Knowledge of statistical design of experiments and process optimization methods
  • Strong experimental design, data interpretation, and technical decision-making skills
  • Experience with microbiology and analytical testing in bioprocess contexts
  • Ability to author technical documents and present scientific results
Vacancy posted 5 days ago
Similar jobs that could be interesting for youBased on the Scientist II, Upstream Polysaccharide Process Development in San Carlos, CA vacancy
  • $146k - $171k

     ...decision making.Summary:The Development organization is comprised of four Process teams: Protein, Polysaccharide, Conjugate Drug Substance (Conjugation...  .... Vaxcyte is looking for a Scientist II with experience in microbial fermentation and upstream process development to join... 
    Suggested

    Vaxcyte

    San Carlos, CA
    4 days ago
  • $169.32k - $219.12k

     ...role in the discovery and development of life-changing scientific...  ...Job DescriptionThe Senior Scientist, Cell Culture Process Development (Pivotal &...  ...during pivotal phases (phases II/III and post-launch). In...  ...employing modeling techniques for upstream process development and... 
    Suggested
    Full time
    For contractors
    Local area
    Flexible hours

    GILEAD Sciences

    Foster, CA
    2 days ago
  • $146k - $171k

     ....Summary:Vaxcyte is looking for a Scientist II, Conjugation Development. The candidate’s primary responsibility...  ...understanding of the conjugation process. In parallel, the candidate will...  ...modified polysaccharides and polysaccharide-protein conjugates. The ideal candidate... 
    Suggested
    Contract work

    Vaxcyte

    San Carlos, CA
    3 days ago
  •  ...@staffingfuture.comScientist II, Cancer Models, Translational...  ...Research The Opportunity:As a Temp Scientist II on the Cancer Models team,...  ...preclinical cancer model development and acquisition projects from...  ...access and material-transfer processes.Experience with PDX/PDO... 
    Suggested
    Contract work
    Temporary work

    Planet Pharma

    Redwood City, CA
    1 day ago
  • $105k - $123k

     ...making.Summary:Vaxcyte is seeking an accomplished Associate Scientist II, Immunoassay Development to join the CMC Immunoassay group. This role will...  ...recruitment activities. Vaxcyte has an established recruitment process for all positions prior to issuing an offer for... 
    Suggested

    Vaxcyte

    San Carlos, CA
    3 days ago
  •  ...Description About AbbVie CMC Development The Biologics CMC...  ...of highly experienced scientists and managers who have...  ...Senior Scientist II to join the Downstream...  ...downstream processes for biologic drug substance...  ...matrixed organization with upstream, analytical, drug... 
    Full time
    Local area

    AbbVie Inc.

    South San Francisco, CA
    more than 2 months ago
  •  ...drugs used in the treatment of HIV, hepatitis B, hepatitis C, and influenza, including Harvoni and Sovaldi. Job Title: Scientist - Process Development - IV Location: Foster City, CA 94404 Duration: 12 Months Job Type: Temporary Assignment Work Type: Onsite... 
    Temporary work

    TekWissen LLC

    Foster, CA
    1 day ago
  •  ...Biologics Analytical Research & Development (Biologics ARD) is a global...  ...We are a world-class team of scientists and leaders united by a...  ...and highly motivated Scientist II to join our Quality Control team...  ...the exception/quality event process. In this role, you will represent... 
    Full time
    Temporary work
    Local area
    Flexible hours

    AbbVie Inc.

    South San Francisco, CA
    a month ago
  • $45 - $50 per hour

     ...biotechnology company pioneering the development of allogeneic chimeric...  ...motivated Senior Associate Scientist to support the development...  ...clinical-scale manufacturing processes for Allogene’s CART...  ...processes including operation in upstream genetic modification and bioreactor... 
    Hourly pay
    Contract work
    Temporary work
    Internship
    Local area

    Allogene Therapeutics

    South San Francisco, CA
    a month ago
  • $169.32k - $219.12k

     ...Optimize and characterize cell culture processes for monoclonal antibodies and novel modalities...  ...high-performing cell culture process development team Conduct statistical analyses...  ...of cell culture media development and upstream process modeling preferred... 

    Gilead Sciences

    Foster, CA
    21 days ago
  •  ...Revolution Medicines seeks a Senior Safety Scientist II to provide pharmacovigilance and safety...  ...across early and late-phase clinical development. The role involves medical review of...  ...communication skills Experience with signal detection and benefit-risk evaluation processes... 

    Revolution Medicines

    Redwood City, CA
    7 days ago
  •  ...world-wide. Position: Associate Scientist II - Analytical Ops Location: Foster...  ...Associate Scientist to support purification process development during pivotal and commercial...  ...focuses on high throughput purification of upstream/cell culture samples and supports... 
    Contract work
    Temporary work

    TekWissen LLC

    Foster, CA
    1 day ago
  • $132k - $166k

     ...service of patients.The Opportunity:As a Scientist II, Biomarker Sciences/Translational...  ...findings into testable hypotheses and drug-development insights.Demonstrated experience and proficiency...  ...email or phone. We will only collect, process and use any personal data that you... 
    Full time
    Local area
    Worldwide

    Revolution Medicines

    Redwood City, CA
    3 days ago
  • $202k - $238k

     ...Opportunity:We are seeking a Machine Learning Scientist II to help accelerate drug discovery...  ..., drug discovery workflows, assay development, microscopy, experimental design, or biological...  ...email or phone. We will only collect, process and use any personal data that you... 
    Full time
    Local area
    Worldwide

    Revolution Medicines

    Redwood City, CA
    2 days ago
  • $165k - $193k

     ...seeking an accomplished Senior Scientist, Immunoassay Critical...  ...strategic leadership for the development, qualification, characterization...  ...with conjugated vaccines, polysaccharide-protein conjugates, multivalent...  ...an established recruitment process for all positions prior to... 
    Contract work

    Vaxcyte

    San Carlos, CA
    2 days ago
  • $170k - $212k

     ...accomplished, independent and creative Senior Scientist II to join our Computational Chemistry...  ..., and data science to accelerate the development of transformative therapeutics for...  ...compounds and accelerate lead optimization processes.Critically evaluate, implement, and apply... 
    Full time
    Local area
    Worldwide

    Revolution Medicines

    Redwood City, CA
    4 days ago
  •  ...biologist who is dedicated to the discovery and development of innovative therapeutics, both small...  ..., with a focus on immuno-oncology. The Scientist I will perform tumor efficacy and PK/PD...  ...5+ years of experience Scientist II: MS with 5+ years of experience, or BS... 
    Full time
    Temporary work
    Local area

    AbbVie Inc.

    South San Francisco, CA
    21 days ago
  • $121.49k - $151.85k

     ...Job Description Job Description R&D Partners is seeking to hire a Scientist, Biologics Pivotal Formulation and Process Development in Foster City, CA.   Your main responsibilities as a Scientist, Biologics Pivotal Formulation and Process Development: ·... 

    RD Partners

    San Mateo, CA
    4 days ago
  •  ...Job Description The Biologics CMC Development team at AbbVie in the Bay Area has a long...  ...is within a team of highly experienced scientists and managers who have directly enabled...  ...group, you will apply strong downstream process-development expertise to design robust,... 
    Full time
    Contract work
    Local area

    AbbVie Inc.

    South San Francisco, CA
    5 days ago
  • $60 - $70 per hour

    Description:: We are seeking a highly motivated, self-driven and collaborative individual to join the Process and Product Development organization. The successful candidate will serve as a technical lead working with internal teams and external CDMOs focused on development... 
    Hourly pay
    Contract work
    Temporary work
    Internship
    Local area
    Remote work

    Allogene Therapeutics

    South San Francisco, CA
    a month ago
  • $115.2k - $158.4k

     ...Department Summary The Technology Development Department is responsible...  ..., scale manufacturing processes, and drive sustaining projects...  ...production. Position Summary The Scientist I in S&S will help ensure...  ...relationships between upstream process variables, QC metrics... 
    Work experience placement
    Work at office
    Work from home

    Guardant Health, Inc.

    Redwood City, CA
    1 day ago
  • Scientist II/Senior Scientist, Protein Science (Menlo Park, CA) Location: Menlo Park, CA Job...  ...collaborative, interdisciplinary drug‑development team leveraging the discovery of novel...  ...interpret results to guide decision‑making processes. Proactively identify workflow... 
    Flexible hours

    Cedent

    Menlo Park, CA
    2 days ago
  •  ...Vaxcyte seeks a Scientist II for Analytical Development to execute analytical testing and support method development for vaccine programs. The role involves routine and non-routine assays, troubleshooting, documentation, and cross-functional collaboration with moderate... 
    Contract work

    Vaxcyte

    San Carlos, CA
    27 days ago
  • $169.32k - $219.12k

     ...Gilead Sciences seeks a senior scientist to lead purification process development for biologic therapeutics during pivotal and commercial stages. The role involves designing experiments, managing development strategies, supporting technology transfer, and collaborating... 

    Gilead Sciences

    Foster, CA
    9 days ago
  •  ...AbbVie seeks a Senior Scientist II for CMC bioprocess purification development in South San Francisco. The role involves designing and optimizing downstream purification processes for complex biologics across development stages, leading technology transfer activities,... 
    Contract work

    AbbVie

    South San Francisco, CA
    13 days ago
  • $47.19 - $58.99 per hour

     ...values - they’re how we work every day. About The Role The Clinical Laboratory Scientist II will be responsible for performing a variety of laboratory procedures involved in end-to-end processing of biological samples to enable successful downstream next-generation... 
    Immediate start
    Worldwide

    Natera

    San Carlos, CA
    3 days ago
  •  ...facility. We have entered the LCLS-II era, a new accelerator...  ...precision. The Science Research and Development (SRD) division at LCLS...  ...Head will lead a team of staff scientists within the department provide...  ...decisions of our peer-review process. Facility Development: Work... 
    Work at office
    Local area

    Stanfordlivetickets

    Menlo Park, CA
    1 day ago
  •  ...Vaxcyte seeks an Associate Scientist II to support immunoassay development and lifecycle management within its CMC group. The role involves hands-on assay execution, reagent preparation, data analysis, and laboratory documentation to advance vaccine characterization across... 

    Vaxcyte

    San Carlos, CA
    4 days ago
  • $125k - $140k

     ...SUMMARYNatera is seeking a highly motivated Scientist, R&D - Immunohistochemistry (IHC) & Histology to join the Oncology Product Development team. This role will focus on the...  ...variables, including tissue fixation, FFPE processing, embedding, sectioning, H&E staining, and... 
    Work at office
    Immediate start
    Remote work
    Worldwide

    Natera

    San Carlos, CA
    4 days ago
  • $120.7k - $224.1k

     ...This opening is for a Senior Scientist position in the translational...  ...tPKPD) department within the Development Sciences division in Genentech...  ...g., WinNonlin, NONMEM, ADAPT II, Matlab, Simbiology, R)...  ...relation to the online application process, please contact us by... 
    Full time
    Local area
    Relocation package

    Genentech

    South San Francisco, CA
    2 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Scientist II, Upstream Polysaccharide Process Development. Be the first to apply!