Senior Distinguished Scientist for Transgenic Model and Technology

Job title: Senior Distinguished Scientist for Transgenic Model and Technology Location: Cambridge, MA About the job The Translational In Vivo Models (TIM) department within Sanofi's R&D is seeking an exceptional Senior Distinguished Scientist to lead our Transgenic Model & Technology (TMT) function globally. This strategic leadership role will drive innovation in genome engineering and genetically modified model development to accelerate drug discovery across all therapeutic divisions. As the Global Head of Transgenic Biology, you will ensure our organization remains at the forefront of technical developments in genome engineering, enabling breakthrough discoveries in immunology, immuno-inflammation, rare diseases, neuroscience, and oncology. You will serve as a key scientific advisor and strategic thinker, shaping the direction of in vivo and preclinical research programs while championing the integration of emerging technologies — including AI and digital platforms — into transgenic science. This role is based in Cambridge, MA and is primarily office/lab-based with some scope for flexible remote working. Key Responsibilities Scientific Leadership & Innovation • Lead and advance state-of-the-art genome engineering techniques and mouse genetics applications for in vivo model development supporting discovery and developmental research • Apply personal expertise in transgenesis and CRISPR technology to devise and execute sophisticated experimental strategies for target validation, proof-of-concept, and efficacy studies • Identify, evaluate, and implement new technologies and innovations in transgenesis, CRISPR/Cas systems, and emerging genome engineering platforms • Serve as a strategic thinker and scientific advisor to research projects across therapeutic areas, providing expert guidance on in vivo and preclinical study design • Champion the integration of AI and digital technologies to enhance model design, data analysis, and predictive capabilities in transgenic research • Cover a broad scientific scope including immunology and immuno-inflammation, rare diseases, neuroscience, molecular and immune-oncology, and all areas of cell and molecular biology pertaining to immunology and immune-oncology Strategic Planning & Cross-Functional Leadership • Demonstrate strategic thinking and orientation in aligning transgenic capabilities with organizational research priorities and long-term scientific goals • Lead and coordinate transversal teams and projects across multiple therapeutic divisions, sites, and external partners • Collaborate closely with the Head of Transgenic Division, drug discovery program leaders, cluster heads, and department heads to provide strategic scientific advice • Drive budget planning, forecasting, and financial management to optimize resource allocation and operational efficiency Operational Excellence & Partnership Management • Establish and maintain comprehensive project management frameworks ensuring full-service delivery from model design through study-ready animal production • Build and manage strategic relationships with model providers, CROs, and academic partners for development and delivery of genetically modified models • Negotiate and oversee license agreements and partnership contracts for model acquisition and technology access • Implement quality standards and continuous improvement initiatives to maintain operational excellence People Leadership & Development • Supervise, mentor, and develop staff members to build a high-performing team at the forefront of transgenic science • Participate in talent management decisions including hiring, promotions, performance evaluations, and organizational development • Foster a culture of scientific excellence, innovation, collaboration, and continuous learning Minimum Education and Experience Required • Ph.D. in Molecular Biology, Genetics, Developmental Biology, or a related discipline • Extensive post-doctoral or industry experience in mouse molecular genetics and transgenic animal model development • Demonstrated track record of scientific leadership in an academic or pharmaceutical/biotech research environment • Minimum of 5 years of demonstrated, hands-on experience performing this role. Additional Qualifications Technical Expertise • Deep expertise in developing transgenic animal models, including engineering diverse genetic alleles using CRISPR/Cas9, Cas12, base editors, prime editors, and other advanced genome engineering systems • Comprehensive knowledge of both theoretical principles and practical methodologies required to lead a state-of-the-art transgenic facility • Strong foundation in molecular biology, mouse genetics, embryology, and reproductive technologies • Experience across multiple therapeutic areas (immunology, oncology, rare diseases, neuroscience preferred) Leadership & Strategic Capabilities • Proven strategic thinking and orientation with ability to align scientific capabilities with business objectives • Demonstrated success leading transversal teams and managing complex, multi-stakeholder projects across sites and functions • Established track record as a scientific thinker and advisor to in vivo and preclinical research programs • Experience identifying, evaluating, and implementing new technologies and innovations in a research setting • Familiarity with and application of AI and digital technologies in biological research, model design, and data analysis Professional Skills • Exceptional project management skills with ability to oversee multiple concurrent initiatives • Strong contract negotiation and vendor management capabilities • Excellent budget planning, financial management, and resource allocation skills • Outstanding interpersonal and communication skills (written and verbal) for effective collaboration across diverse, global stakeholders • Proven ability to work in matrix organizations and influence without direct authority Personal Attributes • Self-motivated with demonstrated ability to lead and thrive in collaborative team environments • Comfortable managing competing priorities and adapting to dynamic research needs • Commitment to scientific excellence, integrity, and ethical research practices • Passion for mentoring and developing scientific talent • Candidates must be willing to travel as part of this position. What We Offer • Opportunity to shape the future of transgenic technology at a global biopharmaceutical leader • Access to cutting-edge technologies and resources across a world-class R&D organization • Collaborative, innovative research environment spanning multiple therapeutic areas • Competitive compensation and comprehensive benefits package • Professional development and career growth opportunities • Flexible work arrangements supporting work-life balance Why Choose Us? Bring the miracles of science to life alongside a supportive, future-focused team. Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave. Sanofi US Services and its U.S. affiliates are Equal Opportunity employers committed to a culturally inclusive workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. #GD-SG  #LI-GZ #LI-Hybrid #vhd Pursue progress, discover extraordinary Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video and check out our Diversity Equity and Inclusion actions at sanofi.com! US and Puerto Rico Residents Only Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. North America Applicants Only The salary range for this position is: $178,500.00 - $257,833.33 All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through the LINK. We are an R&D driven, AI-powered biopharma company committed to improving people’s lives and creating compelling growth. Our team is guided by one purpose: we chase the miracles of science to improve people’s lives. We want to build a healthier, more resilient world, and turn the impossible into the possible by discovering, developing, and delivering medicines and vaccines for millions of people around the world. Discover more about us visiting or via our movie We are Sanofi Start a career that makes a difference. Reinvention is in our DNA. It’s what drove our evolution from a small French enterprise to one of the world’s leading biopharma companies. Whether it’s using AI to shorten drug-discovery times or building trust in healthcare, you could be helping our teams make life better for patients, partners, and communities. This is where you grow your career. We open the door for you to explore new opportunities, push your limits, and connect with people who are driven by a shared purpose: we chase the miracles of science to improve people’s lives.