Grad Co-op - Protein Design for Target Discovery

Amgen is seeking a graduate intern/Co‑op researcher to conduct cutting‑edge research in protein design for target discovery. The program will involve state‑of‑the‑art computational modeling and laboratory experiments to identify disease‑relevant targets and engineer binders. Responsibilities Identify and catalog genetic variants that result in gain or loss of post‑translational modifications on therapeutically relevant cell‑surface proteins. Apply computational and AI‑based approaches to model the structural impact of PTM gain/loss on protein epitopes and therapeutic target accessibility. Design and optimize binders against disease‑relevant epitopes exposed by loss of PTM. Apply laboratory binder discovery and characterization workflows to validate lead binders. Design and execute laboratory experiments to characterize binder specificity, target engagement, and functional activity. Basic Qualifications 18 years or older. Graduated with a bachelor’s degree from an accredited college or university. Currently enrolled in an MBA, Master’s, PharmD, or PhD program and have completed the first year of the program before the internship starts. Enrolled in an accredited college or university following the potential internship or co‑op assignment. Must not be employed at the time the internship starts. Student must be located in the United States for the duration of the co‑op. Preferred Qualifications Currently pursuing a PhD in Computational Biology, Bioengineering, Biochemistry, Computer Science, or a related field. Experience with programming in Python and/or R. Strong analytical, problem‑solving, and communication skills. Experience with protein engineering, structural biology, computational protein design, or antibody discovery. Familiarity with AI/ML approaches for protein modeling and binder design. Experience with molecular dynamics simulations or protein structure prediction tools. Experience conducting biochemical experiments in a research laboratory. Prior research experience in computational and/or experimental biological sciences. Benefits Base pay range in the U.S.: $30–$40 per hour. Build a professional network that endures throughout your time with Amgen. Participate in executive and social networking events and community volunteer projects. EEO Statement Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law. We will provide reasonable accommodation to individuals with disabilities. #J-18808-Ljbffr BioSpace