Associate Scientist, Analytical Development

Neurodegenerative diseases are one of the largest medical challenges of our time. Denali Therapeutics is a biotechnology company dedicated to developing breakthrough therapies for neurodegenerative diseases through our deep commitment to degeneration biology and principles of translational medicine. Denali is founded on the collaboration of leading scientists, industry experts, and investors who share the vision that scientific discovery energetically applied to translational medicine is the key to delivering effective therapies to patients. We invite you to consider an opportunity with Denali to help achieve our goal of delivering meaningful therapeutics to patients. This position is part of a broader Large Molecule CMC Analytical and Formulation team. This is an opportunity to collaborate on formulation, process and analytical development activities across a broad range of large molecules, that cross the blood-brain barrier, for treating challenging diseases. Key Accountabilities/Core Job Responsibilities: Assist in the development of chromatography, electrophoresis, spectroscopy and mass spectrometry-based analytical methods to be used for product release, stability, and characterization testing. Contribute to the design and execution of experiments for demonstrating method robustness and performance. Prioritize and perform timely testing that enables bioprocess and formulation development teams to meet project timelines. Critically evaluate analytical data to support method development decisions and product quality comparisons. Maintain accurate and timely experiment records in electronic laboratory notebook (ELN). Summarize and present data in a clear and meaningful way. Author and review analytical test methods and development reports. Qualifications/Skills: B.S. or M.S. in Analytical Chemistry, Biochemistry, Chemical Engineering, Pharmaceutical Sciences or related scientific discipline with 2+ years of CMC analytical development experience in biotech/pharma. Hands-on experience with various analytical methods for measuring the purity of biologics and residual process impurities (i.e. chromatography, capillary electrophoresis, spectroscopy, LC-MS, etc.). Experience with chromatography and mass spectrometry acquisition and data analysis software. Excellent laboratory, critical thinking, scientific problem-solving, and organizational skills. Familiarity with good documentation requirements and industry guidance. Knowledge of statistical approaches for data interpretation and analytical method development. Motivated, detail-oriented, naturally curious individual with a creative approach to scientific problem solving. Excellent spoken and written communication skills. Salary Range: $106,000.00 to $138,000.00 . Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Denali offers a competitive total rewards package, which includes a 401k, healthcare coverage, ESPP and a broad range of other benefits. Learn more at This compensation and benefits information is based on Denali’s good faith estimate as of the date of publication and may be modified in the future. Denali is committed to its core company value of unity by creating a diverse and inclusive environment. We are proud to be an equal opportunity employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity and/or expression, status as a veteran, basis of disability, or any other federal, state, or local protected class. “Life at Denali” is a living reflection of our values: trust, unity, grit and growth. These are not just words we share—they shape how we show up, collaborate and push boundaries together. From the lab to the community, across functions and milestones, our culture thrives on shared purpose and relentless pursuit.