Clinical Research Nurse

Job Title: Clinical Research Registered Nurse - Oncology
Job Description
This role offers an experienced oncology Registered Nurse the opportunity to lead and support cutting-edge clinical research within a prestigious academic cancer center. You will coordinate complex oncology and hematology clinical trials, including CAR-T and other sponsor-driven drug studies, while working closely with physicians, research staff, and patients. The position focuses on patient-centered research activities such as enrollment, informed consent, adverse event reporting, and data management, all aimed at advancing cancer prevention, diagnosis, and treatment.
Responsibilities

• Coordinate and conduct oncology and hematology clinical research studies in accordance with Good Clinical Practice (GCP), institutional policies, and regulatory requirements.
• Support and collaborate with principal investigators (PIs), nurse practitioners, project managers, clinical research nurses, clinical research coordinators, and research assistants on assigned trials, with a strong focus on CAR-T and other innovative therapeutic studies.
• Identify and pre-screen potential study participants by reviewing medical records and eligibility criteria, and communicate with the care team to confirm suitability for enrollment.
• Lead and document the informed consent process, ensuring patients and families clearly understand study objectives, procedures, potential risks, and benefits.
• Provide ongoing clinical assessment and nursing care for patients enrolled in clinical trials, with particular attention to oncology and hematology treatment protocols.
• Monitor, assess, and document adverse events and serious adverse events, and report them accurately using CTCAE 4.0 or similar standardized criteria and sponsor requirements.
• Manage study-related data, including accurate and timely data entry, query resolution, and maintenance of study source documents and case report forms.
• Support regulatory compliance by adhering to IRB and human research protection regulations, including preparation and maintenance of required regulatory documents as needed.
• Collaborate with physicians and multidisciplinary teams to ensure protocol adherence, appropriate scheduling of study visits, and coordination of study-related procedures and tests.
• Participate in patient recruitment strategies, including communication with clinical teams and potential participants to promote enrollment into ongoing clinical trials.
• Utilize MS Office and other clinical research systems to track study progress, maintain logs, and generate reports for internal and external stakeholders.
• Contribute to problem-solving and process improvement initiatives within the research team to enhance study efficiency, data quality, and patient experience.
• Communicate effectively in writing and verbally with investigators, sponsors, monitors, and internal departments regarding study status, issues, and outcomes.
• Work both independently and as part of a large, collaborative research team to meet study timelines and performance goals across multiple active trials.
• Support the broader research mission to reduce the burden of cancer by helping translate scientific discoveries into new models of cancer prevention and treatment.

Essential Skills

• Current Registered Nurse (RN) license in the Commonwealth of Pennsylvania.
• 5+ years of experience as a Registered Nurse.
• 2-3 years of clinical research experience, preferably in oncology or hematology.
• Oncology nursing experience, including comfort working with cancer patients and oncology care teams.
• Experience with cancer medications and monitoring for treatment-related toxicities.
• Proficiency in adverse event reporting, including use of CTCAE 4.0 or similar standardized criteria.
• Knowledge of Good Clinical Practice (GCP) and clinical research processes.
• Experience as a clinical research nurse, research coordinator, or study coordinator in a clinical trial setting.
• Demonstrated comfort and professionalism interacting with physicians and multidisciplinary clinical teams.
• Knowledge of IRB processes and human research protection regulations.
• Strong computer skills with the ability to independently and proficiently work in the Microsoft Office suite (e.g., Word, Excel, Outlook).
• Effective written and verbal communication skills, including the ability to document clearly and communicate complex information to patients and colleagues.
• Ability to multi-task, prioritize, and problem-solve in a fast-paced research and clinical environment.
• Proven ability to work both independently and collaboratively as part of a team.

Additional Skills & Qualifications

• Bachelor of Science in Nursing (BSN) preferred.
• Hematology experience preferred, particularly with hematologic malignancies and bone marrow transplantation.
• Experience working on CAR-T or other cellular therapy studies is highly valued.
• Background in patient recruitment, pre-screening, and enrollment for clinical trials.
• Experience with regulatory documentation and coordination for clinical studies.
• Familiarity with data management practices in clinical research, including maintaining source documents and case report forms.
• Exposure to high-profile, sponsor-driven oncology drug trials and innovative clinical trial designs.
• Interest in contributing to translational research that brings discoveries from the lab to the clinic.
• Commitment to the mission of reducing cancer incidence, mortality, and morbidity through research and innovation.

Work Environment
You will work within one of the largest and most active lymphoma and cancer research teams in a major academic cancer center. The environment is fast-paced and research-intensive, with nearly 200 active clinical trials and a strong focus on translational research that brings laboratory discoveries into clinical practice. The lymphoma team includes project managers, a nurse practitioner, multiple clinical research nurses, clinical research coordinators, and research assistants, and staff are aligned with specific principal investigators they support. A substantial portion of the work centers on CAR-T and other cutting-edge therapeutic studies, supported by state-of-the-art equipment and facilities. The Cancer Center maintains a vibrant, well-funded research base with significant external grant support, offering opportunities to work on high-profile studies sponsored by prominent organizations. The culture emphasizes teamwork, scientific excellence, and a shared mission to reduce the burden of cancer while training future cancer researchers and improving prevention, diagnosis, and treatment.
Job Type & Location
This is a Contract to Hire position based out of Philadelphia, PA.
Pay and Benefits
The pay range for this position is $40.00 - $45.00/hr.
Eligibility requirements apply to some benefits and may depend on your job classification and length of employment. Benefits are subject to change and may be subject to specific elections, plan, or program terms. If eligible, the benefits available for this temporary role may include the following:
• Medical, dental & vision
• Critical Illness, Accident, and Hospital
• 401(k) Retirement Plan - Pre-tax and Roth post-tax contributions available
• Life Insurance (Voluntary Life & AD&D for the employee and dependents)
• Short and long-term disability
• Health Spending Account (HSA)
• Transportation benefits
• Employee Assistance Program
• Time Off/Leave (PTO, Vacation or Sick Leave)
Workplace Type
This is a hybrid position in Philadelphia,PA.
Application Deadline
This position is anticipated to close on May 27, 2026.
About Actalent


Actalent is a global leader in engineering and sciences services and talent solutions. We help visionary companies advance their engineering and science initiatives through access to specialized experts who drive scale, innovation and speed to market. With a network of almost 30,000 consultants and more than 4,500 clients across the U.S., Canada, Asia and Europe, Actalent serves many of the Fortune 500.


The company is an equal opportunity employer and will consider all applications without regard to race, sex, age, color, religion, national origin, veteran status, disability, sexual orientation, gender identity, genetic information or any characteristic protected by law.


If you would like to request a reasonable accommodation, such as the modification or adjustment of the job application process or interviewing process due to a disability, please email View email address on click.appcast.io for other accommodation options.



San Francisco Fair Chance Ordinance: Pursuant to the San Francisco Fair Chance Ordinance, for all positions located in the city and county of San Francisco, we will consider for employment qualified applicants with arrest and conviction records.



Massachusetts Lie Detector: It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.



Use of Artificial Intelligence (AI): We may use Artificial Intelligence (AI) to support parts of our hiring process, including sourcing, screening, and evaluating candidates. AI helps assess applications and qualifications, but final decisions are made by our hiring team. By applying, you acknowledge and agree that your application may be reviewed using AI tools.