Technical Development Principal Scientist - Computational Biophysics

Are you passionate about Computational Biophysics of proteins and looking for a meaningful role? We seek a creative, highly motivated scientist with a background in computational biophysics to join the Pharmaceutical Development Department in US-Pharma Technology Development. The Scientist will focus on evaluating, developing and employing a variety of in silico methods and workflows to support the development of biologics. Our unique focus on physics-based simulations, specifically Molecular Dynamics, allows us to help develop and deliver better medicines by reducing problem spaces even in the absence of sizable datasets to learn from. Over the past several years, we have had great success establishing a highly scalable Molecular Dynamics platform, complete with dedicated supercomputing infrastructure. The ideal candidate will be passionate about and capable of developing cutting‑edge computational methods and physics‑based simulation techniques to broaden our mechanistic understanding of physico‑chemical stability of complex molecular formats and protein drug products. For this position, the chosen individual would independently design, execute and analyze in silico experiments and then inform and collaborate with other scientists and engineers to determine paths forward for drug development. Who You Are Requirements Ph.D. in Computational Bioengineering, Biophysics, Computational Chemistry, Physics, Computer Science, Mathematics, or equivalent experience. Extensive in silico expertise with at least one widely used molecular modeling and Molecular dynamics simulation package (e.g., AMBER, GROMACS, NAMD, Rosetta). Familiarity with MOE, Schrodinger, docking tools, homology modeling, quantum mechanics, and structural rendering tools. Familiarity with high‑performance scientific computing and proficiency in at least one modern programming language (e.g., Python, Bash scripting, C). Demonstrated ability to independently design, execute, and analyze in silico experiments. Effective verbal and written communication skills, with proven experience collaborating in multi‑disciplinary teams. Ability to contribute insightful critical analysis beyond one’s specific field of expertise within a scientifically diverse organization. Experience in biologics pharmaceutical development is a plus, but not required. Relocation benefits are available for this job posting. The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 - 224,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job‑related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Benefits Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company’s policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants. #J-18808-Ljbffr