Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Senior Director, Oncology Small Molecule

$194.1k - $305.6k

Merck

Merck's Discovery Oncology division seeks a Senior Director to lead small molecule therapeutic development at its Boston site. The role combines strategic pipeline oversight with scientific leadership, driving oncology programs from discovery through clinical development while managing a team of scientists.

Responsibilities

  • Develop and execute pipeline strategy for oncology small molecule therapeutics at Boston site
  • Provide strategic oversight for programs transitioning from discovery through late-stage clinical development
  • Drive key milestones including candidate selection, IND-enabling studies, and early clinical support
  • Lead business development evaluations and identify external assets aligned with strategic vision
  • Mentor program leads and foster high-performance collaborative culture within discovery oncology team

Requirements

  • Ph.D. in Biology, Oncology, Pharmacology, Biochemistry, or related STEM field with 10+ years post-degree industry experience
  • Deep expertise in cancer biology and ability to translate insights into drug development strategies
  • Proven track record advancing multiple small molecule candidates into clinical trials
  • Direct experience with late-stage program leadership, IND writing, and regulatory interactions
  • Demonstrated people management of senior and junior scientists with project leadership achievements
  • Strong collaborative and communication skills across multidisciplinary teams
Vacancy posted 20 days ago
Similar jobs that could be interesting for youBased on the Senior Director, Oncology Small Molecule in Boston, MA vacancy
  • $194.1k - $305.6k

     ...Job Description Discovery Oncology is seeking a visionary and strategic leader to shape...  ...generation of our Company's Oncology small molecule therapeutics. Come join an incredible...  ...- ~ Experience managing a group of senior and junior scientists with a track record... 
    Senior
    Full time
    For contractors
    Local area
    Relocation
    Visa sponsorship
    Flexible hours
    Shift work

    Merck & Co.

    Boston, MA
    1 day ago
  • Sanofi is seeking a leader for Analytical Sciences within the Synthetics CMC Development group at the Cambridge Crossing site. The role oversees analytical strategies for drug substance and finished dosage forms, driving innovation and digitalization across the team. The...
    Senior

    BioSpace

    Cambridge, MA
    2 days ago
  • $188k - $259k

    About This Role   We are seeking a highly motivated and creative Director of Chemistry to join our Small Molecule Chemical Development team. In this role, you will lead and mentor scientific and engineering teams as you guide project progression from early-phase through... 
    Suggested
    Full time
    Contract work
    Temporary work
    Local area

    Biogen Idec

    Somerville, MA
    3 days ago
  • $168k - $252k

     ...generation, and decision-making. Although the primary focus will be small-molecule drug discovery, the successful candidate will also help extend...  ...to influence scientists, engineers, data scientists, and senior leaders across a matrixed organization.Education and... 
    Senior
    Full time
    Summer work
    Remote work
    Flexible hours
    2 days per week
    3 days per week

    Vertex Pharmaceuticals

    Boston, MA
    4 days ago
  • Biogen, Inc. in Cambridge, MA, seeks a Director of Chemistry to lead the Small Molecule Chemical Development team, guiding projects from early-phase to clinical development and enabling scalable manufacturing of diverse drug candidates. You will mentor scientific and engineering... 
    Suggested

    Biogen, Inc.

    Cambridge, MA
    3 days ago
  • $126k - $181.5k

     ...with an ambitious and exciting mission: to unlock the future of small molecule drug discovery. FL129 is developing a revolutionary approach...  ...Summary: We are seeking a motivated and highly collaborative Senior Scientist to join FL129’s growing team of experimental and computational... 
    Senior
    Contract work

    Seres Therapeutics

    Cambridge, MA
    1 day ago
  • $168k - $252k

     ...Vertex Pharmaceuticals seeks a senior scientific leader to advance artificial intelligence and agentic systems in small-molecule drug discovery. This role bridges computational drug design, data science, and engineering to develop AI-enabled workflows that enhance molecular... 
    Senior

    Vertex Pharmaceuticals

    Boston, MA
    22 days ago
  • $136.8k - $167.2k

     ...to both technical and non-technical audiencesServe as the team process chemistry SME across the matrix for oligonucleotide and small molecule synthesis; mentor and train junior scientists; and collaborate with stakeholders that support other modalities.About You:Solid... 
    Senior
    Full time

    Intellia Therapeutics

    Somerville, MA
    1 day ago
  • $235k - $330k

     ...is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly...  ...are valued, seen, and heard.How you’ll make an impact:The Senior Director, Outcomes, Value & Access will serve as Kymera’s strategic... 
    Senior

    Kymera Therapeutics

    Watertown, MA
    4 days ago
  •  ...information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the Role: The Senior Director, Oncology Forecasting reports to the Vice President, Global Insights and Analytics and leads the global forecasting function for Takeda... 
    Senior
    Minimum wage
    Local area

    Takeda

    Boston, MA
    1 day ago
  • $237.9k - $356.9k

    Job DescriptionGeneral Summary:The Senior Director, Immunology will oversee multiple research programs and initiatives that support the...  ..., including cell and genetic therapies, biologics, small molecules, and nucleic acid-based medicines.Strong scientific judgment... 
    Senior
    Full time
    Summer work
    Flexible hours

    Vertex Pharmaceuticals

    Boston, MA
    22 hours ago
  • $188k - $259k

     ...Biogen seeks a Director of Chemistry to lead small molecule process development teams from early-stage through late-phase drug development in Cambridge, MA. The role involves designing and optimizing robust manufacturing processes, mentoring scientific and engineering... 

    Biogen

    Cambridge, MA
    a month ago
  • $176k - $294.3k

     ...science to create new therapeutic modalities beyond traditional small molecules. FL111 is backed by Flagship Pioneering, bringing the...  ...our passion for impact to join us!THE ROLEFL111 is seeking a Director/Senior Director, Computational Chemistry to spearhead the design... 
    Senior
    Flexible hours

    Seres Therapeutics

    Cambridge, MA
    4 days ago
  • $263k - $292k

     ...organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is...  ...SummaryPrime Medicine is seeking an experienced Senior Director, Biometrics to serve as the senior biostatistics leader for the... 
    Senior
    Full time
    Temporary work
    Interim role

    Prime Medicine

    Cambridge, MA
    22 hours ago
  • $212k - $333.19k

     ...designed to incubate the future AI-powered operating models for large molecule discovery and deliver candidates to the clinic at industry...  ...experience of DMPK requirements for diverse modalities (e.g., small molecules, biotherapeutics).Responsibilities include directing... 
    Senior
    Minimum wage
    Local area

    Takeda

    Boston, MA
    1 day ago
  • $195k - $330k

     ...is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective...  ...but not required with 10+ years of CMC experience; Sr. Director level requires commensurate additional experience and... 
    Senior

    Kymera Therapeutics

    Watertown, MA
    3 days ago
  • $212k - $333.19k

     ...all information I submit in my employment application is true to the best of my knowledge.Job DescriptionAbout the role:The Senior Director, Oncology Search & Evaluation will be responsible for advancing the oncology portfolio through the integration of external... 
    Senior
    Minimum wage
    Local area
    Remote work

    Takeda

    Cambridge, MA
    4 days ago
  •  ...Senior Director, Medical Affairs, Hematologic Malignancies About the Company Mission-driven global biopharma advancing cutting-edge oncology therapies for high unmet needs. Industry Biotechnology Type Privately Held About the Role The Company is... 
    Senior

    Confidential

    Boston, MA
    4 days ago
  • $171.2k - $256.8k

     ...targets in cancer.This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and...  ...Avenue, in the Fenway area of Boston, Massachusetts.SummaryThe Director, GCP & GLP QA, reporting to the Executive Director, Quality, is... 
    Senior
    Contract work

    Tango Therapeutics

    Boston, MA
    4 days ago
  • $161.4k - $201.84k

     ...advancing two late-stage, potential franchise molecules, obexelimab and orelabrutinib....  ..., highly selective CNS-penetrant, oral, small molecule Bruton’s Tyrosine Kinase (BTK)...  ...Innovation!Position Summary:The Associate Director of Analytical Development and Quality Control... 

    Zenas BioPharma

    Waltham, MA
    2 days ago
  •  ...Role Senior Director, Oncology Forecasting, leading Takeda Oncology's global portfolio forecasting across marketed products, launches, pipeline assets, and lifecycle opportunities. Responsibilities develop forecasting standards, oversee long-term portfolio... 
    Senior
    Full time

    Jobleads-US

    Boston, MA
    1 day ago
  • $261k - $319k

     ...OVERVIEW Disc Medicine is seeking an experienced, strategic Senior Director, Toxicology to join our team. Reporting directly to the...  ...conferences PREFERRED QUALIFICATIONS Experience with both large and small molecule drug development Experience in hematology and rare disease... 
    Senior
    Remote work
    Flexible hours

    Disc Medicine

    Watertown, MA
    4 days ago
  • $115k - $215k

     ...Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly...  ...’ll make an impact:We are seeking an experienced Manager or Senior Manager of Patient Recruitment and Retention to lead our initiatives... 
    Senior
    Local area

    Kymera Therapeutics

    Watertown, MA
    3 days ago
  • $145k - $240k

     ...first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in... 
    Senior
    Contract work

    Kymera Therapeutics

    Watertown, MA
    4 days ago
  • $120k - $200k

    The Opportunity:As the Senior Associate/Associate Director of Portfolio and Strategy Operations, you will help ensure flawless...  ..., with an initial focus on enhancing small molecule therapeutic discovery in targeted oncology. Our Dynamo platform integrates an array of... 
    Senior
    Flexible hours

    Relay Therapeutics

    Somerville, MA
    3 days ago
  • $269k - $291.67k

     ...read the opportunity below and apply. The Opportunity The Senior Director Toxicology will support the strategy, design, and execution...  ...and clinical development across multiple programs including small molecules, peptides, protein‑based biologics, anti‑sense... 
    Senior
    Local area
    Remote work

    Amylyx Pharmaceuticals

    Cambridge, MA
    4 days ago
  • $190k - $260k

     ...pediatric glioma. Position Summary Lindonlight is seeking a Senior Director, Toxicology to serve as the primary toxicology expert...  ...portfolio spanning multiple therapeutic modalities, including small molecules, biologics, antibody-drug conjugates, oligonucleotides, and... 
    Senior
    Full time
    Contract work
    Monday to Friday
    Weekend work
    Afternoon shift
    2 days per week
    3 days per week

    Lindonlight

    Cambridge, MA
    5 days ago
  • $145k - $240k

     ...first degrader into the clinic for immunological diseases, Kymera is focused on building an industry-leading pipeline of oral small molecule degraders to provide a new generation of convenient, highly effective therapies for patients with these conditions. Founded in... 
    Senior
    Contract work

    Kymera Therapeutics

    Watertown, MA
    22 hours ago
  • $279.41k - $338.58k

     ...development or market access objectives in a global organization. The Senior Director provides expertise and guidance in collaboration with cross-...  ...should be directed to Chat with Ripley. R1602808 Senior Director Oncology Biostatistics #J-18808-Ljbffr Bristol Myers Squibb
    Senior
    Hourly pay
    Full time
    Temporary work
    Part time
    For contractors
    Summer work
    Live in
    Work at office
    Local area
    Remote work
    Flexible hours
    Shift work

    Bristol Myers Squibb

    Cambridge, MA
    1 day ago
  • $204k - $346k

     ...spanning organic and inorganic chemistry, molecules and nanoparticles, discovery and process...  ...experimental chemistry strategy in conjunction with senior advisors and will work closely with Lila'...  ...principles across therapeutics and other small-molecule innovation areas. Experience... 
    Senior
    Full time
    Work at office
    Local area
    Flexible hours

    Lila Sciences

    Cambridge, MA
    2 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Senior Director, Oncology Small Molecule. Be the first to apply!