Principal Scientist, Peptide Formulation

Merck's Discovery Pharmaceutical Sciences group seeks a Principal Scientist to lead peptide formulation development, characterization, and early-stage developability assessment. The role bridges preclinical research with clinical candidate selection across multiple peptide modalities and delivery routes.

Responsibilities

• Characterize physicochemical properties and assess developability of peptide candidates
• Conduct early formulation screening and optimization across various administration routes
• Execute laboratory experiments with minimal supervision and generate analytical datasets
• Provide formulation recommendations to partner functions including medicinal chemistry and safety teams
• Mentor junior scientists and contribute to departmental scientific initiatives

Requirements

• PhD degree with minimum 6 years of industrial peptide formulation experience
• Expertise in physicochemical characterization of peptides including oligomer state and fibrillation risk
• Demonstrated problem-solving ability and innovation through publications, presentations, or patents
• Excellent verbal and written communication skills
• Strong leadership and interpersonal skills for cross-functional collaboration
• Experience with preclinical or clinical formulation development preferred
• Background in drug delivery technology helpful

Compensation: $176,200-$277,300 base