Senior Scientist II, Computational Chemistry

Revolution Medicines seeks a Senior Scientist II in Computational Chemistry to lead drug discovery programs using computational, cheminformatics, and data science approaches. The role involves designing and optimizing novel therapeutics targeting RAS-addicted cancers through advanced modeling and strategic collaboration with multidisciplinary teams.

Responsibilities

• Lead computational chemistry strategy on multidisciplinary discovery teams and drive compound design from hit finding through optimization
• Design and implement virtual screening workflows using structure-based and ligand-based computational methods
• Develop compound prioritization strategies and risk-mitigation approaches for medicinal chemistry partners
• Collaborate with Advanced Analytics to create, validate, and advocate AI/ML models for molecular design
• Devise strategies to enhance hit-finding capabilities for novel protein and protein-protein interaction targets

Requirements

• Ph.D. in computational chemistry or related field
• 5+ years computational chemistry experience in biotechnology or pharmaceutical industry
• Demonstrated track record of impactful drug discovery contributions
• Expert knowledge of docking, virtual screening, and protein-ligand analysis methods
• Experience integrating SAR, structural biology, biophysical, and ADME/PK data
• Proficiency with physics-based modeling and free energy calculation methods
• Experience implementing and evaluating AI/ML workflows for molecular design