Senior Medical Science Liaison (Northeast/U.S. Oncology)

Company Overview Tango Therapeutics is a biotechnology company dedicated to discovering novel drug targets and delivering the next generation of precision medicine for the treatment of cancer. Using an approach that starts and ends with patients, Tango leverages the genetic principle of synthetic lethality to discover and develop therapies that take aim at critical targets in cancer. This includes expanding the universe of precision oncology targets into novel areas such as tumor suppressor gene loss and their contribution to the ability of cancer cells to evade immune cell killing. The Tango labs and offices are located at 201 Brookline Avenue, in the Fenway area of Boston, Massachusetts. Summary The Senior MSL is a U.S. field-based role within Medical Affairs, reporting to the Executive Director, Medical Affairs. This role will be a core member of Tango’s growing field medical team during a critical phase of development. The Senior MSL will be responsible for high‑quality scientific exchange, trial execution support, medical education, and insight generation across priority solid tumor indications, with an initial focus on pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC), and our evolving pipeline programs. This role is ideal for an individual who wants to operate at the intersection of clinical development, external scientific engagement, and launch readiness in a late-emerging biotech environment, where individual impact is high and scientific accountability matters. Your role Primary Focus: Solid tumors (pancreatic cancer (PDAC), non-small cell lung cancer (NSCLC) Scientific Exchange & External Engagement * Build and sustain deep, credible relationships with priority investigators, KOLs, and emerging scientific leaders in PDAC and NSCLC * Conduct high-quality, fair-balanced scientific exchange in response to unsolicited requests, grounded in a strong understanding of Tango’s biology, clinical data, and development strategy * Serve as a trusted scientific partner on disease biology, treatment paradigms, and evolving standards of care, particularly in high-unmet-need settings such as PDAC Clinical Development & Trial Execution Support

• Support Tango-sponsored clinical trials, with emphasis on:
• Site identification and activation
• Enrollment support and investigator engagement
• Ongoing scientific dialogue to enhance trial conduct
• Act as a Medical Affairs bridge between investigators and internal Clinical

Development and Clinical Operations teams * Contribute field-based perspective to protocol feasibility, study design considerations, and operational execution Insight Generation & Strategic Contribution * Capture and synthesize high-quality, hypothesis-driven insights from the field related to:

• Trial design and execution
• Competitive landscape
• Future evidence needs
• Translate insights into actionable feedback that informs Medical Strategy,

Clinical Development, and future regulatory and commercialization readiness * Contribute to refinement of Tango’s core scientific narrative as programs mature and data evolve Advisory Boards, Congresses & Scientific Presence * Support planning and execution of advisory boards, investigator meetings, and other scientific forums * Represent Tango at major medical and scientific congresses relevant to PDAC, NSCLC, and precision oncology * Maintain up-to-date knowledge of relevant literature, competitive activity, and guideline evolution Cross-Functional Collaboration & Compliance * Collaborate closely with Medical Affairs leadership, Medical Content, Clinical Development, Regulatory, and other cross-functional partners

• Serve as a scientific resource to internal stakeholders
• Uphold the highest standards of compliance, scientific integrity, and ethical

engagement What You Bring Education & Experience * 8 years of relevant experience with a bachelor’s degree, 6 years with a master’s degree, or 3 years with an advanced scientific or medical degree (e.g., PharmD, PhD, MD) Candidates with advanced clinical degrees (e.g., NP, PA) and significant oncology Medical Science Liaison experience will also be considered.

• Experience in PDAC, GI malignancies, or NSCLC strongly preferred
• Prior experience supporting clinical-stage or pre-launch oncology assets

highly valued Skills & Attributes * Strong scientific acumen with the ability to engage deeply on complex biology and emerging clinical data

• Demonstrated strength in insight generation, synthesis, and communication
• Comfortable operating in a fast-moving, high-accountability biotech

environment

• Excellent collaboration skills across matrixed teams
• Strong understanding of U.S. clinical research and healthcare environments

Compliance & Technical Requirements * Working knowledge of FDA, OIG, ICH, GCP, PhRMA Code, and applicable compliance standards

• Commitment to compliant, ethical scientific exchange
• Proficiency in standard business and field tools (CRM, MS Office, virtual

engagement platforms) Work Environment * Field-based role in the Northeast (Boston/New York), with residence required within assigned territory * ~ 50% domestic travel expected, with significant time spent with external scientific partners Why Join Tango Medical Affairs? * Be part of a Medical Affairs team built for a transition from mid-stage to late-stage development * Contribute directly to trial success, data readiness, and future regulatory and commercialization pathways * Expand and establish Tango as a credible clinical scientific leader in precision oncology * Work in a lean, collaborative environment where your scientific judgment and execution matter We are an equal opportunity employer and value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status. #LI-Remote Salary range

$157,600—$236,400 USD