Post Doctoral Research Scientist-Research & Innovation ( Biological Sciences)
$90k - $96kColgate-Palmolive Company
No Relocation Assistance Offered
Job Number #176034 - Piscataway, New Jersey, United States
Role Summary:
This Post Doctoral Research Scientist role focuses exclusively on understanding oxidative stress pathways and sensory responses in human oral mucosa triggered by oral care products. Your research will focus on developing in vitro and ex vivo models to study reactive oxygen species (ROS) associated pathways on oral mucosal and neuron-like cells. You will establish key biomarkers on oxidative stress related cytotoxicity. You will lead early-stage research programs that guide cross-functional teams in formulating safer, next-generation oral care products.
Responsibilities:
Discovery & Mechanistic Research
Scientific Discovery: Execute in vitro and ex vivo studies to evaluate oxidative stress induction and neuronal activation in oral tissue models exposed to novel formulations.
Mechanistic Cellular Pathology: Investigate cellular signaling cascades linked to oxidative stress and neurogenic sensory responses .
Biomarker Identification: Utilize -omics platforms to identify salivary and biological markers specific to oxidative markers and cytotoxicity.
Protocol Design: Standardize testing protocols for screening active ingredients based on redox balance and neuronal reactivity.
Technical Reporting: Translate oxidative and neuro-response dataset findings into guidelines for product development teams.
Cross-Functional Innovation Strategy
Interdepartmental Partnership: Communicate mechanistic findings on oxidative stress and neuro-activation to Safety, Regulatory, and R&D leadership.
Legal & IP Strategy: Work with Legal/IP to secure patent protection for novel models or formulations mitigating oxidative and neurological stress.
Laboratory Excellence & Data Science
Lab Models: Establish high-throughput oxidative assay screening systems.
Protocol Development: Standardize testing methods for quantifying ROS generation and neuronal responses.
Advanced Analytics: Leverage bioinformatics tools to analyze gene expression changes in oxidative and neuro response pathways.
Required Qualifications:
PhD in Oral Biology, Toxicology Oral Immunology, or a related field
Research experience in one or more of the following areas :
Oral Mucosal Irritation Expertise: Deep understanding of irritation on oral soft tissues and mechanism of action of compounds inducing oral ulceration .
Oral Immunology Expertise: Understanding of oral immunology, specifically the mechanisms of allergic sensitization and the inflammatory cascades leading to mucosal ulceration.
Biomarker Validation: Experience in identifying, quantifying, and validating biological markers from biosamples such as saliva and blood.
Bio-informatics: Data analysis and developing computable prediction models.
Preferred Qualifications:
Toxicology and Immunology: Hands-on experience.
Risk Assessment & Safety Evaluation: Database knowledge and computational prediction
Regulatory Knowledge: Safety databases, status of common oral care ingredients.
Compensation and Benefits
Salary Range $90,000.00 - $96,000.00 USD
Our journey begins with our people—developing strong talent with diverse backgrounds and perspectives to best serve our consumers around the world and fostering an inclusive environment where everyone feels a true sense of belonging. We are dedicated to ensuring that each individual can be their authentic self, is treated with respect, and is empowered by leadership to contribute meaningfully to our business. Equal Opportunity Employer
Colgate is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, gender, gender identity, sexual orientation, national origin, ethnicity, age, disability, marital status, veteran status (United States positions), or any other characteristic protected by law. Reasonable accommodation during the application process is available for persons with disabilities. Please complete this request form should you require accommodation. For additional Colgate terms and conditions, please click here . #LI-On-site
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