Senior Site Activation Manager

Role Description

This is a high-visibility opportunity for outstanding Site Activation Managers ready to step into a more strategic, sponsor-facing role within an FSP model. You’ll lead global site activation efforts while helping shape processes in a fast-evolving environment.

What You’ll Own

• End-to-End SSU Leadership
  • Drive global site start-up strategy and execution from site identification through activation and lifecycle maintenance
  • Own SSU timelines, forecasts, and delivery against contracted milestones
  • Identify risks early (regulatory, enrollment, timelines) and implement mitigation plans
• Operational Oversight
  • Lead all start-up deliverables, including:
    • Site identification and feasibility
    • Regulatory submissions and lifecycle maintenance (amendments, HA/EC communications, licenses)
    • CTA and investigator budget negotiation/execution
    • Essential document collection and TMF readiness
  • Ensure delivery aligns with SOPs, sponsor expectations, and quality standards
• Sponsor & Cross-Functional Engagement
  • Act as a key interface with sponsor stakeholders, presenting strategy, risks, and status
  • Partner across Clinical Ops, PM, Contracts, Data Management, Medical Writing, and SSU Country teams
  • Collaborate within a team-first, highly accountable FSP environment
• Financial & Scope Accountability
  • Review SSU budgets vs. milestones and support profitability targets
  • Track and manage out-of-scope activities in partnership with PM/SSU leadership
• Regulatory Leadership
  • Oversee preparation of core submission documents and amendment dossiers
  • Conduct Regulatory Impact Assessments and communicate risks
  • Support development of SIS/ICF documents and country-specific submissions
• Process & Build Mindset
  • Contribute to process creation and refinement as the team scales
  • Operate effectively in a setting where execution and process development happen in parallel

Qualifications

• Minimum 3 years prior experience as a Site Activation Manager (SAM)
• Minimum of 2 years' experience in managing large scale, US-based Site Activation with high success
• Strong track record delivering SSU activities across Phase II–IV trials
• Solid understanding of ICH-GCP, regulatory pathways, and start-up processes
• Demonstrated ability to manage multiple studies and competing priorities
• Strong communication, stakeholder management, and problem-solving skills

Requirements

• Highly Preferred
  • FSP (Functional Service Provider) experience
  • Prior Global SAM responsibility (regional experience considered with strong performance, if US based sites)
  • Experience integrating Syneos and sponsor systems
  • Proven ability to operate in ambiguity and help build processes while delivering
  • Track record of high performance and readiness for increased scope/visibility

Benefits

• Company car or car allowance
• Health benefits to include Medical, Dental and Vision
• Company match 401k
• Eligibility to participate in Employee Stock Purchase Plan
• Eligibility to earn commissions/bonus based on company and individual performance
• Flexible paid time off (PTO) and sick time