Portfolio / Program Manager - Operational Readiness (New Facility Introduction)

Overview Site Name: USA - Pennsylvania - Marietta Posted Date: Jun 2 2026 Business Introduction We manufacture and supply reliable, high‑quality medicines and vaccines to meet patients’ needs and drive our performance. Our network of 37 manufacturing sites delivered 1.7 billion packs of medicines and 409 million vaccine doses in 2024, helping to improve the health of millions of people. Our supply chain is central to our operations, enabling us to bring innovations to patients quickly, efficiently and effectively. Technology is transforming how we manufacture, increasing the speed, quality and scale of product supply. We need the very best minds and capability to help us on our journey to make more complex products, harnessing smart manufacturing technologies including robotics, digital solutions and artificial intelligence. Position Summary GSK is building a state‑of‑the‑art manufacturing facility, an $800M+ investment in pharmaceutical innovation. The Portfolio & Program Manager – Operational Readiness leads end‑to‑end operational readiness planning and execution for a new facility introduction. The role integrates cross‑functional workstreams, drives schedule acceleration, ensures governance discipline, and delivers operational excellence from day one. It runs in parallel with construction/commissioning to ensure the site is ready to accept handover and achieve successful PPQ / facility approval readiness through robust SOPs, training, tech transfer alignment, incoming materials readiness, procurement execution, and risk controls. Responsibilities Integrated Operational Readiness Plan & Schedule Build, maintain, and govern the integrated operational readiness schedule across workstreams (SOPs, Tech Transfer, GPS, Incoming Materials, Procurement) aligned to the Integrated Master Schedule and critical path. Drive schedule convergence and acceleration by identifying dependencies, sequencing conflicts, resourcing gaps, and pull‑forward actions; run weekly look‑ahead planning and escalation for overdue/at‑risk deliverables. Establish readiness stage‑gates and define entry/exit criteria with stakeholders to confirm readiness at critical milestones. Cross‑Functional Workstream Coordination SOPs & Document Readiness Coordinate prioritization, drafting, field shakedown, review, and approval of SOPs to enable shopfloor readiness. Ensure clear document strategy and ownership and maintain a document tracker integrated into the master schedule. Oversee the tracking and management of closure for safety, HAZOP, and risk assessment open items, ensuring all actions are completed in a timely manner. Coordinate across teams to guarantee proper resolution and communication of outstanding safety and risk‑related tasks. Tech Transfer / Readiness Interface Ensure operational readiness deliverables and timing remain aligned to Tech Transfer plans, donor site inputs, and QC method transfer planning. Integrate key Tech Transfer and QC readiness milestones into site reporting and governance. Oversee change control processes to ensure they are fully aligned with regulatory requirements. Continuously evaluate and refine change management practices, promoting accountability and timely decision‑making. GPS and Lean Six Sigma / Operating System Deployment Drive operational excellence foundations: tier governance cadence, GEMBA/self‑inspection routines, and readiness operating model embedded from the start. Enable stable execution through standard work, performance management, and continuous improvement rituals. Incoming Materials & Supply Readiness Coordinate supplier transparency setup, material master data readiness, BOM redlines, and incoming materials strategy/list development. Ensure materials readiness is linked to eBR/MES needs, procurement lead times, and commissioning/start‑up sequencing. Procurement & Package Readiness Track procurement readiness for key packages and address blockers; coordinate mitigations where procurement timing threatens critical path. Partner with Engineering/Project teams to ensure procurement deliverables support FAT/SAT, start‑up, and operational readiness needs. Smart Manufacturing Deployment Ensure the integration of smart manufacturing technologies and digital solutions across operational readiness workstreams to enhance process visibility and automation. Collaborate with IT, engineering, and operations to deploy advanced manufacturing systems such as IoT sensors, real‑time analytics platforms, and digital twins. Risk, Issue, and Dependency Management Own the operational readiness risk & issue management rhythm: identification, assessment, mitigation planning, and escalation. Maintain and govern the project risk register; ensure mitigations have owners, due dates, and are integrated into the readiness schedule. Facilitate recurring risk reviews and ensure lessons learned feed back into schedule, training, and readiness deliverables. Dashboards, Metrics, and Tier Governance Build and maintain readiness dashboards (tier boards/scorecards) for Safety, Quality, Supply, and schedule conformance; drive consistent weekly reporting. Define and implement KPI reporting discipline for monthly leadership updates; ensure data integrity and clear action linkage. Track readiness KPIs such as Right‑First‑Time execution, conformance to schedule, and critical path adherence; drive countermeasures through tier governance. Handover Readiness & Operational Integration Ensure operations is embedded with the project team and prepared for handover through early training exposure and readiness deliverables tied to system lifecycle activities. Promote a strong ownership and learning culture; leverage best practices and lessons learned from sister sites or prior launches where applicable. Key Deliverables Integrated Operational Readiness Master Schedule (workstream‑aligned, dependency‑mapped, critical‑path aware). Workstream dashboards and Tier governance reporting pack (weekly and monthly). Operational readiness risk register stewardship with mitigation tracking and escalation. Readiness stage‑gates / criteria and readiness review facilitation. Leadership‑ready summaries: RAG status, critical path impacts, top risks, key decisions required. Key Interfaces / Stakeholders Project leadership and program management Engineering / CQV / Commissioning teams Quality (QA/QC) and compliance partners Supply Chain, Incoming Materials, and Procurement Tech Transfer and donor site counterparts Automation / Digital (e.g., MES/eBR), Master Data, and IT partners Operations SMEs, Area Owners, and Training/L&D Success Measures Conformance to schedule: late task percentage and adherence to weekly plan / tier commitments. Critical path milestone adherence: no overdue items impacting critical path. Right‑First‑Time execution across readiness execution activities (e.g., readiness reviews, transfers, start‑up preparations). Risk closure rate and timely mitigation execution; reduced number of unmitigated high risks. Quality and compliance readiness at key stage‑gates (audit/inspection readiness indicators as defined by the program). Qualifications BS/BA in Engineering, Life Sciences, Operations, Supply Chain, or related field (MS/MBA helpful for seniority). 4+ years of experience in project, portfolio, or program management. Preferred Qualifications Program/Project credential (PMP, PgMP, or equivalent). Change management certification (Prosci) preferred if organization design/training adoption is heavy. Demonstrated program/portfolio management experience (integrated schedules, dependencies, critical path, governance cadence). Experience leading cross‑functional readiness, launch, or operationalization programs in regulated manufacturing environments. Strong risk/issue management discipline (risk registers, mitigation ownership, escalation). Executive‑ready communication skills: concise dashboards, narrative updates, and decision framing. New facility introduction / expansion experience; operational readiness executed in parallel with construction/commissioning. Familiarity with tier‑based management systems and shopfloor GPS cadence. Lean / Six Sigma experience, especially if the role is expected to embed GPS/continuous improvement. Exposure to digital manufacturing foundations (e.g., MES/eBR readiness coordination). Additional Information If you require an accommodation or other assistance to apply for a job at GSK, please contact the appropriate Recruitment Staff by emailing us at View email address on click.appcast.io. GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law. For more information, please visit #J-18808-Ljbffr