Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Senior Staff Engineer/Scientist, Bioinformatics

$202k - $215k

San Diego Stealth Startup

Job Description

Job Description

Location: San Diego, CA

Job Type: Full-Time

Salary $202,000 - $215,000


Position Overview

The Senior Staff Engineer, Bioinformatics will develop, advance, and support large-scale analysis of multi-omic data, through application of existing and novel methods. They will be responsible for developing scalable pipelines for cloud and HPC environments. The ideal candidate combines strong expertise in data science and software development, along with the ability to work cross-functionally with wet-lab and commercial teams.

Key Responsibilities

  • Analyze large-scale multi-omic data to delineate technical artifacts from biological signals.
  • Design and implement novel computational methods to improve signal detection and reduce compute costs.
  • Develop and maintain robust analysis pipelines.
  • Build and optimize reproducible workflows in cloud and HPC environments with attention to cost and scalability.
  • Identify and resolve technical artifacts through cohort-level and assay-aware analysis.
  • Partner with wet-lab scientists to diagnose and address assay artifacts.
  • Communicate findings clearly and contribute to technical decision-making.

Qualifications

Education:

  • Ph.D. in computational biology, computer science, statistics, genomics, or related field

Required:

  • 6+ years of professional experience in bioinformatics or closely related roles.
  • Ability to distinguish biological signal from technical noise using a variety of statistical, machine learning and deep learning methodologies.
  • Proficiency in programming languages frequently used for both ad hoc and scalable production multi-omic analyses.
  • Experience developing reproducible workflows in cloud or HPC environments.

Preferred:

  • Experience optimizing compute costs at scale
  • Experience developing commercial products

Why Join Us

  • Work in a dynamic, collaborative environment where innovation and scientific rigor are deeply valued.
  • Join a seasoned and multidisciplinary team tackling high-impact problems at the intersection of science and engineering.
  • Competitive compensation and equity package, comprehensive benefits, and flexibility to support work-life integration.

We are an equal opportunity employer. We thrive on diversity and collaboration.

Vacancy posted a month ago
Similar jobs that could be interesting for youBased on the Senior Staff Engineer/Scientist, Bioinformatics in San Diego, CA vacancy
  • $141.6k - $212.4k

     ...possible.Illumina is seeking an experienced Senior Staff Scientist to join the Assay On-Market Support...  ....Work effectively with Scientists, Engineers, Bioinformaticians, Software, Quality...  ...Quality, Regulatory, Manufacturing, Bioinformatics, Software, Commercial, and Marketing.... 
    Senior
    Full time
    Local area

    Illumina

    San Diego, CA
    12 hours ago
  • $175k - $190k

     ...Position Overview We are seeking a Senior Staff Scientist to provide technical leadership for...  ..., Clinical, Lab Operations, Bioinformatics, Software, Quality, and Regulatory throughout...  ...and influence scientific, engineering, operational, quality, and regulatory... 
    Senior
    Full time

    San Diego Stealth Startup

    San Diego, CA
    a month ago
  • $118.2k - $177.2k

     ...experienced and highly motivated Staff Scientist to help advance molecular...  ...with teams across Quality, Bioinformatics, Biostatistics, Software...  ...to project teams and senior leadership.Author and review...  ...development documentation, engineering studies, verification and validation... 
    Suggested
    Full time
    Local area

    Illumina

    San Diego, CA
    2 days ago
  •  ...Position: Staff/Senior Staff GPU Engineer - Shader RTL & Microarchitecture Location: San Diego, CA (4 days onsite) Employment Type: Full-Time Overview In partnership with a top-5 semiconductor company's leadership in SoC design, their GPU IP team is committed... 
    Senior
    Full time

    PER International

    San Diego, CA
    3 days ago
  • $120 - $170 per hour

    Yoh has an exciting opportunity for a Senior Staff Engineer, Autonomy Behaviors to join our advanced technology client supporting the development and deployment of next-generation autonomous systems. This senior-level engineering role will focus on designing sophisticated... 
    Senior
    Contract work
    Immediate start

    Yoh, A Day & Zimmermann Company

    San Diego, CA
    2 days ago
  • $230k - $350k

     ...Description:The Discrete Planning Group is a part of the Autonomy Team for Hivemind Enterprise Product. The group is an agile set of engineers focused on researching and developing state-of-the-art algorithms that drive intelligent and confidence-inspiring flight behaviors... 
    Senior
    Full time
    Temporary work
    Part time
    Worldwide

    Shield AI

    San Diego, CA
    1 day ago
  • $140k - $155k

     ...Solutions specializes in Systems and Software Engineering for intelligence/defense systems. We are...  ...seeking a highly skilled an experienced Staff Engineer to lead the development,...  ...manufacturing environments. This role requires a senior-level engineering professional capable... 
    Senior
    Local area

    Epsilon Systems Solutions

    San Diego, CA
    12 hours ago
  • Job Description Job ID#: 561244 Job Category: Pro - Engineering Position Type: Direct Placement Duration: Direct Placement Details: Job Title: Senior Staff Digital Design EngineerLocation: San Diego or San Jose CAEmployment Type: Direct/Full-timeIndustry: SemiconductorCompensation... 
    Senior
    Worldwide

    Acara Solutions

    San Diego, CA
    4 days ago
  • $233k - $350k

    San Diego, CaliforniaHivemind Enterprise Division - Engineering /Full Time Employee /On-siteShield AI is a venture-backed defense-tech...  ...deployments, and fully air-gapped systems.We are looking for a Senior Staff Engineer to help define and build this platform. You will... 
    Senior
    Full time
    Temporary work
    Part time
    Local area
    Worldwide

    Shield AI

    San Diego, CA
    3 days ago
  • $233.76k - $350.64k

     ...different office locations, customer sites, and flight integration events).Required Qualifications:BS/MS in Computer Science, Electrical Engineering, Mechanical Engineering, Aerospace Engineering, and/or similar degree, or equivalent practical experienceTypically requires a... 
    Senior
    Full time
    Temporary work
    Part time
    Work experience placement
    Work at office
    Worldwide

    Shield AI

    San Diego, CA
    1 day ago
  • $180k - $269.99k

     .../ Washington, D.C.Hivemind Solutions Division - Applications Engineering /Full Time Employee /On-siteShield AI is a venture-backed defense...  ..., the Middle East, and Asia-Pacific. Shield AI is hiring a Senior Customer Sustainment Engineer to support Hivemind systems after... 
    Senior
    Full time
    Temporary work
    Part time
    Worldwide

    Shield AI

    San Diego, CA
    4 days ago
  • $155.6k - $233.4k

     ...the role for you. You will be part of a culture fueled by innovation, collaboration, and openness.To be successful as a Staff Bioinformatics Scientist, you will need a background in bioinformatics with a particular focus on algorithm development, biomarkers and oncology... 
    Full time
    Local area
    Remote work

    Illumina

    San Diego, CA
    4 days ago
  • $114k - $228k

     ...mothers, female executives, and scientists. Position Overview The Staff Research Scientist is a Design Control...  ...design review boards; apprise senior management on project status,...  ...(NGS), and related sciences. ~ Bioinformatics knowledge related to nucleic acid... 
    Work at office
    Worldwide
    Shift work
    Night shift

    Abbott

    San Diego, CA
    2 days ago
  •  ...Qualcomm Technologies, Inc. is seeking a Senior Staff Engineer to define the future of silicon Diagnostics, AI, and yield intelligence within the Yield Architecture and Engineering organization. This leadership role blends diagnostics expertise with systems thinking... 
    Senior

    Jobleads-US

    San Diego, CA
    2 days ago
  • $141.6k - $212.4k

     ...Illumina seeks an experienced Senior Staff Scientist to lead technical initiatives for on-market clinical assays and library preparation products...  ...and failure investigations Collaborate with scientists, engineers, quality, regulatory, manufacturing, and commercial teams... 
    Senior

    Illumina

    San Diego, CA
    12 days ago
  • $169.8k - $254.6k

     ...Company: Qualcomm Technologies, Inc. Job Area: Engineering Group, Engineering Group Software Engineering General Summary...  ...that redefine mobility. About the role You'll be the senior technical authority for the embedded Linux platform software powering... 
    Senior
    Work experience placement
    Work from home

    Qualcomm

    San Diego, CA
    3 days ago
  • $230k - $350k

    San Diego, CaliforniaHivemind Enterprise Division - Engineering /Full Time Employee /On-siteShield AI is a venture-backed defense-tech company with the mission of protecting service members and civilians with intelligent systems. Its products include Hivemind autonomy software... 
    Senior
    Full time
    Temporary work
    Part time
    Work experience placement
    Worldwide

    Shield AI

    San Diego, CA
    4 hours ago
  •  ...Senior Staff Engineer - Test Development & Characterization An industry-leading medical technology company based in San Diego county is hiring a Senior Staff Engineer to lead test development and characterization of new wearable health monitoring devices. This individual... 
    Senior
    Full time
    Relocation package

    Meet Life Sciences

    San Diego, CA
    1 day ago
  • $117k - $176k

     ...Job TypeFull-timeDescriptionGeoEngineers is seeking a Senior Environmental Engineer or Scientist for our San Diego, CA office. Responsibilities of this...  ...relationships; business development; and mentoring junior staff.Essential Duties and ResponsibilitiesPlay a key role... 
    Senior
    Temporary work
    Work at office
    Local area

    GeoEngineers

    San Diego, CA
    3 days ago
  • $185.79k - $241.53k

     ...responsible for technical aspects of the foundry interface with external SOS, Off the Shelf, and SOI foundry partners. Senior Staff Foundry Engineer will drive and lead projects related sustaining fab process. This position has responsibility for: Maintain and sustain... 
    Senior
    Work at office
    Local area

    Jobleads-US

    San Diego, CA
    5 days ago
  •  ...Job Title:  Principal/Senior Staff Physical Design Engineer Location:  San Diego, CA or San Jose, CA Employment Type:  Full-time/Direct Industry:  Semiconductor Compensation:  180k-225k Schedule:  day time About the Opportunity: As a Physical Design... 
    Senior
    Full time
    Worldwide

    Acara Solutions

    San Diego, CA
    4 days ago
  •  ...pSemi Corporation, a Murata company, seeks a Senior Staff Foundry Engineer to lead sustaining fab processes and partnerships with external foundries. You will guide design rules, reliability and yield guardbands, and drive end-to-end transfer programs. Join a global... 
    Senior

    Jobleads-US

    San Diego, CA
    5 days ago
  • $208.85k - $271.52k

     ...Senior Staff Engineer, RFIC Design and AI Platforms Location: San Diego, CA, US pSemi Corporation is a Murata company driving semiconductor integration. pSemi builds on Peregrine Semiconductor’s 30-year legacy of technology advancements and strong IP portfolio... 
    Senior
    Work at office
    Local area

    Jobleads-US

    San Diego, CA
    3 days ago
  • $164k - $246k

     ...Company: Qualcomm Technologies, Inc. Job Area: Engineering Group, Engineering Group ASICS Engineering General Summary...  ...strategic, technically exceptional, and organizationally aware Senior Staff Engineer to help define the future of silicon Diagnostics, AI... 
    Senior
    Work experience placement
    Local area
    Immediate start
    Work from home

    Jobleads-US

    San Diego, CA
    2 days ago
  •  ...highly motivated and scientifically rigorous individual as a Senior Scientist, Principal Scientist, or Director of Translational Research...  ..., Clinical Development/Clinical Operations, Data Sciences (Bioinformatics), and external collaborators/CROs. The ideal candidate has... 
    Senior
    Summer holiday
    Local area

    Neomorph

    San Diego, CA
    3 days ago
  • $212k - $318k

     ...integrating distributed real-time systems, you’ll find this role rewarding. Join a team that’s driving innovation through robust software engineering and practical integration work across simulation environments, third-party systems, and development workflows.What You'll Do:... 
    Senior
    Full time
    Temporary work
    Part time
    Work experience placement
    Worldwide

    Shield AI

    San Diego, CA
    4 days ago
  • $130k - $160k

     ...Senior / Staff Manufacturing Engineer | San Diego, CA (100% on-site) Summary A venture-backed medical device startup in clinical studies is looking for a hands-on Manufacturing Engineer to own its in-house pilot line as it scales toward larger trials and commercial... 
    Senior
    Full time
    Shift work

    BioTalent

    San Diego, CA
    12 hours ago
  • $170k - $310k

     ...enables developers to build, train, tune, evaluate, optimize, and deploy learning-based autonomy solutions. You will join the Systems Engineering, Integration, & Test (SEIT) team in the Hivemind Enterprise organization.This ecosystem combines developer tools, APIs, data... 
    Senior
    Full time
    Temporary work
    Part time
    Worldwide

    Shield AI

    San Diego, CA
    4 days ago
  • $114k - $228k

     ...work for diversity, working mothers, female executives, and scientists. Position Overview This position works out of our...  ...location in the Abbott Cancer Diagnostics division. The Staff Bioinformatics Scientist is largely self-driven, working in collaboration... 
    Full time
    Work at office
    Worldwide
    Shift work
    Night shift

    Abbott

    San Diego, CA
    8 days ago
  • $220.8k - $331.2k

     ...position is ideal for an individual who thrives on solving complex integration challenges that span hardware, software, and systems engineering. A successful candidate will be skilled at deploying autonomy solutions onto unmanned platforms, preparing systems for flight,... 
    Senior
    Full time
    Temporary work
    Part time
    Work experience placement
    Work at office
    Worldwide

    Shield AI

    San Diego, CA
    1 day ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Senior Staff Engineer/Scientist, Bioinformatics. Be the first to apply!