Sign up to access all features of our service.
  • Job search
  • Favorites
  • Create a CV
    New
  • Salaries
  • Subscriptions

Senior Data Scientist - R&D DDSAI - Preclinical Sciences & Translational Safety

Full-time

Johnson & Johnson

At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at jnj.com

As guided by Our Credo, Johnson & Johnson is responsible to our employees who work with us throughout the world. We provide an inclusive work environment where each person is considered as an individual. At Johnson & Johnson, we respect the diversity and dignity of our employees and recognize their merit.

Job Function:

Data Analytics & Computational Sciences

Job Sub Function:

Data Science

Job Category:

Scientific/Technology

All Job Posting Locations:

Beerse, Antwerp, Belgium, Cornellà de Llobregat, Barcelona, Spain, Madrid, Spain, Spring House, Pennsylvania, United States of America

Job Description:

The R&D Data Science organization is seeking a Senior Data Scientist to leverage advanced machine learning, robust data engineering techniques, and domain expertise to drive impactful decisions and generate actionable insights within the Pharmaceutical Sciences & Translational Safety (PSTS) organization. In this role, you will work closely with multidisciplinary teams—including toxicologists, PK/PD specialists, in vivo researchers, and safety professionals—to create AI-ready datasets, develop predictive models, and deliver analytical solutions that promote improved safety evaluations and facilitate translational research.

The successful candidate possesses hands-on experience in machine learning and data engineering, complemented by a solid understanding of toxicology, pharmacokinetics/pharmacodynamics (PK/PD), in vivo experimentation, and translational science. Additionally, this role requires strong communication and problem-solving skills, a passion for innovation, and the ability to adapt to evolving scientific challenges in pharmaceutical R&D.

Key Responsibilities

Machine Learning & Modeling

  • Develop and deploy ML/AI models to support safety signal detection, dose selection, PK/PD modeling, toxicology insights, and translational interpretation.
  • Implement representation‑learning, predictive modeling, and multivariate analytics for datasets spanning in vivo studies, in vitro assays, exposure‑response data, and pathology information.
  • Partner with scientific SMEs to design modeling strategies aligned with PSTS decision points.
  • Apply model governance, versioning, and validation standards consistent with R&D AI practices.

Data Engineering & Pipeline Development

  • Build and maintain scalable data pipelines that integrate PSTS‑relevant data sources (e.g., toxicology studies, PK/PD datasets, biomarker readouts, animal study repositories).
  • Transform raw experimental outputs into standardized, analysis‑ready, AI‑ready datasets using Python, R, and cloud‑native services.
  • Contribute to harmonized scientific data models in collaboration with data engineering and ontology teams.

Scientific Domain Integration

  • Work directly with toxicology, DMPK, and safety stakeholders to interpret scientific context and translate study designs into computational requirements.
  • Apply understanding of mechanism‑based toxicology, exposure‑response concepts, and in vivo study structures to guide data transformations and modeling strategies.
  • Enhance cross‑study comparability via standardized terminologies, metadata practices, and quality checks.
  • Collaborate with PSTS functional experts, R&D Data Science teams, and platform architects to ensure high-quality, scalable data solutions.

Qualifications

Required

  • Advanced degree (MS or PhD) in Data Science, Computational Biology, Toxicology, Pharmacology, Biomedical Engineering, Computer Science , or related field.
  • 2+ years of experience applying machine learning and/or data engineering to scientific or biomedical datasets.
  • Proficiency with Python and/or R , SQL, and modern data engineering tooling (cloud computing, workflow orchestration, version control).
  • Experience with ML model development, evaluation, and deployment pipelines.
  • Experience working with biological, toxicology, PK/PD, or in vivo datasets.

Preferred

  • Experience in safety sciences, ADME/DMPK, toxicogenomics, or biomarker analytics.
  • Familiarity with scientific data formats (e.g., assay outputs, histopathology data, PK time-course datasets).
  • Exposure to ontologies, semantic technologies, or knowledge graph integration for scientific domains.
  • Experience with cloud‑based data architectures (AWS S3, Snowflake, Redshift).
  • Understanding of regulatory data standards (e.g., SEND, CDISC).

Why This Role Is Unique

This is a rare opportunity to grow in one of the world’s most ambitious and fastest-growing R&D Data Science organizations, shaping how PSTS data powers next‑generation therapies in the largest biomedical company on the planet. Your work will directly accelerate Johnson & Johnson’s scientific discovery, fuel AI innovation, and impact patients globally.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, external applicants please contact us via , internal employees contact AskGS to be directed to your accommodation resource.

#JRDDS

#JNJDataScience

JNJIMRND-DS

Required Skills:

 

 

Preferred Skills:

Advanced Analytics, Business Intelligence (BI), Coaching, Collaboration, Critical Thinking, Data Analysis, Database Management, Data Privacy Standards, Data Reporting, Data Savvy, Data Science, Data Visualization, Econometric Models, Process Improvements, Technical Credibility, Technologically Savvy, Workflow Analysis

 

 

The anticipated base pay range for this position is :

Additional Description for Pay Transparency:

Subject to the terms of their respective plans, employees are eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)).

This position is eligible to participate in the Company’s long-term incentive program.

Subject to the terms of their respective policies and date of hire, employees are eligible for the following time off benefits:

Vacation –120 hours per calendar year

Sick time - 40 hours per calendar year; for employees who reside in the State of Colorado –48 hours per calendar year; for employees who reside in the State of Washington –56 hours per calendar year

Holiday pay, including Floating Holidays –13 days per calendar year

Work, Personal and Family Time - up to 40 hours per calendar year

Parental Leave – 480 hours within one year of the birth/adoption/foster care of a child

Bereavement Leave – 240 hours for an immediate family member: 40 hours for an extended family member per calendar year

Caregiver Leave – 80 hours in a 52-week rolling period10 days

Volunteer Leave – 32 hours per calendar year

Military Spouse Time-Off – 80 hours per calendar year

For additional general information on Company benefits, please go to: -
Vacancy posted 12 days ago
Similar jobs that could be interesting for youBased on the Senior Data Scientist - R&D DDSAI - Preclinical Sciences & Translational Safety in Spring House, PA vacancy
  •  ...Job Function: Data Analytics & Computational Sciences Job Sub...  ...SUMMARY The R&D Data Science organization...  ...is seeking a Senior Scientist, Data Science...  ...colleagues in DDSAI, the role...  ...colleagues to translate defined needs into...  ..., content safety, and governance... 
    Senior
    Full time
    Local area
    Immediate start

    Johnson & Johnson

    Spring House, PA
    5 days ago
  •  ...Job Function: Data Analytics & Computational Sciences Job Sub Function:...  ...Innovative Medicine is seeking a Senior Data Scientist dedicated to our Small...  ...silico discovery teams. Translate scientific workflows and...  ...essential part of our R&D engine Trusted... 
    Senior
    Full time
    Local area
    Immediate start

    Johnson & Johnson

    Spring House, PA
    12 days ago
  • $196k - $342.7k

     ...Job Function: Data Analytics & Computational Sciences Job Sub Function...  ...a Sr Director - R&D DDSAI - Biologics Discovery...  ...will be to help our scientists discover the best...  ...multidisciplinary capabilities and translate advances in Tech...  .... Serve as a senior strategic partner... 
    Senior
    Full time
    Local area
    Immediate start
    Worldwide

    Johnson & Johnson

    Spring House, PA
    27 days ago
  • $137k - $235.75k

     ...their merit. Job Function: Data Analytics & Computational Sciences Job Sub Function: Data...  ...and clinical supply chain. The R&D Data, Data Science & AI (DDSAI) organization is seeking a Senior Principal Scientist, Data Science to lead the development... 
    Senior
    Full time
    Temporary work
    Local area
    Immediate start

    Johnson & Johnson

    Spring House, PA
    12 days ago
  • Johnson & Johnson is seeking a Senior Principal Scientist Pharmacology to lead NAMs-driven...  ...across discovery and preclinical development. You will guide NAM...  ...multidisciplinary teams, and shape translational approaches within oncology R&D. The role emphasizes expert NAMs... 
    Senior

    Johnson & Johnson Co.

    Spring House, PA
    2 days ago
  •  ...Job Function: Data Analytics & Computational Sciences Job Sub Function:...  ...POSITION SUMMARY The R&D Data, Data Science & AI (DDSAI) organization is seeking a Senior Scientist, Data Science to serve...  ...Solutions Director. Translate complex scientific and... 
    Senior
    Full time
    Local area
    Immediate start

    Johnson & Johnson

    Spring House, PA
    12 days ago
  • Johnson & Johnson is seeking a Senior Principal Scientist in Pharmacology to drive 3Rs NAMs opportunities across discovery and preclinical portfolios at Spring House, PA. You will lead...  ..., DPDS, and stakeholders, and shape translational NAM programs. The role requires a Ph.... 
    Senior

    Johnson & Johnson Co.

    Spring House, PA
    4 days ago
  •  ...Description: Position Title Senior Principal Scientist Pharmacology 3Rs...  ...the discovery and preclinical portfolio,...  ...PSTS (Preclinical Safety and Translational Sciences), and SIS strategic...  ...partnership with data science colleagues...  ...) within oncology R&D Understanding of pharmaceutical... 
    Senior
    Local area

    6010-Biosense Webster Inc. Legal Entity

    Spring House, PA
    4 days ago
  • MSD in North Wales, PA seeks a senior CSRM process owner to oversee pharmacovigilance and risk management activities, develop SOPs, and...  ...to-end processes. The role involves advisory support on product safety, regulatory interactions, and continuous process improvement under... 
    Senior

    MSD

    North Wales, PA
    6 days ago
  • Johnson & Johnson is seeking a Senior Principal Scientist/Associate Director in Translational Research to lead biomarker strategies for prostate cancer programs. You...  ...in a matrixed environment, communicating complex data to diverse audiences, and guiding external... 
    Senior

    Johnson & Johnson Co.

    Spring House, PA
    3 days ago
  • $210.4k - $331.1k

     ...Overview: Highly advanced understanding of safety/risk management to allow for overall...  ...to the Executive Director of CSRM Safety Science Innovation, Process and Systems with input...  ...processes, with the ability to translate complex regulatory and procedural requirements... 
    Senior
    For contractors
    Work at office
    Local area

    1000 Merck Sharp & Dohme LLC

    North Wales, PA
    1 day ago
  • $145.2k - $242k

     ...Position Summary The Senior Data Scientist will create connected data and...  ...at the intersection of data science, semantic modelling, manufacturing...  ...for CMC Acceleration, translating scientific and manufacturing...  ...Manufacturing Technologies, MSAT, R&D, Quality, Regulatory, and... 
    Senior
    Local area

    GSK LLP

    King of Prussia, PA
    5 days ago
  •  ...Role Senior Principal Statistician within Johnson & Johnson's Discovery Oncology Statistics...  ...experiments, analyze high-dimensional data from translational and in vivo studies; Foster cross-...  ...in Statistics, Biostatistics, Data Science, or related field; Minimum 6 years'... 
    Senior
    Remote work

    Johnson & Johnson Innovative Medicine

    Spring House, PA
    3 days ago
  • $82.1k - $172.4k

    Job Title: Senior AI/ML Engineer Job Category: Science Time Type: Full time Minimum Clearance...  ...large, complex sets of data to support AI/ML...  ...preferably as Data Engineer/Scientist, Machine Learning Engineer...  ...purpose - to ensure the safety of our nation. An environment... 
    Senior
    Full time
    Contract work
    Work experience placement
    Flexible hours

    CACI International, Inc.

    King of Prussia, PA
    4 days ago
  • Johnson & Johnson’s Discovery Oncology Statistics team seeks a Senior Principal Statistician to provide strategic statistical...  .... You will design experiments, analyze high-dimensional translational and in vivo data, foster collaborations, and develop analytics tools while... 
    Senior

    Johnson & Johnson Innovative Medicine

    Spring House, PA
    4 days ago
  • Role: Lead statistical safety evaluation within the CSS group for Oncology Therapeutic Area...  ...and strategic oversight for safety data analyses throughout the product lifecycle...  ...knowledge of drug development stages from preclinical to post-marketing, experience with AI tools... 

    Merck

    North Wales, PA
    2 days ago
  • $137k - $235.75k

     ...Development Job Sub Function Regulatory Science Job Category Scientific/...  ...Johnson & Johnson Innovative Medicine R&D is recruiting for a Senior Principal Scientist, CMC Regulatory Affairs -...  ...evaluate emerging regulatory trends and translate insights into regulatory and... 
    Senior
    Local area
    Immediate start

    Johnson & Johnson Co.

    Horsham, PA
    2 days ago
  • $137k - $235.75k

     ...Development Job Sub Function Translational Discovery &...  ...whose insights fuel our science-based advancements....  ...a highly motivated Senior Principal Scientist/ Associate Director...  ...that biomarker data informs patient selection...  ...(TE), response, safety and resistance. Ensure... 
    Senior
    Temporary work
    Local area
    Immediate start

    6084-Janssen Research & Development, LLC Legal Entity

    Spring House, PA
    3 days ago
  •  ...6 Catalyx specializes in the science of operational processes. With...  ...carefully automates and services R&D, production, packaging, and...  ...efficiency, performance, and safety. To learn more about the company...  ..., visit Job Description The Senior Project Manager provides... 
    Senior
    Work at office

    Xyntek Inc.

    Horsham, PA
    3 days ago
  • Scorpion Therapeutics is seeking a Lead statistician to oversee safety analyses in Oncology programs as part of the CSS group, providing scientific expertise and strategic oversight for safety analyses throughout the product lifecycle. You will partner with cross‑functional... 

    Merck

    North Wales, PA
    2 days ago
  • $70 - $72 per hour

    Join Our Client as a Scientist - III (Senior) and Make an Impact in Neuroscience...  ..., and advancement of preclinical pain pharmacology studies...  ...Familiarity with electronic data capture, statistical software...  ...experience supporting translational pharmacology initiatives and... 
    Senior
    Weekly pay
    Temporary work
    Monday to Friday

    Johnson Service Group, Inc.

    Lansdale, PA
    3 days ago
  • Role Senior Manager, Strategy and Operations, Data, Data Science and AI (DDSAI), serving as a strategic partner to enable data-driven decision-making within Johnson & Johnson's R&D. Responsibilities lead portfolio governance, strategic planning, resource management, and... 
    Senior

    Johnson & Johnson Innovative Medicine

    Spring House, PA
    4 days ago
  • Johnson & Johnson Innovative Medicine is seeking a Senior Principal Scientist, CMC Regulatory Affairs - Combination Products. This hybrid role can be located in Raritan, NJ; Titusville, NJ; Spring House, PA; or Horsham, PA. You will lead complex regulatory strategies for... 
    Senior

    Johnson & Johnson Co.

    Spring House, PA
    4 days ago
  •  ...Power BI service administration, including user management, connection management, workspace management, gateway administration, and data sources. Deploying three new Gateway clusters (eight nodes) and knowledge of creating Primary nodes and Clustered Nodes. Building... 
    Senior

    TechDigital Group

    West Point, PA
    2 days ago
  • $129k - $203.1k

     ...multiplier that will allow Development Sciences and Clinical Supply to deliver better experiments...  ..., automation and utilization of data to enhance insights, efficiency, and quality...  ...-ready data foundations. Requirements Translation: Act as a critical bridge between... 
    For contractors
    Local area
    Shift work

    Merck

    West Point, PA
    6 days ago
  • CSL seeks a Senior Pharmacovigilance Scientist (f/m/d) for post-marketing products in King of Prussia, PA. This role leads safety reviews across the product lifecycle, performing end-to-end...  ...signal detection and analysis of safety data from diverse sources. The position... 
    Senior

    CSL

    King of Prussia, PA
    5 days ago
  • CSL is seeking a Senior Pharmacovigilance Scientist to join our Global Safety & Pharmacovigilance team. You will monitor, evaluate, and manage the safety profile...  ...regulatory reporting. Reporting to the Vaccine Safety Science Lead, you will lead safety reviews, perform end‑to... 
    Senior

    CSL

    King of Prussia, PA
    5 days ago
  • CSL Behring seeks a Senior Pharmacovigilance Scientist to join our Global Safety & Pharmacovigilance team, focusing on monitoring, evaluating, and managing the safety profile of our products across their lifecycle. You will work with cross-functional global teams to support... 
    Senior

    BioSpace

    King of Prussia, PA
    2 days ago
  • MSD in West Point, PA is seeking an Associate Principal Scientist for the DMPK group within the PDMB function. You will lead translational DMPK efforts, assess DDI risk with PBPK, and collaborate across disciplines to advance small molecules and biologics. The role requires... 
    Senior

    MSD

    West Point, PA
    4 days ago
  • Johnson Service Group, Inc. is seeking a Senior Scientist in Lansdale to lead in vivo pain...  ...pharmacology studies. You will design and execute preclinical pain research, using rodent models and...  ...methods to generate robust behavioral data for target validation. The role... 
    Senior

    Johnson Service Group, Inc.

    Lansdale, PA
    3 days ago

Do you want to receive more vacancies?

Subscribe and receive similar vacancies to Senior Data Scientist - R&D DDSAI - Preclinical Sciences & Translational Safety. Be the first to apply!