Postdoctoral Scholar - Barlow lab

A postdoctoral fellow position is available in the Barlow laboratory in the Department of Microbiology and Molecular Genetics. The focus of the Barlow laboratory is to elucidate the molecular and genetic factors governing the causes and consequences of genome instability in primary, immortalized and transformed cells. The primary research aim of the laboratory is to investigate how secondary structures forming in DNA induce replication stress and DNA damage in highly proliferative cell types such as lymphocytes, and to define the mechanisms maintaining genome integrity during DNA replication and cell division. The lab has emerging projects on how genome instability interacts with the innate immune response and neurodegeneration and established projects investigating the impact of genome instability on the adaptive immune system using mouse as a model organism. The laboratory uses a combination of genetics, molecular biology, and next-generation sequencing to investigate where and how DNA damage arises, define downstream consequences on cell division and metabolism, and identify novel determinants underlying disease initiation and progression. Responsibilities The successful candidate is a highly motivated individual with a strong background in molecular and cell biology or computational biology that will manage an independent research project. The candidate will develop new assays, collaborate on multidisciplinary research projects, train junior lab members, present data at scientific meetings, and help write manuscripts. #J-18808-Ljbffr University of California