Director - PKDM - Small Molecule Portfolio Strategy & Leadership
$209.66k - $283.65kAmgen Inc. (IR)
Director - PKDM - Small Molecule Portfolio Strategy & LeadershipSkip to main content#Director - PKDM - Small Molecule Portfolio Strategy & Leadership page is loaded## Director - PKDM - Small Molecule Portfolio Strategy & LeadershipApplyremote type: On Sitelocations: US - California - South San Francisco: US - California - Thousand Oakstime type: Full timeposted on: Posted Todayjob requisition id: R-247807## **Career Category**Scientific## ## **Job Description**## Join Amgen’s Mission of Serving PatientsAt Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission—to serve patients living with serious illnesses—drives all that we do.Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.**Director - PKDM - Small Molecule Portfolio Strategy & Leadership**## **What you will do**Let’s do this. Let’s change the world. In this vital role you will serve as a strategic PKDM-BA leader on cross-functional teams, driving the advancement of small molecule programs from candidate discovery through clinical development and regulatory submission. You will combine deep scientific expertise with strong project leadership skills to influence portfolio strategy, support critical development decisions, and maximize the potential of small molecule therapeutic candidates.Key Responsibilities:* Provide strategic PKDM-BA leadership for small molecule discovery and development programs, enabling informed decision-making and successful advancement of portfolio assets.* Drive the progression of cross-functional project teams through scientific innovation, risk assessment, and proactive problem solving.* Lead PKDM-BA contributions to regulatory submissions, including INDs, NDAs, and interactions with global health authorities.* Define and execute scientific strategies that support candidate selection, optimization, development, and registration of small molecule therapeutics.* Identify, evaluate, and implement emerging technologies and approaches that enhance understanding of drug disposition and improve development outcomes.* Partner closely with business development teams to assess external opportunities and support scientific due diligence activities.* Build strong collaborative relationships across therapeutic areas and partner functions to advance portfolio objectives.* Recruit, develop, mentor, and inspire scientific talent while fostering a culture of scientific excellence and innovation.* Contribute to organizational strategy and help shape the future direction of small molecule PKDM-BA capabilities at Amgen## **What we expect of you**We are all different, yet we all use our unique contributions to serve patients. The Director we seek is a seasoned leader with these qualifications.**Basic Qualifications:**Doctorate degree PhDORPharmDOR MD [and relevant post-doc where applicable] and 5 years of industry experience in Pharmaceutical Sciences, Pharmacokinetics, Drug Metabolism, Pharmacology, Chemistry, or a related disciplineORMaster’s degree and 8 years of industry experience in Pharmaceutical Sciences, Pharmacokinetics, Drug Metabolism, Pharmacology, Chemistry, or a related disciplineORBachelor’s degree and 10 years of industry experience in Pharmaceutical Sciences, Pharmacokinetics, Drug Metabolism, Pharmacology, Chemistry, or a related discipline.**Preferred Qualifications:*** A demonstrated track record of scientific and strategic leadership across multiple small molecule discovery and development programs.* Extensive experience supporting regulatory submissions for small molecule therapeutics, including INDs and NDAs.* Deep expertise in drug disposition, pharmacokinetics, and translational strategies that inform candidate progression and development decisions.* Proven success accelerating project advancement and influencing key portfolio decisions within a matrixed environment.* Prior experience in direct people management, including recruiting, coaching, developing, and leading high-performing scientific teams.* Experience working across multiple therapeutic areas and/or drug modalities.* Strong external scientific presence through publications, presentations, and engagement with the broader scientific community.* Excellent communication, collaboration, and leadership skills with the ability to influence stakeholders across functions and organizational levels.* Experience developing and mentoring scientists and building high-performing teams.## **What you can expect of us**As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well-being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.The expected annual salary range for this role in the U.S. (excluding Puerto Rico) is posted. Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.In addition to the base salary, Amgen offers a Total Rewards Plan, based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:* A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts* A discretionary annual bonus program, or for field sales representatives, a sales-based incentive plan* Stock-based long-term incentives* Award-winning time-off plans* Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.## Apply now and make a lasting impact with the Amgen team.## **careers.amgen.com**In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.## **Application deadline**Amgen does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.## SponsorshipSponsorship for this role is not guaranteed.As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.Amgen will consider for employment qualified applicants with criminal histories in a manner consistent with the San Francisco Fair Chance Ordinance.**Salary Range**209,656.75USD -283,653.25 USD #J-18808-Ljbffr Amgen Inc. (IR)
$232.6k - $287.4k
...rare possibilities The Director, CMC Quality Control - Small Molecules is responsible for providing... ...supporting hybrid portfolios in a virtual QC model.... ...technical and strategic leadership for small molecule QC,... ...ensuring phase‑appropriate QC strategies and data integrity....SuggestedOngoing contractFull timeContract workWork at officeLocal areaFlexible hours2 days per week3 days per week$200k - $240k
Director, Small Molecule Discovery Biology (Inflammation & Autoimmunity) Alumis... ...advancing our early portfolio of small molecule autoimmune... ...including conceptualizing project strategy, recognizing knowledge... ..., or overall project team leadership Knowledge of and hands on...SuggestedWork experience placement- ...experienced and highly motivated Small Molecule CMC Principal / Director to join a growing... ...Manufacturing and Controls (CMC) strategy for small molecule... ...to work with a diverse portfolio of development-stage and... ...technical, and regulatory leadership to clients while supporting...SuggestedFlexible hours
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$193k - $246k
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...Management Group is responsible for driving drug development molecule, strategy, and partnering teams to advance science and medicine for... ...program schedules to enable accurate program, financial and portfolio analyses and ensure accurate inputs are provided into business...Full timeLocal areaRelocation package$138k - $197k
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...highly collaborative Senior Director to provide scientific, operational, portfolio, and people leadership to support discovery... ...-for-purpose bioanalytical strategies,- enabling high-quality, timely... ...a portfolio of biologics, small molecules, conjugates, and novel modality...Full timeFor contractorsLocal areaRelocationVisa sponsorshipFlexible hoursShift work$205k - $258k
Position Summary Reporting to the Executive Director, Analytical Development, the Director... ..., validation, specification strategy, stability programs, and analytical control... .... This role requires deep expertise in small‑molecule analytical sciences, regulatory expectations...$230k - $255k
Director, Program and Portfolio Management Septerna is a biotechnology company based... ...of GPCR-targeted small molecule programs with potential for... ...to-end program management leadership, serving as the operational... ...align execution with company strategy. As the point of contact...Full timeContract workFor contractorsFor subcontractorWork at office$195k - $260k
...model allowsscience and small teams of experts to lead... ...You'll Do The Associate Director/Director, Commercial Strategy & Operations will be instrumental... ...to market. This pan-portfolio role will drive effective... ...value demonstration Strong leadership skills and ability to...Full timeWork at officeHome officeFlexible hours$163k - $200k
...orally available, superior small molecule medicines that overcome... ...Position Summary The Associate Director, Trial Master File at... ...the clinical trial portfolio. This role ensures that TMF... ...Associate Director provides leadership over TMF strategy, vendor oversight,...For contractors$207k - $250k
...Director, Medicinal Chemistry South San Francisco, California... ...experienced chemistry leadership to small molecule drug discovery programs in Kardigan's preclinical portfolio. This role involves providing... ...data, analyses, and strategies to project teams and in governance...$186k - $220k
...orally available, superior small molecule medicines that overcome current... ...Summary:The Associate Director of Clinical Operations plays... ...ResponsibilitiesClinical Study Leadership: Lead and coordinate activities... ...and timelines.Operational Strategy & Execution: Work with leadership...Contract workRemote work$140k - $180k
...manufactured reliably at scale.As the Senior/Staff Technical Program Manager for Manufacturing Strategy & Operations, you will serve as a strategic partner to the Director and leadership team. You will translate manufacturing goals into clear strategies, analytical decisions,...Local areaShift work- ...partner with senior leaders across CX, Security, ESTO, and People Success to shape hiring strategy and workforce planning. You will own recruiting operations for your portfolio, drive improvements, and foster a high-performance culture rooted in accountability and collaboration...
$194k - $250k
...difference, every day. Position Title: Director, GCP Inspection Readiness and Audits Strategy Department: Quality Reports To:... ...member of the Clinical Quality Leadership Team. Essential Duties and... ...with Kardigan’s stage and evolving portfolio. Partner closely with Clinical...$245k - $302k
...integrates expertise in small‑molecule drug discovery,... ..., and skilled Senior Director, Medical Writing to provide... ...and operational leadership across oncology programs... ...and registration strategies. You will partner closely... ...meet the portfolio needs. Requirements...Temporary workFor contractorsWork at office- Plasmidsaurus, a rapidly growing life sciences company, is seeking a VP People to shape its people strategy as it expands. This role will focus on leadership development, organizational design, and ensuring compliance across all operations. The ideal candidate will have...
$226.19k - $292.71k
...and help create possible, together.Job DescriptionThe Director, Market Access Strategy Cross-Portfolio will sit in Foster City, CA.Responsibilities:... ...teams, Market Access colleagues, and Market Access leadership.Operational Efficiency and Effectiveness:Maintain existing...Full timeFor contractorsLocal area- ...seeks a Head of Resourcing & Metrics within the Business Strategy & Operations function. You will lead enterprise-wide... ...planning, budgeting, and impact measurement for the PDD portfolio, guiding senior leadership with data-driven insights. You will coach a multi-geography...
- ...experienced Associate Director of Toxicology (... ...interpreting nonclinical safety strategies across discovery and... ...Strategy & Leadership Serve as the nonclinical... ...and timelines Support portfolio‑level decision‑making... ...Experience supporting small molecule drug development programs...
$235k - $285k
...and partners advance their AI strategies, and be part of a high-... ...global workplace and data center portfolios in the industry, with active... ...We're looking for a Senior Director, Real Estate & Portfolio... ...and Data Center Operations leadership to translate hiring forecasts...Temporary workWork at office
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