Senior Director, Toxicology

Revolution Medicines is a late-stage clinical oncology company developing novel targeted therapies for patients with RAS-addicted cancers. The company’s R&D pipeline comprises RAS(ON) inhibitors designed to suppress diverse oncogenic variants of RAS proteins. The company’s RAS(ON) inhibitors daraxonrasib (RMC-6236), a RAS(ON) multi-selective inhibitor; elironrasib (RMC-6291), a RAS(ON) G12C-selective inhibitor; zoldonrasib (RMC-9805), a RAS(ON) G12D-selective inhibitor; and RMC-5127, a RAS(ON) G12V-selective inhibitor, are currently in clinical development. As a new member of the Revolution Medicines team, you will join other outstanding professionals in a tireless commitment to patients with cancers harboring mutations in the RAS signaling pathway. The Opportunity We are seeking an experienced senior toxicologist, who combines scientific excellence with strategic leadership, for our Toxicology group within the Nonclinical Development and Clinical Pharmacology (NDCP) Department, to work in close collaboration with Research and Development colleagues on new and ongoing portfolio projects. Working within a highly collaborative, cross-functional organization, this role provides toxicology leadership from early research through all stages of clinical development, ensuring that safety assessments enable informed development decisions and global regulatory filings. The successful candidate will: Lead nonclinical safety strategy for multiple drug development programs spanning both small molecules and biologics. Serve as the toxicology representative on cross-functional Research and Development project teams, providing scientific guidance and influencing development strategy. Design, oversee, interpret, and communicate toxicology studies that support candidate selection, IND-enabling activities, and regulatory submissions. Author and review regulatory documents and ensure compliance with GLP, ICH, and global regulatory requirements. Provide expert interpretation of toxicology data within the context of the current scientific approaches/best practices, project objectives, and benefit-risk assessment. Lead nonclinical development sub-teams, mentor colleagues, and contribute to departmental strategy and process improvements. Collaborate with investigative toxicology team to drive mechanistic studies for target-, pathway- or off-target toxicities using in vitro and in vivo studies, including emerging new approach methodologies (NAMS) such as cell- and organoid-based assays and advanced imaging analyses. Drive innovation, solve complex scientific problems, and effectively manage multiple programs in a fast-paced environment. Required Skills, Experience and Education PhD in Toxicology or a related discipline with 10+ years, or M.S. degree with 15+ years, of relevant experience in the biopharmaceutical industry; DABT certification is desirable. Deep expertise in nonclinical safety assessment for small molecules and other modalities. Strong understanding of toxicology study design, GLPs, global regulatory requirements, with experience interacting with global regulatory authorities. Proven ability to lead cross-functional teams, influence strategy, and communicate effectively across scientific disciplines to resolve complex safety questions and support project decision-making. Strong scientific background and scientific aptitude with excellent critical thinking skills. Preferred Skills Expertise in integrating mechanistic, translational, and biomarker-based safety assessments into nonclinical development programs. Familiarity with impurity risk assessment, product quality, occupational and/or environmental toxicology, or in silico/computational toxicology. The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training. Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities. Base Pay Salary Range $244,000 - $305,000 USD Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status. Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCAA Notice and Privacy Policy. For additional information, please contact View email address on click.appcast.io. #J-18808-Ljbffr Revolution Medicines