Postdoctoral Fellow

Department: Pharmacological & Pharmaceutical Sciences Salary: $49,400 - $56,200 Description Possesses, understands, and applies a comprehensive knowledge in area of specialization. Develops understanding and skills to allow for completion of assignments that cross fields of specialization. Develops leadership and management skills. Receives/Reviews progress and evaluates results of experiments or projects under control or supervisory responsibility. Recommends changes in research, testing or experimental procedures. May be responsible for a single highly technical and complex piece of research equipment. May review and evaluate the effectiveness of personnel. May plan for and assign personnel to projects under control. Operates with latitude for unreviewed action. May receive general supervision conferring with higher levels only in unusual situations. Performs other job-related duties as required. About the Position The Egly Laboratory at the University of Houston College of Pharmacy is seeking to recruit a highly motivated postdoctoral fellow to join a growing research program. Current Research Areas Our laboratory focuses on ion channel function and molecular pharmacology, investigating how drugs, disease-associated mutations, and polygenic risk variants alter channel gating, trafficking, and permeation. We combine patch-clamp electrophysiology, high-throughput drug and genetic screening, affinity purification-mass spectrometry proteomics, and CRISPR gene editing to dissect these mechanisms. A particular strength of the lab is the use of human iPSC-derived models to assess polygenic risk — testing how combinations of common variants collectively shape channel function and disease susceptibility. A central goal of the lab is to translate these mechanistic insights into new therapeutic strategies for ion channel disorders. Areas of Interest Ion Channel Biology Molecular Pharmacology Cellular Electrophysiology iPSC Disease Modeling / Genetic Risk Drug Discovery Gene Therapy / CRISPR-based Approaches Related biomedical research fields Qualifications Applicants should possess: A Ph.D., M.D., or equivalent degree in pharmacology, cell biology, biophysics, or a related field Strong foundational skills in molecular and cellular biology Excellent communication and teamwork skills A strong work ethic and enthusiasm for scientific research Experience with one or more of the following is desirable, but not required Molecular Biology Experience with molecular cloning, plasmid design, and site-directed mutagenesis CRISPR / Gene Editing Experience with CRISPR-Cas9 gene editing, including guide RNA design and generation of knock-in/knockout cell lines Cell Culture (HEK / hiPSC) Experience with mammalian cell culture, including HEK293 cells and/or maintenance and differentiation of human iPSCs Electrophysiology Experience with patch-clamp electrophysiology (manual or automated platforms) or other electrophysiological techniques High-Throughput Screening Experience with high-throughput screening platforms (e.g., thallium flux assays, automated patch-clamp systems, fluorescence-based assays) Proteomics / Mass Spectrometry Experience with affinity purification-mass spectrometry (AP-MS) or other proteomic approaches Bioinformatics / Data Analysis Experience with bioinformatics tools and computational analysis of genomic, proteomic, or electrophysiological data Biochemistry Experience with standard biochemical techniques (e.g., Western blotting, co-immunoprecipitation, protein purification) Successful candidates should be highly self-motivated, intellectually curious, and committed to pursuing innovative and impactful research. MQ: Requires singular knowledge of a specialized advanced professional discipline or the highest level of general business knowledge, normally acquired through attainment of a directly job-related terminal degree or equivalent formal training in a recognized field of specialization that is directly related to the type of work being performed. No experience is required. All positions at the University of Houston-System are security sensitive and will require a criminal history check. The University of Houston System and its universities are Equal Opportunity Institutions. Everyone is encouraged to apply. #J-18808-Ljbffr