Senior Principal Research Scientist, Computational Chemistry

Job Summary IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small‑molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first‑in‑class targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody‑drug conjugates, or ADCs, for molecularly defined solid tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. Position Summary We are seeking an accomplished Senior Principal Research Scientist in Computational Chemistry with significant pharmaceutical industry experience to join our multidisciplinary small molecule drug discovery organization. This is a senior individual contributor role for a highly experienced computational chemist with a strong track record of advancing pharmaceutical discovery programs through hands‑on scientific impact. The successful candidate will support discovery project teams across target identification, hit discovery, lead optimization, and drug candidate selection. The role requires a high degree of independence, technical depth, and scientific judgment, and the candidate will apply modern computational chemistry approaches to directly inform medicinal chemistry design and project decision‑making. We are looking for a creative, detail‑oriented scientist with a passion for drug discovery and a collaborative mindset. The position is based in our South San Francisco headquarters and requires onsite presence four days per week. What you’ll do: Lead structure‑based drug design meetings with medicinal chemists and provide senior‑level, hands‑on drug design and computational chemistry support to small molecule drug discovery project teams Contribute to programs from target identification through lead optimization and drug candidate selection Apply structure‑, ligand‑, and fragment‑based modeling to guide medicinal chemistry design Use molecular dynamics, free energy methods, quantum chemistry, and cheminformatics to address complex design and prioritization questions Translate computational analyses into clear, actionable compound design recommendations Serve as a highly experienced computational contributor and scientific advisor within project teams Mentor and coach other scientists in structure‑based drug design through technical guidance and scientific discussion Evaluate new computational methods, tools, and workflows and apply them when they add clear value Maintain scientific rigor, reproducibility, and best practices in an industry drug discovery environment Requirements PhD in Computational Chemistry or a related discipline with 9+ years of pharmaceutical or biotechnology industry experience Strong understanding of small molecule drug discovery and medicinal chemistry principles Demonstrated expertise in structure‑, ligand‑, and fragment‑based drug discovery Expertise in free energy perturbation, molecular dynamics, quantum mechanics, cheminformatics, and ligand affinity estimation methods Proven ability to independently deliver computational work that influences medicinal chemistry decisions and project outcomes Ability to manage priorities across multiple discovery programs Excellent oral and written communication skills Experience applying machine learning or AI methods to molecular design, property prediction, or compound prioritization Experience with Schrödinger modeling software and others (e.g., MOE, OpenEye) Programming, scripting, statistics, and data analysis experience applied to drug discovery Experience working on challenging target classes, including protein–protein interactions and allosteric pockets Track record of contributing to discovery programs that advance high‑quality small molecule drug candidates All employees are expected to act with integrity and in full compliance with applicable laws, regulations, and IDEAYA policies, including IDEAYA’s Code of Conduct. Employees must demonstrate good judgement and ethical behavior in all business activities, maintain patient and product safety as a top priority, and report any suspected violations of law or Company policy through appropriate channels. Total Rewards Along with our inspiring mission and highly collaborative and inclusive environment, IDEAYA offers a competitive total rewards package that reflects our pay‑for‑performance philosophy where employees are eligible to be considered for merit‑based salary increases, company discretionary short‑term incentive plan participation, and company discretionary stock option awards (based on board approval). Our comprehensive benefits package includes, but is not limited to, medical/dental/vision coverage (100% company paid for employees and 90% company paid for dependents), 401(k), ESPP, and wellness programs. The expected salary range for the role of Senior Principal Research Scientist, Computational Chemistry is $196,000 – $242,000. The final salary offered to a successful candidate will depend on several factors that may include but are not limited to the office location where this open position is located, the final candidate’s experience within their profession, experience in the disease areas we are striving to make an impact in as a company, length of time within the industry, educational background, and performance during the interview process. The Company complies with all laws respecting equal employment opportunities and does not discriminate against applicants with regard to any protected characteristic as defined by federal, state, and local law. This position requires you to work onsite in the office at the Company’s facilities for training & meetings, with work‑from‑home flexibility, and the Company requires that all employees working in its facilities be fully vaccinated (except as required by applicable law). Therefore, this position requires you to be fully vaccinated from COVID‑19, subject to reasonable accommodations for medical or religious reasons, and/or as otherwise required by applicable law. IDEAYA is an equal opportunity employer. In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets. We are committed to providing reasonable accommodations to qualified individuals with disabilities. If you need assistance or an accommodation due to a disability, please get in touch with us at View email address on click.appcast.io. #J-18808-Ljbffr IDEAYA Biosciences