Principal Research Scientist, Analytical Chemistry

Job Summary IDEAYA is a precision medicine oncology company committed to the discovery, development, and commercialization of transformative therapies for cancer. Our approach integrates expertise in small‑molecule drug discovery, structural biology and bioinformatics with robust internal capabilities in identifying and validating translational biomarkers to develop tailored, potentially first‑in‑class, targeted therapies aligned to the genetic drivers of disease. We have built a deep pipeline of product candidates focused on synthetic lethality and antibody‑drug conjugates (ADCs) for molecularly defined solid tumor indications. Our mission is to bring forth the next wave of precision oncology therapies that are more selective, more effective, and deeply personalized with the goal of altering the course of disease and improving clinical outcomes for patients with cancer. When you are at IDEAYA, you will work with brilliant minds on precision medicine therapies to help cancer patients. We are passionate and committed about being on the forefront of oncology medicine. We are inquisitive, ask deep questions, data‑driven innovators and collaborate to move science forward. Location South San Francisco, CA. Position Summary We are seeking a talented and highly motivated individual with significant pharmaceutical industry experience to join our multidisciplinary team and help oversee all aspects of discovery analytical work. The successful candidate will work collaboratively with medicinal chemistry and related cross‑functional teams to successfully deliver drug discovery pipeline goals. This position is based in our South San Francisco headquarters and requires onsite presence four days per week. Reporting to: Vice President, Medicinal Chemistry. What you’ll do Oversee small molecule analytical chemistry efforts across the IDEAYA discovery portfolio Manage and execute compound purifications (including chiral SFC separations), structural elucidations, biophysical property determinations (such as solubility, logD, and pKa), and stability studies Manage junior analytical chemist(s) to achieve strong productivity with high quality and scientific rigor Ensure existing methods are technically sound, well developed and fit‑for‑purpose Troubleshoot methods and provide technical guidance across discovery programs Manage installation and maintenance of lab analytical equipment Perform vendor review and selection and provide oversight of all analytical work at external CROs Proactively communicate with and work closely with other functions to align analytical strategy and achieve goals Help hire high‑caliber analytical chemists as needed to build and grow a world‑class analytical department Stay aware of newly emerging techniques and technologies and bring new capabilities online as necessary Requirements Ph.D. in analytical chemistry or related discipline with a minimum of five years of drug discovery experience and demonstrated ability to work successfully within cross‑functional groups Strong subject matter expertise in small molecule purification (HPLC and SFC essential), physicochemical analysis, analytical method development/validation, and CRO management Additional experience with small molecule structural elucidation techniques is preferred Strong problem‑solving skills and ability to quickly adapt and shift focus as needed Strong interpersonal and communication skills and the ability to work within project teams Ability to multi‑task in a fast‑paced dynamic environment while demonstrating a calm and positive attitude and a superior work ethic Ability to supervise and mentor junior level associates and/or scientists, including direct reports or supporting team members All employees are expected to act with integrity and in full compliance with applicable laws, regulations, and IDEAYA policies, including IDEAYA’s Code of Conduct. Employees must demonstrate good judgement and ethical behavior in all business activities, maintain patient and product safety as a top priority, and report any suspected violations of law or company policy through appropriate channels. Total Rewards IDEAYA offers a competitive total rewards package that reflects our pay‑for‑performance philosophy. Employees are eligible for merit‑based salary increases, short‑term incentive plan participation, and stock option awards. The comprehensive benefits package includes medical, dental and vision coverage (100% company‑paid for employees and 90% company‑paid for dependents), 401(k), ESPP, and wellness programs. The expected salary range for the Principal Research Scientist, Analytical Chemistry is $167,000 – $206,000. The final salary offered will depend on factors such as location, experience, disease area expertise, and performance during the interview process. IDEAYA is an equal opportunity employer. In accordance with applicable law, IDEAYA does not discriminate in hiring or otherwise in employment based on race, color, religion, sex, national origin, age, marital or veteran status, disability, sexual orientation, or any other legally protected status. EOE/AA/Vets. #J-18808-Ljbffr IDEAYA Biosciences