Postdoctoral Research Associate - Pathology & Immunology

Position Summary A postdoctoral position (Ph.D. or M.D./Ph.D.) is available in the laboratory of Dr. Sadaf Amin at WashU Medicine in St. Louis to investigate innate immune pathways in neurodegenerative diseases and brain aging. The Amin Lab studies the role of neuro-immune interactions in the pathogenesis of neurodegeneration and age-related brain disorders. We are an enthusiastic and collaborative team seeking a highly motivated individual to join our new and growing research group. Projects include studying immune-RNA crosstalk in neurodegeneration to decipher the role of maladaptive innate immune pathways in neuronal stress and death, and examining how mito-nuclear retrograde signaling contributes to microglial dysfunction and senescence in Alzheimer’s disease and related dementias. Methods include iPSC-based systems, transgenic mouse models, single-cell sequencing, CRISPR-Cas9 screening, and interactome profiling. The work will contribute to advancing novel therapeutic targets for neurodegenerative disease. Job Description Primary Duties & Responsibilities Assists with grant preparation and reporting. Prepares and submits papers on research. Assists in the design of research experiments. Evaluates research findings and assists in reporting the results. Conscientious discharge of research responsibilities. Maintains conformity with ethical standards in research. Maintains compliance with good laboratory practice and adequate research records. Engages in open and timely discussion with mentor regarding possession or distribution of material, reagents, or records belonging to their laboratory and any proposed disclosure of findings. Collegial conduct towards co-trainees, staff members and members of the research group. Adheres to all applicable University policies, procedures and regulations. All data, research records and materials generated in University laboratories remain the property of the University. Working Conditions This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and provide standard care to research animals. Salary Range Base pay is commensurate with experience. Applicant Special Instructions Interested candidates should submit a cover letter, CV, and 3 letters of recommendation to Sadaf Amin at View email address on click.appcast.io. Required Qualifications Education: Ph.D., M.D., or equivalent terminal or doctoral degree. Certifications / Professional Licenses: No specific certification or license required. Work Experience: No specific work experience required. Skills: Not applicable. Driver’s License: A driver’s license is not required for this position. Preferred Qualifications A Ph.D. or M.D./Ph.D. in neuroscience, computational biology, cell and developmental biology, or a related discipline involving interrogation of cellular pathways using in vitro platforms and omics datasets. Prior experience with iPSC-based culture techniques and in vitro disease modeling (highly beneficial). Familiarity with transgenic mouse models and proper mouse handling techniques. Skills in at least one programming language (R or Python) are strongly preferred. Proficiency in conducting or analyzing single-nucleus RNA sequencing data and experience with Seurat or similar tools is encouraged. Accommodation If you are unable to use our online application system and would like an accommodation, please email View email address on click.appcast.io or call View phone number on click.appcast.io and leave a voicemail with the nature of your request. All qualified individuals must be able to perform the essential functions of the position satisfactorily, and reasonable accommodations will be made to enable employees with disabilities to perform the essential functions, absent undue hardship. Pre-Employment Screening All external candidates receiving an offer will be required to submit to pre-employment screening, including criminal background check, drug screening, employment and education verification, physical examination, vaccinations, and other applicable checks. Offers are contingent upon successful completion of required screening. Benefits Statement Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package. Benefits eligibility is subject to employment status, full-time equivalent workload, and weekly standard hours. Please visit to view a summary of benefits. EEO Statement Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. #J-18808-Ljbffr Washington University in St. Louis